Signal transduction through IL1R (WP4496)
Homo sapiens
Signal transduction through IL1R. Pathway based on Biocarta pathway (M12095). https://cgap.nci.nih.gov/Pathways/BioCarta/h_il1rPathway IL-1 signals primarily through the IL-1 receptor type 1 (IL-1R1). Through expression of cytokines such as TNF, TGF-beta and interferons, IL-1 holds a range of inflammatory activities that include induction of fever, expression of vascular adhesion molecules and roles in arthritis and septic shock. IL-1 binds to the respective IL-1 receptor however, it requires the IL-1 receptor accessory protein (IL-1RAP) to transduce a signal. Two kinases (IRAK-1 and IRAK-2) get activated through IL-1 binding to its receptor. Via these kinases a cascade gets activated which includes TRAF6, NF-kB activation and c-JUN activation. The IL-1 signaling cascade represents a highly conserved response to pathogens.
For a description of pathway objects, see the WikiPathways Legend.
Authors
Laurent Winckers , Friederike Ehrhart , and Eric WeitzActivity
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Cited In
- Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD) (2022).
- IL-1β signaling modulates T follicular helper and regulatory cells in human lymphoid tissues (2025).
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Organisms
Homo sapiensCommunities
ONTOXAnnotations
Pathway Ontology
immune response pathway signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| IFNA1 | GeneProduct | ncbigene:3439 | |
| IL6 | GeneProduct | ncbigene:3569 | |
| IRAK2 | GeneProduct | ncbigene:3656 | |
| IRAK3 | GeneProduct | ncbigene:11213 | |
| NFKB1 | GeneProduct | ncbigene:4790 | |
| NFKBIA | GeneProduct | ncbigene:4792 | |
| RELA | GeneProduct | ncbigene:5970 | |
| TGFB2 | GeneProduct | ncbigene:7042 | |
| TGFB3 | GeneProduct | ncbigene:7043 | |
| TNF | GeneProduct | ncbigene:7124 | |
| TOLLIP | GeneProduct | ncbigene:54472 | |
| MAP2K3 | GeneProduct | ncbigene:5606 | |
| TRAF6 | GeneProduct | ncbigene:7189 | |
| MAP3K1 | GeneProduct | ncbigene:4214 | |
| IKBKB | GeneProduct | ncbigene:3551 | |
| IRAK1 | GeneProduct | ncbigene:3654 | |
| MAPK8 | GeneProduct | ncbigene:5599 | |
| IFNB1 | GeneProduct | ncbigene:3456 | |
| MAP3K7 | GeneProduct | ncbigene:6885 | |
| MAP3K14 | GeneProduct | ncbigene:9020 | |
| MYD88 | GeneProduct | ncbigene:4615 | |
| TGFB1 | GeneProduct | ncbigene:7040 | |
| IL1RN | GeneProduct | ncbigene:3557 | |
| JUN | GeneProduct | ncbigene:3725 | |
| MAPK14 | GeneProduct | ncbigene:1432 | |
| CHUK | GeneProduct | ncbigene:1147 | |
| ECSIT | GeneProduct | ncbigene:51295 | |
| MAP2K6 | GeneProduct | ncbigene:5608 | |
| TAB1 | GeneProduct | ncbigene:10454 | |
| IL1RAP | GeneProduct | ncbigene:3556 | |
| IL1R1 | GeneProduct | ncbigene:3554 | |
| IL1A | GeneProduct | ncbigene:3552 | |
| IL1B | GeneProduct | ncbigene:3553 |
References
- Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants. O’Neill LA, Greene C. J Leukoc Biol. 1998 Jun;63(6):650–7. PubMed Europe PMC Scholia
- Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Cargnello M, Roux PP. Microbiol Mol Biol Rev. 2011 Mar;75(1):50–83. PubMed Europe PMC Scholia