Nucleotide-binding oligomerization domain (NOD) pathway (WP1433)

Homo sapiens

The NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importance of these molecules is underscored by the fact that mutations in the gene that encodes NOD2 occur in a subpopulation of patients with Crohn's disease, and NOD1 has also been shown to participate in host defence against infection with Helicobacter pylori. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Misbah , Kristina Hanspers , Michiel Adriaens , Thomas Kelder , Zahra Roudbari , Jonathan Mélius , Chris Evelo , Eric Weitz , and Egon Willighagen


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Homo sapiens



Pathway Ontology

NOD-like receptor signaling pathway


Label Type Compact URI Comment
CASP1 GeneProduct ensembl:ENSG00000137752
NLRP1 GeneProduct ensembl:ENSG00000091592
CENTB1 GeneProduct ensembl:ENSG00000072818
XIAP GeneProduct ensembl:ENSG00000101966
ERBB2IP GeneProduct ensembl:ENSG00000112851
NOD2 GeneProduct ensembl:ENSG00000167207
AAMP GeneProduct ensembl:ENSG00000127837
CARD9 GeneProduct ensembl:ENSG00000187796
NLRP10 GeneProduct ensembl:ENSG00000182261
RELA GeneProduct ensembl:ENSG00000173039
NLRP7 GeneProduct ensembl:ENSG00000167634
CARD6 GeneProduct ensembl:ENSG00000132357
CASP7 GeneProduct ensembl:ENSG00000165806
NLRP4 GeneProduct ensembl:ENSG00000160505
RIPK2 GeneProduct ensembl:ENSG00000104312
CASP8 GeneProduct ensembl:ENSG00000064012
IKBKG GeneProduct ensembl:ENSG00000269335
NLRP12 GeneProduct ensembl:ENSG00000142405
IL1B GeneProduct ensembl:ENSG00000125538
NLRP2 GeneProduct ensembl:ENSG00000022556
NLRP3 GeneProduct ensembl:ENSG00000162711
CASP9 GeneProduct ensembl:ENSG00000132906
SUGT1 GeneProduct ensembl:ENSG00000165416
IL18 GeneProduct ensembl:ENSG00000150782
CARD8 GeneProduct ensembl:ENSG00000105483
NDUFA13 GeneProduct ncbigene:51079
AIM2 GeneProduct ensembl:ENSG00000163568
DUOX2 GeneProduct ensembl:ENSG00000140279
NAIP GeneProduct ncbigene:4671
PRDM1 GeneProduct ensembl:ENSG00000057657
IKBKB GeneProduct ensembl:ENSG00000104365
NLRC4 GeneProduct ensembl:ENSG00000091106
NFKBIA GeneProduct ensembl:ENSG00000100906
PYCARD GeneProduct ensembl:ENSG00000103490
CASP5 GeneProduct ensembl:ENSG00000137757
COPS6 GeneProduct ensembl:ENSG00000168090
NOD1 GeneProduct ensembl:ENSG00000106100
HSP90AA2 GeneProduct ensembl:ENSG00000080824
RAC1 GeneProduct ensembl:ENSG00000136238
MEFV GeneProduct ensembl:ENSG00000103313
CHUK GeneProduct ensembl:ENSG00000213341


  1. Signalling pathways and molecular interactions of NOD1 and NOD2. Strober W, Murray PJ, Kitani A, Watanabe T. Nat Rev Immunol. 2006 Jan;6(1):9–20. PubMed Europe PMC Scholia