Nucleotide-binding oligomerization domain (NOD) pathway (WP1433)
The NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importance of these molecules is underscored by the fact that mutations in the gene that encodes NOD2 occur in a subpopulation of patients with Crohn's disease, and NOD1 has also been shown to participate in host defence against infection with Helicobacter pylori. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1433 CPTAC Assay Portal]
AuthorsMisbah , Kristina Hanspers , Michiel Adriaens , Thomas Kelder , Zahra Roudbari , Jonathan Mélius , Chris Evelo , Eric Weitz , and Egon Willighagen
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- SARS-CoV-2 induces “cytokine storm” hyperinflammatory responses in RA patients through pyroptosis (2022).
- Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma (2022).
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Pathway OntologyNOD-like receptor signaling pathway
- Signalling pathways and molecular interactions of NOD1 and NOD2. Strober W, Murray PJ, Kitani A, Watanabe T. Nat Rev Immunol. 2006 Jan;6(1):9–20. PubMed Europe PMC Scholia