Retinoblastoma gene in cancer (WP3206)

Bos taurus

Describes the role of retinoblastoma (RB) gene in cancer.

Authors

Martina Summer-Kutmon , Linda Rieswijk , Alex Pico , Friederike Ehrhart , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

disease pathway cancer pathway

Disease Ontology

cancer

Participants

Label Type Compact URI Comment
RB1 GeneProduct ensembl:ENSBTAG00000006640 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
E2F1 GeneProduct ensembl:ENSBTAG00000003971 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869
TFDP1 GeneProduct ensembl:ENSBTAG00000019645 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7027
ABL1 GeneProduct ensembl:ENSBTAG00000017976 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25
RBP1 GeneProduct ensembl:ENSBTAG00000020028 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5947
HDAC1 GeneProduct ensembl:ENSBTAG00000012698 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3065
SKP2 GeneProduct ensembl:ENSBTAG00000013562 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6502
CDKN1B GeneProduct ensembl:ENSBTAG00000018254 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027
CDK2 GeneProduct ensembl:ENSBTAG00000004021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017
CCNE1 GeneProduct ensembl:ENSBTAG00000004735 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:898
MYC GeneProduct ensembl:ENSBTAG00000008409 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
CCNA2 GeneProduct ensembl:ENSBTAG00000004943 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:890
MDM2 GeneProduct ensembl:ENSBTAG00000010422 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4193
TP53 GeneProduct ensembl:ENSBTAG00000001069 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
DNMT1 GeneProduct ensembl:ENSBTAG00000002736 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1786
HRMT1L1 GeneProduct ensembl:ENSBTAG00000005503 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3275
MCM7 GeneProduct ensembl:ENSBTAG00000030965 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4176
SUV39H1 GeneProduct ensembl:ENSBTAG00000004706 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6839
RAF1 GeneProduct ensembl:ENSBTAG00000045748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
MAPK13 GeneProduct ensembl:ENSBTAG00000010007 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5603
CDKN1A GeneProduct ensembl:ENSBTAG00000008353 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
CCNE2 GeneProduct ensembl:ENSBTAG00000004906 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9134
CDC25A GeneProduct ensembl:ENSBTAG00000009586 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:993
CCND3 GeneProduct ensembl:ENSBTAG00000010106 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896
CDK1 GeneProduct ensembl:ENSBTAG00000010109 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:983
PLK4 GeneProduct ensembl:ENSBTAG00000039552 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10733
NPAT GeneProduct ensembl:ENSBTAG00000010286 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4863
CCDC6 GeneProduct ensembl:ENSBTAG00000003189 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8030
CCNB1 GeneProduct ensembl:ENSBTAG00000014239 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:891
CCNB2 GeneProduct ensembl:ENSBTAG00000005269 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9133
MCM6 GeneProduct ensembl:ENSBTAG00000015172 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4175
RFC4 GeneProduct ensembl:ENSBTAG00000014727 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5984
TOP2A GeneProduct ensembl:ENSBTAG00000019262 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7153
CDC45L GeneProduct ensembl:ENSBTAG00000004286 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8318
MCM3 GeneProduct ensembl:ENSBTAG00000010721 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4172
RFC5 GeneProduct ensembl:ENSBTAG00000007137 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5985
RFC3 GeneProduct ensembl:ENSBTAG00000010787 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5983
MCM4 GeneProduct ensembl:ENSBTAG00000017021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4173
POLE GeneProduct ensembl:ENSBTAG00000000590 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5426
POLA1 GeneProduct ensembl:ENSBTAG00000008170 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5422
PRIM1 GeneProduct ensembl:ENSBTAG00000044000 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5557
ORC1 GeneProduct ensembl:ENSBTAG00000002719 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4998
CDT1 GeneProduct ensembl:ENSBTAG00000000638 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81620
SMARCA2 GeneProduct ensembl:ENSBTAG00000007494 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6595
CHEK1 GeneProduct ensembl:ENSBTAG00000017582 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1111
PCNA GeneProduct ensembl:ENSBTAG00000006065 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5111
RPA1 GeneProduct ensembl:ENSBTAG00000009711 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6117
MSH6 GeneProduct ensembl:ENSBTAG00000001424 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2956
PRKDC GeneProduct ensembl:ENSBTAG00000017019 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5591
BARD1 GeneProduct ensembl:ENSBTAG00000033690 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:580
TTK GeneProduct ensembl:ENSBTAG00000005456 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7272
SMC2 GeneProduct ensembl:ENSBTAG00000008772 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10592
KIF4A GeneProduct ensembl:ENSBTAG00000012861 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:24137
RRM1 GeneProduct ensembl:ENSBTAG00000013111 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6240
RRM2 GeneProduct ensembl:ENSBTAG00000008216 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6241
DHFR GeneProduct ensembl:ENSBTAG00000007681 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1719
DCK GeneProduct ensembl:ENSBTAG00000012397 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1633
HMGB2 GeneProduct ensembl:ENSBTAG00000015101 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3148
TYMS GeneProduct ensembl:ENSBTAG00000007003 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7298
STMN1 GeneProduct ensembl:ENSBTAG00000026505 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3925
RABIF GeneProduct ensembl:ENSBTAG00000013560 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5877
HLTF GeneProduct ensembl:ENSBTAG00000019704 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6596
ANLN GeneProduct ensembl:ENSBTAG00000009218 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54443
HMGB1 GeneProduct ensembl:ENSBTAG00000014862 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3146
CDC7L1 GeneProduct ensembl:ENSBTAG00000016307 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8317
WEE1 GeneProduct ensembl:ENSBTAG00000005278 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7465
POLE2 GeneProduct ensembl:ENSBTAG00000004931 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5427
CDC25B GeneProduct ensembl:ENSBTAG00000008436 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:994
SMC3 GeneProduct ensembl:ENSBTAG00000013905 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9126
SMC1A GeneProduct ensembl:ENSBTAG00000017761 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8243
MGC159566 GeneProduct ensembl:ENSBTAG00000015005 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2189
FAF1 GeneProduct ensembl:ENSBTAG00000014482 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11124
POLD3 GeneProduct ensembl:ENSBTAG00000016869 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10714
H2AFZ GeneProduct ensembl:ENSBTAG00000004428 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3015
SAP30 GeneProduct ensembl:ENSBTAG00000015578 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8819
SIN3A GeneProduct ensembl:ENSBTAG00000009985 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25942
RBBP7 GeneProduct ensembl:ENSBTAG00000002820 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5931
RBBP4 GeneProduct ensembl:ENSBTAG00000005904 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5928
CDK4 GeneProduct ensembl:ENSBTAG00000046091 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1019
CCND1 GeneProduct ensembl:ENSBTAG00000017514 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:595
E2F2 GeneProduct ensembl:ENSBTAG00000014400 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1870
E2F3 GeneProduct ensembl:ENSBTAG00000021045 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1871
TFDP2 GeneProduct ensembl:ENSBTAG00000006222 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7029
CDK6 GeneProduct ensembl:ENSBTAG00000044023 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1021
RPA1 Protein ensembl:ENSBTAG00000009711 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6117
RPA2 Protein ensembl:ENSBTAG00000006225 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6118
RPA3 Protein ensembl:ENSBTAG00000013168 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6119

References

  1. Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms. Welch PJ, Wang JY. Mol Cell Biol. 1995 Oct;15(10):5542–51. PubMed Europe PMC Scholia
  2. A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Welch PJ, Wang JY. Cell. 1993 Nov 19;75(4):779–90. PubMed Europe PMC Scholia
  3. Leukoencephalopathy: the frontier between what is reversible and what is persistent. Domínguez R, Famulari A, Vila J. Rev Neurol. 1997 Dec;25(148):2074. PubMed Europe PMC Scholia
  4. An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, et al. Mol Cell. 2004 Oct 8;16(1):47–58. PubMed Europe PMC Scholia
  5. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, et al. Mol Cell Biol. 2008 Sep;28(17):5369–80. PubMed Europe PMC Scholia
  6. MicroRNA 29b functions in acute myeloid leukemia. Garzon R, Heaphy CEA, Havelange V, Fabbri M, Volinia S, Tsao T, et al. Blood. 2009 Dec 17;114(26):5331–41. PubMed Europe PMC Scholia
  7. MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, et al. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21098–103. PubMed Europe PMC Scholia