Hypertrophy model (WP516)

Homo sapiens

Model of the effects of resistance exercise on gene regulation in human quadriceps muscle after an acute bout of isotonic exercise. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP516 CPTAC Assay Portal]


Alexander C. Zambon , David Robelin , Thomas Kelder , Kristina Hanspers , Alex Pico , Jonathan Mélius , Marianthi Kalafati , Andika Tan , Egon Willighagen , and Eric Weitz


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens




Pathway Ontology

hypertrophic cardiomyopathy pathway disease pathway

Cell Type Ontology

muscle cell cardiac muscle cell

Disease Ontology

heart disease


Label Type Compact URI Comment
WDR1 GeneProduct ncbigene:9948
EIF4EBP1 GeneProduct ncbigene:1978
IL1R1 GeneProduct ncbigene:3554
NR4A3 GeneProduct ncbigene:8013
IL1A GeneProduct ncbigene:3552
IFNG GeneProduct ncbigene:3458
EIF4E GeneProduct ncbigene:1977
VEGF GeneProduct ncbigene:7422
ATF3 GeneProduct ncbigene:467
TCF8 GeneProduct ncbigene:6935
JUND GeneProduct ncbigene:3727
GDF8 GeneProduct ncbigene:2660
ADAM10 GeneProduct ncbigene:102
CYR61 GeneProduct ncbigene:3491
ANKRD1 GeneProduct ncbigene:27063
DUSP14 GeneProduct ncbigene:11072
HBEGF GeneProduct ncbigene:1839
IFRD1 GeneProduct ncbigene:3475
MYOG GeneProduct ncbigene:4656
IL18 GeneProduct ncbigene:3606


  1. Time- and exercise-dependent gene regulation in human skeletal muscle. Zambon AC, McDearmon EL, Salomonis N, Vranizan KM, Johansen KL, Adey D, et al. Genome Biol. 2003;4(10):R61. PubMed Europe PMC Scholia