Statin pathway (WP1041)

Bos taurus

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Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism. Sources: [https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway PharmGKB] and [http://en.wikipedia.org/wiki/Statin Wikipedia]

Authors

Thomas Kelder , Alex Pico , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Cell Type Ontology

hepatocyte

Disease Ontology

cardiovascular system disease

Pathway Ontology

statin drug pathway

Participants

Label Type Compact URI Comment
Cholesterol Metabolite cas:57-88-5
Cholesterol Metabolite cas:57-88-5
Squalene Metabolite hmdb:HMDB0000256
Acyl-CoA Metabolite hmdb:HMDB0003419
Phospholipid Metabolite kegg.compound:C00865
DAG Metabolite kegg.compound:C00165
VLDL Metabolite chebi:39027
Cholesterol ester Metabolite kegg.compound:C02530
Statin Metabolite chebi:87631
Acetyl-CoA Metabolite hmdb:HMDB0001206
IDL Metabolite kegg.compound:C01834
Lipoproteins Metabolite chebi:6495
Cholesterol Metabolite cas:57-88-5
Mevalonate Metabolite chebi:25350
HDL Metabolite chebi:39025
Fatty acid Metabolite kegg.compound:C00162
Cholic Acid Metabolite cas:81-25-4
Cholesterol Metabolite cas:57-88-5
LDL Metabolite chebi:39026
Triglyceride Metabolite kegg.compound:C00422
ABCA1 GeneProduct ensembl:ENSBTAG00000020661 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19
ABCG8 GeneProduct ensembl:ENSBTAG00000016366 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64241
APOA1 GeneProduct ensembl:ENSBTAG00000002258 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:335
APOA4 GeneProduct ensembl:ENSBTAG00000019770 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:337
ABCA1 GeneProduct ensembl:ENSBTAG00000020661 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19
bta-mir-33a GeneProduct ensembl:ENSBTAG00000029975 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207932
APOC3 GeneProduct ensembl:ENSBTAG00000012398 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:345
APOA5 GeneProduct ensembl:ENSBTAG00000019764 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:116519
CYP7A1 GeneProduct ensembl:ENSBTAG00000005287 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1581
SCARB1 GeneProduct ensembl:ENSBTAG00000014269 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:949
PLTP GeneProduct ensembl:ENSBTAG00000000559 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5360
ABCG5 GeneProduct ensembl:ENSBTAG00000016365 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64240
APOA2 GeneProduct ensembl:ENSBTAG00000009212 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:336
LCAT GeneProduct ensembl:ENSBTAG00000018043 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3931
LDLR GeneProduct ensembl:ENSBTAG00000012314 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3949
APOB GeneProduct ensembl:ENSBTAG00000008505 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:338
DGAT1 GeneProduct ensembl:ENSBTAG00000026356 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8694
LPL GeneProduct ensembl:ENSBTAG00000012855 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4023
bta-mir-33b GeneProduct ensembl:ENSBTAG00000036437 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207839
SQLE GeneProduct ensembl:ENSBTAG00000005498 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6713
LIPC GeneProduct ensembl:ENSBTAG00000005479 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3990
SOAT1 GeneProduct ensembl:ENSBTAG00000004059 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6646
APOE GeneProduct ensembl:ENSBTAG00000010123 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:348
LRP1 GeneProduct ensembl:ENSBTAG00000010830 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4035
FDFT1 GeneProduct ensembl:ENSBTAG00000012432 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2222
HMGCR GeneProduct ensembl:ENSBTAG00000007840 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3156
PDIA2 Protein ensembl:ENSBTAG00000016575 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64714
ACSS1 Protein ensembl:ENSBTAG00000004281 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84532
MTTP Protein ensembl:ENSBTAG00000011944 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4547

References

  1. Microsomal triglyceride transfer protein. Wetterau JR, Lin MC, Jamil H. Biochim Biophys Acta. 1997 Apr 1;1345(2):136–50. PubMed Europe PMC Scholia
  2. Direct effects of statins on cells primarily involved in atherosclerosis. Chen H, Ikeda U, Shimpo M, Shimada K. Hypertens Res. 2000 Mar;23(2):187–92. PubMed Europe PMC Scholia