Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism.
Sources: [https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway PharmGKB] and [http://en.wikipedia.org/wiki/Statin Wikipedia]This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP430_r78268 WP430(78268)] with a 90.0% conversion rate.c3aHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64241HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:335HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:337HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19HomologyConvert: Multiple homologues found: En:ENSBTAG00000020558;En:ENSBTAG00000020558;HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207932HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:345HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:116519HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1581HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:949HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5360HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64240HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:336HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3931HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3949HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:338HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8694HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4023HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207839HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6713HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3990HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6646HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:348HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4035HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2222HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64714HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84532HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3156HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4547a6bhepatocyteCL:0000182Cell Ontologycardiovascular system diseaseDOID:1287Human Disease Ontologystatin drug pathwayPW:0000724Pathway Ontology10770267PubMedDirect effects of statins on cells primarily involved in atherosclerosis.Hypertens Res2000Chen HIkeda UShimpo MShimada K9106493PubMedMicrosomal triglyceride transfer protein.Biochim Biophys Acta1997Wetterau JRLin MCJamil H