NRP1-triggered signaling pathways in pancreatic cancer (WP5144)

Homo sapiens

This pathway model provides a holistic overview of the various signalling pathways which promote pancreatic cancer with the direct involvment of neuropilin 1, commonly known as NRP1. The multifaceted role of NRP1 in pancreatic ductal adenocarcinoma (PDAC) constitutes it as a promising therapeutic target for the fatal disease. The curation of the model was conducted by using the review done by Matkar et al. as a starting point and combining information gathered by several other studies investigating this particular phenomenon.


Konstantina Pandi , Martina Summer-Kutmon , and Eric Weitz


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Homo sapiens


CPTAC PancCanNet


Pathway Ontology

cancer pathway disease pathway signaling pathway

Disease Ontology

pancreatic adenocarcinoma


Label Type Compact URI Comment
Zinc Metabolite hmdb:HMDB0015532
COL1A2 GeneProduct ensembl:ENSG00000164692
NRP1 GeneProduct ensembl:ENSG00000099250
COL1A1 GeneProduct ensembl:ENSG00000108821
RELA GeneProduct uniprot:Q04206
AKT1 Protein uniprot:P31749
RAC1 Protein uniprot:P63000
SMAD2 Protein uniprot:Q15796
EGF Protein uniprot:P01133
NRP1 Protein uniprot:O14786
PLXNA2 Protein uniprot:O75051
MET Protein uniprot:P08581
SMAD4 Protein uniprot:Q13485
AKT3 Protein uniprot:Q9Y243
NRP1 Protein uniprot:O14786
SNAI1 Protein uniprot:O95863
MEK1 Protein uniprot:Q02750
CDH5 Protein uniprot:P33151
NFKB1 Protein uniprot:P19838
MMP9 Protein uniprot:P14780
SEMA3A Protein uniprot:Q14563
PI3K Protein eccode:
PLXNA4 Protein uniprot:Q9HCM2
cyclin E1 Protein uniprot:P24864
CDK2 Protein uniprot:P24941
ZIP4 Protein uniprot:Q6P5W5
CD31 Protein uniprot:P16284
ERK1 Protein uniprot:P27361
p27 Protein uniprot:P46527
CDH1 Protein uniprot:O14646
MMP2 Protein uniprot:P08253
SMAD3 Protein uniprot:P84022
HGF Protein uniprot:P14210
NRP1 Protein ensembl:ENSG00000099250
CDH2 Protein uniprot:O14647
GSK3 Protein uniprot:P49840
FAK Protein uniprot:Q05397
AKT2 Protein uniprot:P31751
PLXNA1 Protein uniprot:Q9UIW2
EGFR Protein uniprot:P00533
NRP1 Protein uniprot:O14786
ERK2 Protein uniprot:P28482
MEK2 Protein uniprot:P36507
SRC Protein uniprot:P12931
p130Cas Protein uniprot:P56945
TGFBR1 Protein uniprot:P36897
TGFB3 Protein uniprot:P10600
TGFB1 Protein uniprot:P01137
NRP1 Protein uniprot:O14786
TGFB2 Protein uniprot:P61812
TGFBR2 Protein uniprot:P37173
TGFBR3 Protein uniprot:Q03167
SNAI2 Protein uniprot:O43623
CTGF Protein uniprot:P29279
VEGFR1 Protein uniprot:P17948
VEGFA Protein uniprot:P15692
NRP1 Protein uniprot:O14786
VEGFR2 Protein uniprot:P35968
NFKB2 Protein uniprot:Q00653
RELB Protein uniprot:Q01201
REL Protein uniprot:Q04864
cyclin E2 Protein uniprot:O96020


  1. Association of axon guidance factor semaphorin 3A with poor outcome in pancreatic cancer. Müller MW, Giese NA, Swiercz JM, Ceyhan GO, Esposito I, Hinz U, et al. Int J Cancer. 2007 Dec 1;121(11):2421–33. PubMed Europe PMC Scholia
  2. Hepatocyte growth factor-mediated cell invasion in pancreatic cancer cells is dependent on neuropilin-1. Matsushita A, Götze T, Korc M. Cancer Res. 2007 Nov 1;67(21):10309–16. PubMed Europe PMC Scholia
  3. The role of neuropilins in cell signalling. Zachary IC, Frankel P, Evans IM, Pellet-Many C. Biochem Soc Trans. 2009 Dec;37(Pt 6):1171–8. PubMed Europe PMC Scholia
  4. The ZIP4 pathway in pancreatic cancer. Donahue T, Hines OJ. Cancer Biol Ther. 2010 Feb;9(3):243–5. PubMed Europe PMC Scholia
  5. VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells. Yoshida A, Shimizu A, Asano H, Kadonosono T, Kondoh SK, Geretti E, et al. Biol Open. 2015 Jul 24;4(9):1063–76. PubMed Europe PMC Scholia
  6. Neuropilin-1 is associated with clinicopathology of gastric cancer and contributes to cell proliferation and migration as multifunctional co-receptors. Li L, Jiang X, Zhang Q, Dong X, Gao Y, He Y, et al. J Exp Clin Cancer Res. 2016 Jan 22;35:16. PubMed Europe PMC Scholia
  7. Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma. Matkar PN, Singh KK, Rudenko D, Kim YJ, Kuliszewski MA, Prud’homme GJ, et al. Oncotarget. 2016 Oct 25;7(43):69489–506. PubMed Europe PMC Scholia
  8. Jack of many trades: Multifaceted role of neuropilins in pancreatic cancer. Matkar PN, Jong ED, Ariyagunarajah R, Prud’homme GJ, Singh KK, Leong-Poi H. Cancer Med. 2018 Oct;7(10):5036–46. PubMed Europe PMC Scholia
  9. The miR-141/neuropilin-1 axis is associated with the clinicopathology and contributes to the growth and metastasis of pancreatic cancer. Ma L, Zhai B, Zhu H, Li W, Jiang W, Lei L, et al. Cancer Cell Int. 2019 Sep 27;19:248. PubMed Europe PMC Scholia