Monoamine transport (WP3118)

Bos taurus

Authors

Martina Summer-Kutmon , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

monoamine transport pathway

Participants

Label Type Compact URI Comment
HEPES Metabolite cas:7365-45-9
reserpine Metabolite cas:50-55-5
noradrenaline Metabolite cas:51-41-2
anisomycin Metabolite chebi:338412
SB 203580 Metabolite cas:152121-47-6
dopamine Metabolite cas:51-61-6
epinephrine Metabolite cas:51-43-4
4-Aminobutanoic acid Metabolite cas:56-12-2
catecholamines Metabolite chebi:33567
serotonin Metabolite cas:50-67-9
Hemicholinium-3 Metabolite cas:312-45-8
Phorbol ester Metabolite cas:16561-29-8
citalopram Metabolite cas:59729-33-8
L-tryptophan Metabolite cas:73-22-3
TSC2 GeneProduct ensembl:ENSBTAG00000020617 tuberous sclerosis 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7249
SCAMP2 GeneProduct ensembl:ENSBTAG00000005844 secretory carrier membrane protein 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10066
RBL2 GeneProduct ensembl:ENSBTAG00000016243 retinoblastoma-like 2 (p130)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5934
AMPH GeneProduct ensembl:ENSBTAG00000031967 amphiphysin
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:273
STX1A GeneProduct ensembl:ENSBTAG00000017075 syntaxin 1A (brain)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6804
SYN1 GeneProduct ensembl:ENSBTAG00000005042 synapsin I
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6853
PVRL2 GeneProduct ensembl:ENSBTAG00000015318 poliovirus receptor-related 2 (herpesvirus entry mediator B)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5819
TNF GeneProduct ensembl:ENSBTAG00000025471 tumor necrosis factor
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
SLC5A7 GeneProduct ensembl:ENSBTAG00000004352 solute carrier family 5 (choline transporter), member 7
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:60482
FBXO32 GeneProduct ensembl:ENSBTAG00000016194 F-box protein 32
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:114907
SLC6A2 GeneProduct ensembl:ENSBTAG00000003353 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6530
INTB3 GeneProduct ensembl:ENSBTAG00000009987 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3690
CDC25C GeneProduct ensembl:ENSBTAG00000005293 cell division cycle 25 homolog C (S. pombe)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:995
NOS1 GeneProduct ensembl:ENSBTAG00000002023 nitric oxide synthase 1 (neuronal)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4842
ACHE GeneProduct ensembl:ENSBTAG00000001139 acetylcholinesterase (Yt blood group)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:43
DBH GeneProduct ensembl:ENSBTAG00000004508 dopamine beta-hydroxylase (dopamine beta-monooxygenase)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1621
TDO2 GeneProduct ensembl:ENSBTAG00000011062 tryptophan 2,3-dioxygenase
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6999
TNFRSF11B GeneProduct ensembl:ENSBTAG00000007423 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4982
AGT GeneProduct ensembl:ENSBTAG00000012393 angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:183
SLC6A3 GeneProduct ensembl:ENSBTAG00000015843 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6531
TPH2 GeneProduct ensembl:ENSBTAG00000020792 tryptophan hydroxylase 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:121278
HRH3 GeneProduct ensembl:ENSBTAG00000031625 histamine receptor H3
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11255
MAPK14 GeneProduct ensembl:ENSBTAG00000020783 mitogen activated protein kinase 14
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
TGFB1I1 GeneProduct ensembl:ENSBTAG00000002391 transforming growth factor beta 1 induced transcript 1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7041
SLC6A1 GeneProduct ensembl:ENSBTAG00000005857 solute carrier family 6 (neurotransmitter transporter, GABA), member 1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6529
IL1R1 GeneProduct ensembl:ENSBTAG00000005273 interleukin 1 receptor, type I
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3554
UNC13B GeneProduct ensembl:ENSBTAG00000011397 unc-13 homolog B (C. elegans)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10497
ADORA2A GeneProduct ensembl:ENSBTAG00000016944 adenosine A2a receptor
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:135
TH GeneProduct ensembl:ENSBTAG00000026768 tyrosine hydroxylase
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7054
PPP2CB GeneProduct ensembl:ENSBTAG00000009245 protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5516
IL1B GeneProduct ensembl:ENSBTAG00000001321 interleukin 1 beta
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
SLC6A4 GeneProduct ensembl:ENSBTAG00000019349 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6532

References

  1. Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders. Hahn MK, Blakely RD. Pharmacogenomics J. 2002;2(4):217–35. PubMed Europe PMC Scholia
  2. Developing novel treatments for mood disorders: accelerating discovery. Tamminga CA, Nemeroff CB, Blakely RD, Brady L, Carter CS, Davis KL, et al. Biol Psychiatry. 2002 Sep 15;52(6):589–609. PubMed Europe PMC Scholia
  3. A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity. Sung U, Apparsundaram S, Galli A, Kahlig KM, Savchenko V, Schroeter S, et al. J Neurosci. 2003 Mar 1;23(5):1697–709. PubMed Europe PMC Scholia
  4. A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters. Hahn MK, Robertson D, Blakely RD. J Neurosci. 2003 Jun 1;23(11):4470–8. PubMed Europe PMC Scholia
  5. Ultrastructural localization of the norepinephrine transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to probable dopamine terminals. Miner LH, Schroeter S, Blakely RD, Sesack SR. J Comp Neurol. 2003 Nov 24;466(4):478–94. PubMed Europe PMC Scholia
  6. Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice. Volpicelli-Daley LA, Hrabovska A, Duysen EG, Ferguson SM, Blakely RD, Lockridge O, et al. Mol Pharmacol. 2003 Dec;64(6):1309–16. PubMed Europe PMC Scholia
  7. Cell surface trafficking of the antidepressant-sensitive norepinephrine transporter revealed with an ectodomain antibody. Savchenko V, Sung U, Blakely RD. Mol Cell Neurosci. 2003 Dec;24(4):1131–50. PubMed Europe PMC Scholia
  8. Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area. Liprando LA, Miner LH, Blakely RD, Lewis DA, Sesack SR. Synapse. 2004 Jun 15;52(4):233–44. PubMed Europe PMC Scholia
  9. Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation. Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD. Mol Pharmacol. 2004 Jun;65(6):1462–74. PubMed Europe PMC Scholia
  10. p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process. Zhu CB, Carneiro AM, Dostmann WR, Hewlett WA, Blakely RD. J Biol Chem. 2005 Apr 22;280(16):15649–58. PubMed Europe PMC Scholia
  11. Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation. Jayanthi LD, Samuvel DJ, Blakely RD, Ramamoorthy S. Mol Pharmacol. 2005 Jun;67(6):2077–87. PubMed Europe PMC Scholia
  12. Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins. Sung U, Jennings JL, Link AJ, Blakely RD. Biochem Biophys Res Commun. 2005 Aug 5;333(3):671–8. PubMed Europe PMC Scholia
  13. Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase. Prasad HC, Zhu CB, McCauley JL, Samuvel DJ, Ramamoorthy S, Shelton RC, et al. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11545–50. PubMed Europe PMC Scholia
  14. Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex. Miner LH, Jedema HP, Moore FW, Blakely RD, Grace AA, Sesack SR. J Neurosci. 2006 Feb 1;26(5):1571–8. PubMed Europe PMC Scholia
  15. The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters. Zhu CB, Blakely RD, Hewlett WA. Neuropsychopharmacology. 2006 Oct;31(10):2121–31. PubMed Europe PMC Scholia
  16. Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter. Carneiro AMD, Blakely RD. J Biol Chem. 2006 Aug 25;281(34):24769–80. PubMed Europe PMC Scholia
  17. Na+, Cl-, and pH dependence of the human choline transporter (hCHT) in Xenopus oocytes: the proton inactivation hypothesis of hCHT in synaptic vesicles. Iwamoto H, Blakely RD, De Felice LJ. J Neurosci. 2006 Sep 27;26(39):9851–9. PubMed Europe PMC Scholia
  18. Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes. Dipace C, Sung U, Binda F, Blakely RD, Galli A. Mol Pharmacol. 2007 Jan;71(1):230–9. PubMed Europe PMC Scholia
  19. The functional impact of SLC6 transporter genetic variation. Hahn MK, Blakely RD. Annu Rev Pharmacol Toxicol. 2007;47:401–41. PubMed Europe PMC Scholia
  20. Calcium-dependent interactions of the human norepinephrine transporter with syntaxin 1A. Sung U, Blakely RD. Mol Cell Neurosci. 2007 Feb;34(2):251–60. PubMed Europe PMC Scholia
  21. Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine. Williams JM, Owens WA, Turner GH, Saunders C, Dipace C, Blakely RD, et al. PLoS Biol. 2007 Oct 16;5(10):e274. PubMed Europe PMC Scholia
  22. Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. Carneiro AMD, Cook EH, Murphy DL, Blakely RD. J Clin Invest. 2008 Apr;118(4):1544–52. PubMed Europe PMC Scholia
  23. Going with the flow: trafficking-dependent and -independent regulation of serotonin transport. Steiner JA, Carneiro AMD, Blakely RD. Traffic. 2008 Sep;9(9):1393–402. PubMed Europe PMC Scholia
  24. Anomalous dopamine release associated with a human dopamine transporter coding variant. Mazei-Robison MS, Bowton E, Holy M, Schmudermaier M, Freissmuth M, Sitte HH, et al. J Neurosci. 2008 Jul 9;28(28):7040–6. PubMed Europe PMC Scholia
  25. Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75. Hoard JL, Hoover DB, Mabe AM, Blakely RD, Feng N, Paolocci N. Neuroscience. 2008 Sep 22;156(1):129–42. PubMed Europe PMC Scholia
  26. Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes. Carneiro AMD, Airey DC, Thompson B, Zhu CB, Lu L, Chesler EJ, et al. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2047–52. PubMed Europe PMC Scholia