Pentose phosphate pathway (WP1231)

Anopheles gambiae

The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. This metabolic pathway is parallel to glycolysis. It generates NADPH and pentoses (5-carbon sugars) as well as ribose 5-phosphate, the last one a precursor for the synthesis of nucleotides. While it does involve oxidation of glucose, its primary role is anabolic rather than catabolic. The pathway is especially important in erythrocytes. There are two distinct phases in the pathway. The first is the oxidative phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars.


Friederike Ehrhart , Dan Lawson , Lotte Sevenich , Martina Summer-Kutmon , and Eric Weitz


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Anopheles gambiae



Pathway Ontology

pentose phosphate pathway


Label Type Compact URI Comment
Sedoheptulose-7-Phosphate Metabolite cas:2646-35-7
Fructose-6-Phosphate Metabolite cas:643-13-0
Xylulose-5-Phosphate Metabolite cas:60802-29-1
Glyceraldehyde-3-phosphate Metabolite hmdb:HMDB0001112
Ribose-5-Phosphate Metabolite cas:3615-55-2
6-Phosphogluconate Metabolite hmdb:HMDB0001316
Erythrose-4-Phosphate Metabolite hmdb:HMDB0001321
Ribulose-5-Phosphate Metabolite cas:4151-19-3
Glucose-6-Phosphate Metabolite cas:59-56-3
Glyceraldehyde-3-phosphate Metabolite hmdb:HMDB0001112
6-Phosphonoglucono-delta-lactone Metabolite hmdb:HMDB0001127
Fructose-6-Phosphate Metabolite hmdb:HMDB0000124
G6PD GeneProduct ensembl:AGAP012678
AgaP_AGAP010866 GeneProduct ncbigene:1271093
AgaP_AGAP005080 GeneProduct ncbigene:1274761
AgaP_AGAP011800 GeneProduct ncbigene:1280848
AgaP_AGAP011457 GeneProduct ncbigene:3291340
AgaP_AGAP004197 GeneProduct ncbigene:1274031