Wnt signaling pathway (WP539)

Mus musculus

Wnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Binding of Wnt to its receptors leads to activation of at least 3 distinct pathways: i) the canonical beta catenin pathway, ii) the planar cell polarity pathway, and, iii) the calcium pathway. In the canonical beta catenin pathway, binding of Wnt to its receptors leads to stabilization of beta catenin in the cytosol followed by its translocation into the nucleus where it activates the transcription factor Tcf/Lef leading to upregulation of target genes. The non canonical planar cell polarity pathway involves activation of Dishevelled, small G proteins (Rho/Rac) and JNK. The non canonical calcium pathway involves activation of calcium sensitive kinases, PKC and CAMKII by Dishevelled. The Wnt signaling pathway is similar to the Hedgehog pathway in many respects. Abnormalities in the Wnt signaling pathway are associated with a large variety of human malignancies including tumors of breast, colon, pancreas, liver and bone. Source: [http://www.netpath.org/pathways?path_id=NetPath_8 NetPath] '''Additional comments:''' This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, please cite the Cancer Cell Map and NetPath websites until the pathway is published.

Authors

Akhilesh Pandey , Thomas Kelder , Daniela Digles , Egon Willighagen , and Eric Weitz

Activity

last edited

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

Wnt signaling pathway

Participants

Label Type Compact URI Comment
Wnt3a GeneProduct ncbigene:22416
Wnt1 GeneProduct ncbigene:22408
Wnt2 GeneProduct ncbigene:22413
Lrp6 GeneProduct ncbigene:16974
Wnt4 GeneProduct ncbigene:22417
Sfrp1 GeneProduct ncbigene:20377
Lrp5 GeneProduct ncbigene:16973
Axin1 GeneProduct ncbigene:12005
Gsk3b GeneProduct ncbigene:56637
Fzd8 GeneProduct ncbigene:14370
Dkk1 GeneProduct ncbigene:13380
Dvl1 GeneProduct ncbigene:13542
Ror2 GeneProduct ncbigene:26564
Fzd5 GeneProduct ncbigene:14367
Wnt7a GeneProduct ncbigene:22421
Fzd2 GeneProduct ncbigene:57265
Lrp1 GeneProduct ncbigene:16971
Wnt5a GeneProduct ncbigene:22418
Arrb2 GeneProduct ncbigene:216869
Prkca GeneProduct ncbigene:18750
Prkcb1 GeneProduct ncbigene:18751
Fzd7 GeneProduct ncbigene:14369
Magi3 GeneProduct ncbigene:99470
Fzd4 GeneProduct ncbigene:14366
Ltap GeneProduct ncbigene:93840
Mapk8 GeneProduct ncbigene:26419
Map3k7 GeneProduct ncbigene:26409
HIPK2 GeneProduct ncbigene:15258
Nlk GeneProduct ncbigene:18099
Myb GeneProduct ncbigene:17863
Fzd1 GeneProduct ncbigene:14362
Cxxc4 GeneProduct ncbigene:319478
Csnk1d GeneProduct ncbigene:104318
Frat1 GeneProduct ncbigene:14296
Tcfe2a GeneProduct ncbigene:21423
Tcf4 GeneProduct ncbigene:21413
Pias4 GeneProduct ncbigene:59004
Sumo1 GeneProduct ncbigene:22218
Dvl2 GeneProduct ncbigene:13543
Rhoa GeneProduct ncbigene:11848
Daam1 GeneProduct ncbigene:208846
Csnk1e GeneProduct ncbigene:27373
Nkd1 GeneProduct ncbigene:93960
Brd7 GeneProduct ncbigene:26992
Dab2 GeneProduct ncbigene:13132
Ctnnb1 GeneProduct ncbigene:12387
Ep300 GeneProduct ncbigene:328572
Fhl2 GeneProduct ncbigene:14200
Csnk2a1 GeneProduct ncbigene:12995
Csnk2a2 GeneProduct ncbigene:13000
Csnk2b GeneProduct ncbigene:13001
Apc GeneProduct ncbigene:11789
Csnk1a1 GeneProduct ncbigene:93687
Arrb1 GeneProduct ncbigene:109689
Ctnnbip1 GeneProduct ncbigene:67087
Cdc25c GeneProduct ncbigene:12532
Cdc2a GeneProduct ncbigene:12534
Ppp2ca GeneProduct ncbigene:19052
Dvl3 GeneProduct ncbigene:13544
Mtap1b GeneProduct ncbigene:17755
Nr5a1 GeneProduct ncbigene:26423
Ctbp1 GeneProduct ncbigene:13016
Ctbp2 GeneProduct ncbigene:13017
Pax2 GeneProduct ncbigene:18504
Mapk8ip1 GeneProduct ncbigene:19099
Tbp GeneProduct ncbigene:21374
Axin2 GeneProduct ncbigene:12006
Sox1 GeneProduct ncbigene:20664
Sall1 GeneProduct ncbigene:58198
Akt1 GeneProduct ncbigene:11651
Bcl9 GeneProduct ncbigene:77578
Pin1 GeneProduct ncbigene:23988
Camk2a GeneProduct ncbigene:12322
Camk2b GeneProduct ncbigene:12323
Camk2g GeneProduct ncbigene:12325
Camk2d GeneProduct ncbigene:108058
Jup GeneProduct ncbigene:16480
Rac1 GeneProduct ncbigene:19353
Smad3 GeneProduct ncbigene:17127
Fzd6 GeneProduct ncbigene:14368
Sfrp2 GeneProduct ncbigene:20319
Btrc GeneProduct ncbigene:12234
Tcfap2a GeneProduct ncbigene:21418
Runx2 GeneProduct ncbigene:12393
Mark2 GeneProduct ncbigene:13728
Cul1 GeneProduct ncbigene:26965
Skp1a GeneProduct ncbigene:21402
Smad4 GeneProduct ncbigene:17128
Tax1bp3 GeneProduct ncbigene:76281
Cdh1 GeneProduct ncbigene:12550
Ruvbl1 GeneProduct ncbigene:56505
Frat2 GeneProduct ncbigene:212398
Dlgh4 GeneProduct ncbigene:13385
Dlgh2 GeneProduct ncbigene:23859
Dlgh1 GeneProduct ncbigene:13383
Lef1 GeneProduct ncbigene:16842
LOC665283 GeneProduct ncbigene:665283
Senp2 GeneProduct ncbigene:75826
Ccnd1 GeneProduct ncbigene:12443
Crybb2 GeneProduct ncbigene:12961
Jun GeneProduct ncbigene:16476
Mapk9 GeneProduct ncbigene:26420
Ankrd6 GeneProduct ncbigene:140577
Sox9 GeneProduct ncbigene:20682
Mapk3 GeneProduct ncbigene:26417
Mapk1 GeneProduct ncbigene:26413
Raf1 GeneProduct ncbigene:110157
Fzd9 GeneProduct ncbigene:14371
Wnt3 GeneProduct ncbigene:22415

References