Insulin signaling (WP1313)

Danio rerio

Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentation.

Authors

Kristina Hanspers , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Danio rerio

Communities

Annotations

Pathway Ontology

insulin signaling pathway

Participants

Label Type Compact URI Comment
stxbp2 GeneProduct ensembl:ENSDARG00000007603 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6813
pik3cd GeneProduct ensembl:ENSDARG00000003250 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5293
pik3c3 GeneProduct ensembl:ENSDARG00000054829 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5289
cyth3a GeneProduct ensembl:ENSDARG00000007807 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9265
ptprfa GeneProduct ensembl:ENSDARG00000103479 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5792
rac1b GeneProduct ensembl:ENSDARG00000087954 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5879
gsk3b GeneProduct ensembl:ENSDARG00000017803 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2932
mink1 GeneProduct ensembl:ENSDARG00000035360 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:50488
grb2a GeneProduct ensembl:ENSDARG00000105276 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2885
SHC3 GeneProduct ensembl:ENSDARG00000098909 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:53358
irs1 GeneProduct ensembl:ENSDARG00000054087 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3667
slc2a1b GeneProduct ensembl:ENSDARG00000007412 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6513
rps6ka4 GeneProduct ensembl:ENSDARG00000044436 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8986
ikbkb GeneProduct ensembl:ENSDARG00000079123 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3551
socs3a GeneProduct ensembl:ENSDARG00000104400 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9021
prkchb GeneProduct ensembl:ENSDARG00000043243 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5583
kif5bb GeneProduct ensembl:ENSDARG00000103394 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3799
irs1 GeneProduct ensembl:ENSDARG00000054087 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3667
ehd2a GeneProduct ensembl:ENSDARG00000035137 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:30846
arf6b GeneProduct ensembl:ENSDARG00000052928 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:382
gyg1a GeneProduct ensembl:ENSDARG00000011934 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2992
akt2 GeneProduct ensembl:ENSDARG00000011219 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:208
srfa GeneProduct ensembl:ENSDARG00000053918 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6722
map3k2 GeneProduct ensembl:ENSDARG00000062884 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10746
rab4a GeneProduct ensembl:ENSDARG00000019144 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5867
prkcdb GeneProduct ensembl:ENSDARG00000070651 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5580
akt1 GeneProduct ensembl:ENSDARG00000099657 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:207
cap1 GeneProduct ensembl:ENSDARG00000016350 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10487
rheb GeneProduct ensembl:ENSDARG00000090213 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6009
pfkma GeneProduct ensembl:ENSDARG00000014179 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5213
stxbp1a GeneProduct ensembl:ENSDARG00000001994 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6812
mapk12b GeneProduct ensembl:ENSDARG00000006409 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6300
pik3r1 GeneProduct ensembl:ENSDARG00000038524 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5295
map3k5 GeneProduct ensembl:ENSDARG00000005416 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4217
irs2a GeneProduct ensembl:ENSDARG00000037099 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8660
pik3c2g GeneProduct ensembl:ENSDARG00000099803 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5288
pik3r2 GeneProduct ensembl:ENSDARG00000018060 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5296
mapk10 GeneProduct ensembl:ENSDARG00000102730 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5602
map3k3 GeneProduct ensembl:ENSDARG00000060348 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4215
mapk3 GeneProduct ensembl:ENSDARG00000070573 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5595
ptenb GeneProduct ensembl:ENSDARG00000056623 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5728
elk1 GeneProduct ensembl:ENSDARG00000078066 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2002
shc1 GeneProduct ensembl:ENSDARG00000075437 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6464
crk GeneProduct ensembl:ENSDARG00000055635 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1398
trib3 GeneProduct ensembl:ENSDARG00000016200 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:57761
stxbp4 GeneProduct ensembl:ENSDARG00000076997 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:252983
rps6kal GeneProduct ensembl:ENSDARG00000037574 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:27330
insrb GeneProduct ensembl:ENSDARG00000071524 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3643
xbp1 GeneProduct ensembl:ENSDARG00000035622 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7494
foxo1b GeneProduct ensembl:ENSDARG00000061549 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2308
tbc1d4 GeneProduct ensembl:ENSDARG00000075156 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9882
prkcbb GeneProduct ensembl:ENSDARG00000022254 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5579
map2k7 GeneProduct ensembl:ENSDARG00000008279 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5609
sos1 GeneProduct ensembl:ENSDARG00000100503 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6654
rac2 GeneProduct ensembl:ENSDARG00000038010 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5880
fosab GeneProduct ensembl:ENSDARG00000031683 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2353
pik3cg GeneProduct ensembl:ENSDARG00000017757 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5294
rrad GeneProduct ensembl:ENSDARG00000052011 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6236
pik3ca GeneProduct ensembl:ENSDARG00000075456 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000121879
sgk3 GeneProduct ensembl:ENSDARG00000062460 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:23678
SH2B2 GeneProduct ensembl:ENSDARG00000090421 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10603
mapk13 GeneProduct ensembl:ENSDARG00000058470 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5603
gys1 GeneProduct ensembl:ENSDARG00000016875 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2997
TSC2 GeneProduct ensembl:ENSDARG00000103125 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7249
pik3cb GeneProduct ensembl:ENSDARG00000075253 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5291
map3k1 GeneProduct ensembl:ENSDARG00000098405 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4214
map4k3b GeneProduct ensembl:ENSDARG00000071357 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8491
enpp1 GeneProduct ensembl:ENSDARG00000005789 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5167
map2k6 GeneProduct ensembl:ENSDARG00000099184 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5608
arhgap33 GeneProduct ensembl:ENSDARG00000011333 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:115703
map3k8 GeneProduct ensembl:ENSDARG00000061710 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1326
pfklb GeneProduct ensembl:ENSDARG00000099755 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5211
tsc1a GeneProduct ensembl:ENSDARG00000026048 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7248
map3k12 GeneProduct ensembl:ENSDARG00000103651 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7786
rps6ka5 GeneProduct ensembl:ENSDARG00000060551 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9252
stx4 GeneProduct ensembl:ENSDARG00000052518 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6810
igf1ra GeneProduct ensembl:ENSDARG00000027423 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3480
prkcz GeneProduct ensembl:ENSDARG00000043332 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5590
snap25b GeneProduct ensembl:ENSDARG00000058117 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6616
map2k4a GeneProduct ensembl:ENSDARG00000063583 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6416
GRB14 GeneProduct ensembl:ENSDARG00000068280 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2888
prkcq GeneProduct ensembl:ENSDARG00000034173 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5588
rps6ka1 GeneProduct ensembl:ENSDARG00000033437 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6195
mapk7 GeneProduct ensembl:ENSDARG00000023110 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5598
rps6ka2 GeneProduct ensembl:ENSDARG00000028469 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6196
mapk14a GeneProduct ensembl:ENSDARG00000000857 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1432
rps6kb1a GeneProduct ensembl:ENSDARG00000018399 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6198
rhoq GeneProduct ensembl:ENSDARG00000025953 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:23433
MAP3K11 GeneProduct ensembl:ENSDARG00000091521 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4296
prkaa2 GeneProduct ensembl:ENSDARG00000060641 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5563
snap23.1 GeneProduct ensembl:ENSDARG00000012874 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8773
ptpn1 GeneProduct ensembl:ENSDARG00000007923 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5770
mapk8a GeneProduct ensembl:ENSDARG00000031888 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5599
inppl1a GeneProduct ensembl:ENSDARG00000104222 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3636
cblb GeneProduct ensembl:ENSDARG00000015199 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:868
map3k7 GeneProduct ensembl:ENSDARG00000020469 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6885
stxbp3 GeneProduct ensembl:ENSDARG00000008142 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6814
inpp4ab GeneProduct ensembl:ENSDARG00000070995 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3631
sgk1 GeneProduct ensembl:ENSDARG00000025522 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6446
cbl GeneProduct ensembl:ENSDARG00000009958 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:867
pik3r4 GeneProduct ensembl:ENSDARG00000060469 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:30849
mapk11 GeneProduct ensembl:ENSDARG00000045836 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5600
mapk9 GeneProduct ensembl:ENSDARG00000077364 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5601
ptpn11a GeneProduct ensembl:ENSDARG00000020334 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5781
gys2 GeneProduct ensembl:ENSDARG00000004904 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2998
jun GeneProduct ensembl:ENSDARG00000043531 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3725
socs1a GeneProduct ensembl:ENSDARG00000038095 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8651
mapk6 GeneProduct ensembl:ENSDARG00000032103 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5597
eif4ea GeneProduct ensembl:ENSDARG00000077012 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1977
shc2 GeneProduct ensembl:ENSDARG00000062080 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:25759
flot2b GeneProduct ensembl:ENSDARG00000069774 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2319
cblc GeneProduct ensembl:ENSDARG00000078217 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:23624
myo1cb GeneProduct ensembl:ENSDARG00000061579 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4641
gab1 GeneProduct ensembl:ENSDARG00000037018 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2549
rhoj GeneProduct ensembl:ENSDARG00000020250 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:57381
gsk3ab GeneProduct ensembl:ENSDARG00000015681 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2931
prkci GeneProduct ensembl:ENSDARG00000021225 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5584
prkaa1 GeneProduct ensembl:ENSDARG00000060596 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5562
sorbs1 GeneProduct ensembl:ENSDARG00000103435 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10580
sos2 GeneProduct ensembl:ENSDARG00000060506 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6655
MAP3K13 GeneProduct ensembl:ENSDARG00000009493 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9175
ppp1r3ab GeneProduct ensembl:ENSDARG00000088813 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5506
raf1a GeneProduct ensembl:ENSDARG00000096415 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5894
mtor GeneProduct ensembl:ENSDARG00000053196 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2475
PRKCA GeneProduct ensembl:ENSDARG00000099841 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5578
lipeb GeneProduct ensembl:ENSDARG00000101145 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3991
mapk4 GeneProduct ensembl:ENSDARG00000017681 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5596
map4k6 GeneProduct ensembl:ENSDARG00000033444 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5871
pdpk1a GeneProduct ensembl:ENSDARG00000062304 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5170
hrasa GeneProduct ensembl:ENSDARG00000098497 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3265
rapgef1a GeneProduct ensembl:ENSDARG00000043593 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2889
foxo3b GeneProduct ensembl:ENSDARG00000042904 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2309
map2k5 GeneProduct ensembl:ENSDARG00000011851 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5607
grb10a GeneProduct ensembl:ENSDARG00000002013 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2887
egr1 GeneProduct ensembl:ENSDARG00000037421 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1958
map3k10 GeneProduct ensembl:ENSDARG00000055672 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4294
vamp2 GeneProduct ensembl:ENSDARG00000056877 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6844
pik3c2a GeneProduct ensembl:ENSDARG00000060841 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5286
mapk1 GeneProduct ensembl:ENSDARG00000027552 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5594
flot1b GeneProduct ensembl:ENSDARG00000037998 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10211
pik3ca GeneProduct ensembl:ENSDARG00000075456 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5290
map2k1 GeneProduct ensembl:ENSDARG00000007825 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5604
MAP3K6 GeneProduct ensembl:ENSDARG00000104760 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9064
sgk2a GeneProduct ensembl:ENSDARG00000063370 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10110
map3k4 GeneProduct ensembl:ENSDARG00000104835 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4216
map3k9 GeneProduct ensembl:ENSDARG00000013491 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4293
kif3a GeneProduct ensembl:ENSDARG00000087538 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:11127
map4k5 GeneProduct ensembl:ENSDARG00000039125 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:11183
map2k2a GeneProduct ensembl:ENSDARG00000006609 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5605
mapk8a GeneProduct ensembl:ENSDARG00000031888 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5599
map3k14a GeneProduct ensembl:ENSDARG00000074060 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9020

References

  1. A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation. Quon MJ, Campfield LA. J Theor Biol. 1991 May 7;150(1):93–107. PubMed Europe PMC Scholia
  2. Insulin signalling. Bevan P. J Cell Sci. 2001 Apr;114(Pt 8):1429–30. PubMed Europe PMC Scholia
  3. Insulin signalling and the regulation of glucose and lipid metabolism. Saltiel AR, Kahn CR. Nature. 2001 Dec 13;414(6865):799–806. PubMed Europe PMC Scholia