Farnesyl to CoQ10 metabolism (WP5274)

Homo sapiens

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Coenzyme Q (ubiquinone or CoQ) is an essential lipid in electron transport and an important antioxidant. CoQ synthesis derives from the isoprene biosynthetic pathway in human and yeast cells. There is interest in the use of CoQ10 in particular for the treatment of mitochondrial disorders and neurodegenerative diseases [PMID: 17973981].

Authors

Denise Slenter

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

classic metabolic pathway isoprenoid biosynthetic pathway metabolic pathway of cofactors, vitamins, nutrients

Participants

Label Type Compact URI Comment
Decaprenyl-4OH-benzoate Metabolite pubchem.compound:6454686 AKA Decaprenyl-4-hydroxybenzoate
tyrosine Metabolite chebi:18186
Decarprenyl-PP Metabolite pubchem.compound:46173330 AKA decarprenyl pyrophosphate
Farnesyl-PP Metabolite chebi:175763
4OH-Cinnamate Metabolite pubchem.compound:637542 AKA 4-Hydroxycinnamic acid
CoQ10 Metabolite chebi:46245
4OH-phenyllactate Metabolite hmdb:HMDB0000755 AKA 4-Hydroxyphenyllactate
Hydroxyphenyllactic acid is a tyrosine metabolite. It is carcinogenic. The level of hydroxyphenyllactic acid is elevated in patients with deficiency of the enzyme p-hydroxyphenylpyruvate oxidase (EC 1.14.2.2) PMID:4720815]
4OH-phenylpyruvate Metabolite chebi:15999 AKA 4-Hydroxyphenylpyruvic acid (4-HPPA)
4OH-benzoate Metabolite pubchem.compound:135 AKA 4-Hydroxybenzoic acid
Trans-prenyl transferase Protein eccode:2.5.1.- Might be 2.5.1.90 and/or 2.5.1.91

References

  1. Ubiquinone: cholesterol’s reclusive cousin. Hargreaves IP. Ann Clin Biochem. 2003 May;40(Pt 3):207–18. PubMed Europe PMC Scholia
  2. Vanillic Acid Restores Coenzyme Q Biosynthesis and ATP Production in Human Cells Lacking COQ6. Acosta Lopez MJ, Trevisson E, Canton M, Vazquez-Fonseca L, Morbidoni V, Baschiera E, et al. Oxid Med Cell Longev. 2019 Jul 10;2019:3904905. PubMed Europe PMC Scholia