IL-2 signaling pathway (WP450)

Mus musculus

IL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions related to B cell proliferation, and cytolytic activity of natural killer cells. IL-2 also activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation-induced cell death. More recently, IL-2 was shown to promote tolerance through its effects on regulatory T cell development. IL-2 clinically has anti-cancer effects as well as utility in supporting T cell numbers in HIV/AIDS. There are three classes of IL-2 receptors, binding IL-2 with low, intermediate, or high-affinity. The low affinity receptor (IL-2Rα alone) is not functional; signaling by IL-2 involves either the high affinity hetero-trimeric receptor containing IL-2Rα, IL-2Rβ and the common cytokine receptor gamma chain (originally named IL-2Rγ and now generally denoted as γc) or the intermediate affinity heterodimeric receptor composed of IL-2Rβ and γc. IL-2 stimulation induces the activation of the Janus family tyrosine kinases JAK1 and JAK3, which associate with IL-2Rβ and γc, respectively. These kinases in turn phosphorylate IL-2Rβ and induce tyrosine phosphorylation of STATs (signal transducers and activators of transcription) and various other downstream targets. The downstream signaling pathways activated by IL-2 also involves mitogen-activated protein kinase and phosphoinositide 3-kinase signaling modules, leading to both mitogenic and anti-apoptotic signals. Please access this pathway at [ NetSlim] database. NetPath is a collaborative project between PandeyLab at Johns Hopkins University ( and the Institute of Bioinformatics ( If you use this pathway, please cite the NetPath website until the pathway is published.


Akhilesh Pandey , Kristina Hanspers , Christine Chichester , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz


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Mus musculus



Pathway Ontology

interleukin-2 signaling pathway


Label Type Compact URI Comment
Il2rg GeneProduct ncbigene:16186
Il2rb GeneProduct ncbigene:16185
Il2ra GeneProduct ncbigene:16184
Il2 GeneProduct ncbigene:16183
Il2 GeneProduct ncbigene:16183
Il2 GeneProduct ncbigene:16183
Jak1 GeneProduct ncbigene:16451
Jak3 GeneProduct ncbigene:16453
Jak2 GeneProduct ncbigene:16452
Lck GeneProduct ncbigene:16818
Pik3r1 GeneProduct ncbigene:18708
Pik3r2 GeneProduct ncbigene:18709
Ptpn6 GeneProduct ncbigene:15170
Mapk1 GeneProduct ncbigene:26413
Mapk3 GeneProduct ncbigene:26417
Gab2 GeneProduct ncbigene:14389
Syk GeneProduct ncbigene:20963
Irs1 GeneProduct ncbigene:16367
Irs2 GeneProduct ncbigene:384783
Stam2 GeneProduct ncbigene:56324
Stam GeneProduct ncbigene:20844
Socs3 GeneProduct ncbigene:12702
Plcb1 GeneProduct ncbigene:18795
Rps6kb1 GeneProduct ncbigene:72508
Pik3ca GeneProduct ncbigene:18706
Pik3cb GeneProduct ncbigene:74769
Pik3cd GeneProduct ncbigene:18707
Pik3cg GeneProduct ncbigene:30955
Fyn GeneProduct ncbigene:14360
Akt1 GeneProduct ncbigene:11651
Foxo3 GeneProduct ncbigene:56484
Tert GeneProduct ncbigene:21752
Lyn GeneProduct ncbigene:17096
Ptpn11 GeneProduct ncbigene:19247
Shc1 GeneProduct ncbigene:20416
Raf1 GeneProduct ncbigene:110157
Grb2 GeneProduct ncbigene:14784
Ptk2b GeneProduct ncbigene:19229
Cd53 GeneProduct ncbigene:12508
Icam1 GeneProduct ncbigene:15894
Sos1 GeneProduct ncbigene:20662
Socs1 GeneProduct ncbigene:12703
Cish GeneProduct ncbigene:12700
Gnb2l1 GeneProduct ncbigene:14694
Crkl GeneProduct ncbigene:12929
Cbl GeneProduct ncbigene:12402
Shb GeneProduct ncbigene:230126
Crk GeneProduct ncbigene:12928
Nmi GeneProduct ncbigene:64685
Ets1 GeneProduct ncbigene:23871
Ets2 GeneProduct ncbigene:23872
Nr3c1 GeneProduct ncbigene:14815
Prkcz GeneProduct ncbigene:18762
Itm2b GeneProduct ncbigene:16432
Bcl2 GeneProduct ncbigene:12043
Ifna1 GeneProduct ncbigene:15962
Mtor GeneProduct ncbigene:56717
Hsp90aa1 GeneProduct ncbigene:15519
Mknk1 GeneProduct ncbigene:17346
Eif4e GeneProduct ncbigene:13684
Creb1 GeneProduct ncbigene:12912
Map2k1 GeneProduct ncbigene:26395
Map2k2 GeneProduct ncbigene:26396
Vav1 GeneProduct ncbigene:22324
Stat5a GeneProduct ncbigene:20850
Stat5b GeneProduct ncbigene:20851
Mapk1 GeneProduct ncbigene:26413
Mapk3 GeneProduct ncbigene:26417
Nfkb1 GeneProduct ncbigene:18033
Rela GeneProduct ncbigene:19697
Ybx1 GeneProduct ncbigene:22608
Nfkb1 GeneProduct ncbigene:18033
Rela GeneProduct ncbigene:19697
Ybx1 GeneProduct ncbigene:22608
Tert GeneProduct ncbigene:21752
Akt1 GeneProduct ncbigene:11651
Raf1 GeneProduct ncbigene:110157
Kras GeneProduct ncbigene:16653
Mapk8 GeneProduct ncbigene:26419
Mapk14 GeneProduct ncbigene:26416
Mapkapk2 GeneProduct ncbigene:17164
Mapk9 GeneProduct ncbigene:26420
Chuk GeneProduct ncbigene:12675
Eif3b GeneProduct ncbigene:27979
Akt1 GeneProduct ncbigene:11651
Stat3 GeneProduct ncbigene:20848
Stat5a GeneProduct ncbigene:20850
Stat5b GeneProduct ncbigene:20851
Stat1 GeneProduct ncbigene:20846
Crk GeneProduct ncbigene:12928
Il2 GeneProduct ncbigene:16183
Il2 GeneProduct ncbigene:16183