IL-2 signaling pathway (WP1091)

Canis familiaris

IL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions related to B cell proliferation, and cytolytic activity of natural killer cells. IL-2 also activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation-induced cell death. More recently, IL-2 was shown to promote tolerance through its effects on regulatory T cell development. IL-2 clinically has anti-cancer effects as well as utility in supporting T cell numbers in HIV/AIDS. There are three classes of IL-2 receptors, binding IL-2 with low, intermediate, or high-affinity. The low affinity receptor (IL-2Rα alone) is not functional; signaling by IL-2 involves either the high affinity hetero-trimeric receptor containing IL-2Rα, IL-2Rβ and the common cytokine receptor gamma chain (originally named IL-2Rγ and now generally denoted as γc) or the intermediate affinity heterodimeric receptor composed of IL-2Rβ and γc. IL-2 stimulation induces the activation of the Janus family tyrosine kinases JAK1 and JAK3, which associate with IL-2Rβ and γc, respectively. These kinases in turn phosphorylate IL-2Rβ and induce tyrosine phosphorylation of STATs (signal transducers and activators of transcription) and various other downstream targets. The downstream signaling pathways activated by IL-2 also involves mitogen-activated protein kinase and phosphoinositide 3-kinase signaling modules, leading to both mitogenic and anti-apoptotic signals. Please access this pathway at [ NetSlim] database. NetPath is a collaborative project between PandeyLab at Johns Hopkins University ( and the Institute of Bioinformatics ( If you use this pathway, please cite the NetPath website until the pathway is published.


Christine Chichester , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz


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Canis familiaris



Pathway Ontology

interleukin-2 signaling pathway


Label Type Compact URI Comment
IL2 GeneProduct ncbigene:403989
STAT5B GeneProduct ncbigene:490969
JAK3 GeneProduct ncbigene:610004
VAV1 GeneProduct ncbigene:485016
STAT1 GeneProduct ncbigene:488449
CREB1 GeneProduct ncbigene:607922
ETS2 GeneProduct ncbigene:487761
LYN GeneProduct ncbigene:477886
AKT1 GeneProduct ncbigene:490878
TERT GeneProduct ncbigene:403412
CISH GeneProduct ncbigene:484757
ETS1 GeneProduct ncbigene:489287
PTPN11 GeneProduct ncbigene:477488
GNB2L1 GeneProduct ncbigene:480818
SOCS1 GeneProduct ncbigene:490006
STAT5A GeneProduct ncbigene:490968
SHB GeneProduct ncbigene:481619
PIK3CD GeneProduct ncbigene:489644
EIF4E GeneProduct ncbigene:487870
STAM GeneProduct ncbigene:477990
LCK GeneProduct ncbigene:478151
IL2RB GeneProduct ncbigene:403439
IL2RA GeneProduct ncbigene:403870
RAF1 GeneProduct ncbigene:484648
CD53 GeneProduct ncbigene:610454
ICAM1 GeneProduct ncbigene:403975
IL2 GeneProduct ncbigene:403989
MTOR GeneProduct ncbigene:478232
AKT1 GeneProduct ncbigene:490878
EIF3B GeneProduct ncbigene:479766
JAK1 GeneProduct ncbigene:442952
GRB2 GeneProduct ncbigene:483312
TERT GeneProduct ncbigene:403412
MAP2K1 GeneProduct ncbigene:478347
SYK GeneProduct ncbigene:484196
BCL2 GeneProduct ncbigene:403416
MKNK1 GeneProduct ncbigene:482509
STAT5A GeneProduct ncbigene:490968
PIK3R1 GeneProduct ncbigene:487235
SOCS3 GeneProduct ncbigene:442949
PIK3CB GeneProduct ncbigene:477085
ITM2B GeneProduct ncbigene:476916
MAPK8 GeneProduct ncbigene:477746
AKT1 GeneProduct ncbigene:490878
GAB2 GeneProduct ncbigene:485167
STAT3 GeneProduct ncbigene:490967
CHUK GeneProduct ncbigene:477796
PTK2B GeneProduct ncbigene:486102
JAK2 GeneProduct ncbigene:484185
YBX1 GeneProduct ncbigene:479011
PIK3R2 GeneProduct ncbigene:609956
NR3C1 GeneProduct ncbigene:478047
PLCB1 GeneProduct ncbigene:485773
RELA GeneProduct ncbigene:483729
IL2 GeneProduct ncbigene:403989
PIK3CA GeneProduct ncbigene:488084
IL2RG GeneProduct ncbigene:403851
STAM2 GeneProduct ncbigene:476150
NFKB1 GeneProduct ncbigene:442859
PRKCZ GeneProduct ncbigene:479577
IL2 GeneProduct ncbigene:403989
STAT5B GeneProduct ncbigene:490969
MAP2K2 GeneProduct ncbigene:611939
NMI GeneProduct ncbigene:476146
FYN GeneProduct ncbigene:475032
HRAS GeneProduct ncbigene:403735
MAPK9 GeneProduct ncbigene:474652
MAPKAPK2 GeneProduct ncbigene:490263
MAPK1 GeneProduct ncbigene:477575
YBX1 GeneProduct ncbigene:479011
RPS6KB1 GeneProduct ncbigene:480580
PIK3CG GeneProduct ncbigene:483266
IL2 GeneProduct ncbigene:403989
RAF1 GeneProduct ncbigene:484648
CRKL GeneProduct ncbigene:608125
MAPK1 GeneProduct ncbigene:477575
SOS1 GeneProduct ncbigene:483042
NFKB1 GeneProduct ncbigene:442859
MAPK14 GeneProduct ncbigene:403856
LOC480438 GeneProduct ncbigene:480438
MAPK3 GeneProduct ncbigene:486758
IRS1 GeneProduct ncbigene:486148
RELA GeneProduct ncbigene:483729
MAPK3 GeneProduct ncbigene:486758
PTPN6 GeneProduct ncbigene:486717
SHC1 GeneProduct ncbigene:490439
IRS2 GeneProduct ncbigene:485548


  1. NetPath: a public resource of curated signal transduction pathways. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia