Cell cycle and cell division (WP414)

Saccharomyces cerevisiae

(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.


Nathan Salomonis , Bruce Conklin , Martijn Van Iersel , Stephanie Widdison , Christine Chichester , Egon Willighagen , Martina Summer-Kutmon , Kristina Hanspers , Ado , and Eric Weitz


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Saccharomyces cerevisiae



Pathway Ontology

cell cycle pathway, mitotic


Label Type Compact URI Comment
Phosphate Metabolite cas:14265-44-2
Cyclic AMP Metabolite hmdb:HMDB0000058
Grr1 GeneProduct sgd:S000003850
Rad9 GeneProduct sgd:S000002625
Dbf2 GeneProduct sgd:S000003324
Hsl7 GeneProduct sgd:S000000337
Met30 GeneProduct sgd:S000001308
Clb1 GeneProduct sgd:S000003340
Bub1 GeneProduct sgd:S000003420
Rad9 GeneProduct sgd:S000002625
Pds1 GeneProduct sgd:S000002520
Smc2 GeneProduct sgd:S000001927
Cdc28 GeneProduct sgd:S000000364
Gin4 GeneProduct sgd:S000002915
Rad24 GeneProduct sgd:S000000975
Bub3 GeneProduct sgd:S000005552
Mih1 GeneProduct sgd:S000004639
Cdc16 GeneProduct sgd:S000001505
Cdc53 GeneProduct sgd:S000002290
Smc4 GeneProduct sgd:S000004076
Hsl1 GeneProduct sgd:S000001584
Crt1 GeneProduct sgd:S000003746
Cdc34 GeneProduct sgd:S000002461
Ssn6 GeneProduct sgd:S000000316
Fus3 GeneProduct sgd:S000000112
Apc2 GeneProduct sgd:S000004117
Cdc53 GeneProduct sgd:S000002290
Orc5 GeneProduct sgd:S000005205
Ycg1 GeneProduct sgd:S000002733
Mbp1 GeneProduct sgd:S000002214
Cdc28 GeneProduct sgd:S000000364
Dbf20 GeneProduct sgd:S000006315
Mec3 GeneProduct sgd:S000004279
Cdc34 GeneProduct sgd:S000002461
Bub2 GeneProduct sgd:S000004659
Apc9 GeneProduct sgd:S000004092
Cdc14 GeneProduct sgd:S000001924
Mps1 GeneProduct sgd:S000002186
Pcl1 GeneProduct sgd:S000005233
Rad26 GeneProduct sgd:S000003796
Sic1 GeneProduct sgd:S000004069
Sic1 GeneProduct sgd:S000004069
Cdc5 GeneProduct sgd:S000004603
Cdc34 GeneProduct sgd:S000002461
Orc1 GeneProduct sgd:S000004530
Orc3 GeneProduct sgd:S000003927
Mob1 GeneProduct sgd:S000001368
Skp1 GeneProduct sgd:S000002736
Cdc23 GeneProduct sgd:S000001209
Scc2 GeneProduct sgd:S000002588
Clb5 GeneProduct sgd:S000006324
Cdc5 GeneProduct sgd:S000004603
Tup1 GeneProduct sgd:S000000680
Cdc28 GeneProduct sgd:S000000364
Rad25 GeneProduct sgd:S000001405
Cdc54 GeneProduct sgd:S000006223
Brn1 GeneProduct sgd:S000000193
Sco1 GeneProduct sgd:S000000241
Skp1 GeneProduct sgd:S000002736
Dbf4 GeneProduct sgd:S000002459
Esp1 GeneProduct sgd:S000003330
Loc7 GeneProduct sgd:S000004262
Mcm6 GeneProduct sgd:S000003169
Cks1 GeneProduct sgd:S000000339
Cdc27 GeneProduct sgd:S000000180
Swi5 GeneProduct sgd:S000002553
Swi4 GeneProduct sgd:S000000913
Cdc4 GeneProduct sgd:S000001885
Pho2 GeneProduct sgd:S000002264
Mcm3 GeneProduct sgd:S000000758
Mcm2 GeneProduct sgd:S000000119
Apc4 GeneProduct sgd:S000002525
Pho80 GeneProduct sgd:S000005361
Clb3 GeneProduct sgd:S000002314
Pho4 GeneProduct sgd:S000001930
Chk1 GeneProduct sgd:S000000478
Cdc7 GeneProduct sgd:S000002175
Apc1 GeneProduct sgd:S000005116
Rad24 GeneProduct sgd:S000000975
Cdc28 GeneProduct sgd:S000000364
Pho81 GeneProduct sgd:S000003465
Far1 GeneProduct sgd:S000003693
Cdc53 GeneProduct sgd:S000002290
Mad2 GeneProduct sgd:S000003567
Cdc45 GeneProduct sgd:S000004093
Swi6 GeneProduct sgd:S000004172
Orc4 GeneProduct sgd:S000006366
Swe1 GeneProduct sgd:S000003723
Cdh1 GeneProduct sgd:S000002971
Pho85 GeneProduct sgd:S000005952
Pho85 GeneProduct sgd:S000005952
Pds1 GeneProduct sgd:S000002520
Cdc6 GeneProduct sgd:S000003730
Swi6 GeneProduct sgd:S000004172
Cak1 GeneProduct sgd:S000001865
Cdc20 GeneProduct sgd:S000003084
Dam1 GeneProduct sgd:S000003345
Rad53 GeneProduct sgd:S000006074
Rad1 GeneProduct sgd:S000005943
Uba1 GeneProduct sgd:S000001693
Rad17 GeneProduct sgd:S000005895
Cdc28 GeneProduct sgd:S000000364
Cdc15 GeneProduct sgd:S000000072
Cdc46 GeneProduct sgd:S000004264
Skp1 GeneProduct sgd:S000002736
Esc5 GeneProduct sgd:S000003612
Doc1 GeneProduct sgd:S000003209
Cln3 GeneProduct sgd:S000000038
Dcd1 GeneProduct sgd:S000006115
Cdc47 GeneProduct sgd:S000000406
Mad1 GeneProduct sgd:S000003054
Rad9 GeneProduct sgd:S000002625
Byr4 GeneProduct sgd:S000003814
Mad3 GeneProduct sgd:S000003550
Cln1 GeneProduct sgd:S000004812
Orc6 GeneProduct sgd:S000001160
Orc2 GeneProduct sgd:S000000264
Apc5 GeneProduct sgd:S000005775
Mec1 GeneProduct sgd:S000000340
Cdc26 GeneProduct sgd:S000001932
Hus1 GeneProduct sgd:S000005424
Apc11 GeneProduct sgd:S000002166
Tem1 GeneProduct sgd:S000004529
Lte1 GeneProduct sgd:S000000022
Pho5 GeneProduct sgd:S000000297


  1. Chromosome segregation: dual control ensures fidelity. Taylor SS. Curr Biol. 1999;9(15):R562-4. PubMed Europe PMC Scholia
  2. Kinase signaling in the spindle checkpoint. Kang J, Yu H. J Biol Chem. 2009 Jun 5;284(23):15359–63. PubMed Europe PMC Scholia