BDNF pathway (WP2152)

Mus musculus

Brain-derived neurotrophic factor (BDNF) is a growth factor found in the central and peripheral nervous systems. BDNF binds to two well-characterized receptors, TrkB and p75 (aka, low-affinity nerve growth factor receptor) to influence neuronal cell survival and differentiation. In the hippocampus, BDNF activity is also implicated in learning and memory.


Aaron Kolder , Martina Summer-Kutmon , Kristina Hanspers , Egon Willighagen , Alex Pico , and Eric Weitz


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Mus musculus



Pathway Ontology

brain-derived neurotrophic factor signaling pathway


Label Type Compact URI Comment
tPA GeneProduct ensembl:ENSMUSG00000031538
Pro-Bdnf GeneProduct ensembl:ENSMUSG00000048482
TrkB GeneProduct ensembl:ENSMUSG00000055254
Bcl2 - Cell survival GeneProduct ensembl:ENSMUSG00000057329
Frs2 GeneProduct ensembl:ENSMUSG00000020170
p53 GeneProduct ensembl:ENSMUSG00000059552
Plasminogen GeneProduct ensembl:ENSMUSG00000059481
Mapk GeneProduct ensembl:ENSMUSG00000024558
Creb GeneProduct ensembl:ENSMUSG00000025958
Rac1 GeneProduct ensembl:ENSMUSG00000001847
Bax GeneProduct ensembl:ENSMUSG00000003873
Shc1 GeneProduct ensembl:ENSMUSG00000042626
Cdc42 GeneProduct ensembl:ENSMUSG00000006699
p75 GeneProduct ensembl:ENSMUSG00000000120
PAI-1 GeneProduct ensembl:ENSMUSG00000037411
Bdnf GeneProduct ensembl:ENSMUSG00000048482
Plasmin GeneProduct ensembl:ENSMUSG00000059481


  1. Extinction of rac1 and Cdc42Hs signalling defines a novel p53-dependent apoptotic pathway. Lassus P, Roux P, Zugasti O, Philips A, Fort P, Hibner U. Oncogene. 2000 May 11;19(20):2377–85. PubMed Europe PMC Scholia
  2. p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway. Thomas A, Giesler T, White E. Oncogene. 2000 Nov 2;19(46):5259–69. PubMed Europe PMC Scholia
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  4. Apoptosis: controlled demolition at the cellular level. Taylor RC, Cullen SP, Martin SJ. Nat Rev Mol Cell Biol. 2008 Mar;9(3):231–41. PubMed Europe PMC Scholia
  5. Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-3 through NFkB and MAPK dependent pathways in rat astrocytes [corrected]. Thompson WL, Van Eldik LJ. Brain Res. 2009 Sep 1;1287:47–57. PubMed Europe PMC Scholia
  6. SH2B regulation of growth, metabolism, and longevity in both insects and mammals. Song W, Ren D, Li W, Jiang L, Cho KW, Huang P, et al. Cell Metab. 2010 May 5;11(5):427–37. PubMed Europe PMC Scholia
  7. FGF2 promotes Msx2 stimulated PC-1 expression via Frs2/MAPK signaling. Li Y, Liu J, Hudson M, Kim S, Hatch NE. J Cell Biochem. 2010 Dec 1;111(5):1346–58. PubMed Europe PMC Scholia
  8. Prenatal stress differentially alters brain-derived neurotrophic factor expression and signaling across rat strains. Neeley EW, Berger R, Koenig JI, Leonard S. Neuroscience. 2011 Jul 28;187:24–35. PubMed Europe PMC Scholia
  9. Neuroprotection by urokinase plasminogen activator in the hippocampus. Cho E, Lee KJ, Seo JW, Byun CJ, Chung SJ, Suh DC, et al. Neurobiol Dis. 2012 Apr;46(1):215–24. PubMed Europe PMC Scholia