Apoptosis modulation by HSP70 (WP487)

Rattus norvegicus

This pathway summarizes the various ways by which HSP70 proteins can inhibit apoptosis.


Ismael Reyes , Siddarth , Christine Chichester , Martina Summer-Kutmon , Kristina Hanspers , Egon Willighagen , and Eric Weitz


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Rattus norvegicus



Pathway Ontology

apoptotic cell death pathway


Label Type Compact URI Comment
Apaf1 GeneProduct ncbigene:78963
Hspa1a GeneProduct ncbigene:24472
Map3k1 GeneProduct ncbigene:116667
Faslg GeneProduct ensembl:ENSRNOG00000002978
Tnfrsf1a GeneProduct ncbigene:25625
Hspa1a GeneProduct ncbigene:24472
Hspa1a GeneProduct ncbigene:24472
Casp3 GeneProduct ncbigene:25402
Casp8 GeneProduct ncbigene:64044
Cycs GeneProduct ncbigene:25309
Bid GeneProduct ncbigene:64625
Nfkb1 GeneProduct ncbigene:81736
Fadd GeneProduct ncbigene:266610
Casp9 GeneProduct ncbigene:58918
Mapk10 GeneProduct ncbigene:25272
Pdcd8 GeneProduct ncbigene:83533 Apoptosis Inducing Factor
Fadd GeneProduct ncbigene:266610
Casp8 GeneProduct ncbigene:64044
Ripk1 GeneProduct ncbigene:306886
Casp2 GeneProduct ncbigene:64314
Casp7 GeneProduct ncbigene:64026
Casp6 GeneProduct ncbigene:83584
Fas GeneProduct ensembl:ENSRNOG00000019142
Cycs GeneProduct ncbigene:25309


  1. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M. EMBO J. 1998 Nov 2;17(21):6124–34. PubMed Europe PMC Scholia
  2. Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. FEBS Lett. 1998 Oct 30;438(1–2):1–4. PubMed Europe PMC Scholia
  3. Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. Schett G, Steiner CW, Gröger M, Winkler S, Graninger W, Smolen J, et al. FASEB J. 1999 May;13(8):833–42. PubMed Europe PMC Scholia
  4. Negative regulation of the Apaf-1 apoptosome by Hsp70. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES. Nat Cell Biol. 2000 Aug;2(8):476–83. PubMed Europe PMC Scholia
  5. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, et al. Mol Cell Biol. 2000 Oct;20(19):7146–59. PubMed Europe PMC Scholia
  6. HSP27 and HSP70: potentially oncogenic apoptosis inhibitors. Garrido C, Schmitt E, Candé C, Vahsen N, Parcellier A, Kroemer G. Cell Cycle. 2003;2(6):579–84. PubMed Europe PMC Scholia
  7. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, et al. Oncogene. 2003 Oct 2;22(43):6669–78. PubMed Europe PMC Scholia
  8. The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, et al. J Biol Chem. 2004 Jun 11;279(24):25689–95. PubMed Europe PMC Scholia