Proteasome degradation (WP183)

Homo sapiens

Degradation by proteasomes is part of the mechanism by which cells regulate the concentration of proteins and degrade misfolded proteins. Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Proteins are tagged for degradation by proteasomes by the addition of ubiquitin, by ubiquitin ligases. Description adapted from [ Wikipedia]. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Nathan Salomonis , Frank Dennissen , Thomas Kelder , Martijn Van Iersel , Kristina Hanspers , Chris Evelo , Egon Willighagen , Martina Summer-Kutmon , Mick Eikelhof , and Eric Weitz


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Homo sapiens



Pathway Ontology

ubiquitin/proteasome degradation pathway


Label Type Compact URI Comment
ATP Metabolite cas:1927-31-7
PSMB10 GeneProduct ncbigene:5699
UBC GeneProduct ncbigene:7316
HIST1H2AB GeneProduct ncbigene:8335
UCHL3 GeneProduct ensembl:ENSG00000118939
PSMA2 GeneProduct ncbigene:5683
HLA-G GeneProduct ncbigene:3135
PSME1 GeneProduct ncbigene:5720
PSMB1 GeneProduct ncbigene:5689
PSMA5 GeneProduct ncbigene:5686
HLA-E GeneProduct ncbigene:3133
PSMD12 GeneProduct ncbigene:5718
PSMD9 GeneProduct ncbigene:5715
PSMC5 GeneProduct ncbigene:5705 PRS6 HUMAN
UBE2B GeneProduct ncbigene:7320
PSMB8 GeneProduct ncbigene:5696
PSMD7 GeneProduct ncbigene:5713
PSMB4 GeneProduct ncbigene:5692
UBE2D3 GeneProduct ncbigene:7323
PSMD11 GeneProduct ncbigene:5717
UBE1 GeneProduct ncbigene:7317
RPN1 GeneProduct ncbigene:6184
PSMC3 GeneProduct ncbigene:5702
H2AFZ GeneProduct ncbigene:3015
PSMB2 GeneProduct ncbigene:5690
HLA-H GeneProduct ncbigene:3136
PSMB9 GeneProduct ncbigene:5698
IFNG GeneProduct ncbigene:3458
PSMA3 GeneProduct ncbigene:5684
UCHL1 GeneProduct ensembl:ENSG00000154277
HLA-A GeneProduct ncbigene:3105
PSMD10 GeneProduct ncbigene:5716
HLA-J GeneProduct ncbigene:3137
HLA-F GeneProduct ncbigene:3134
PSMD3 GeneProduct ncbigene:5709
PSMD13 GeneProduct ncbigene:5719
UBE2D2 GeneProduct ncbigene:7322
RPN2 GeneProduct ncbigene:6185
H2AFX GeneProduct ncbigene:3014
PSMD6 GeneProduct ncbigene:9861
PSMA7 GeneProduct ncbigene:5688
PSMA1 GeneProduct ncbigene:5682
UBE1L GeneProduct ncbigene:7318
PSMB6 GeneProduct ncbigene:5694 U13393
PSMA6 GeneProduct ncbigene:5687
PSMB5 GeneProduct ncbigene:5693
PSME3 GeneProduct ncbigene:10197
PSMC1 GeneProduct ncbigene:5700
PSMD5 GeneProduct ncbigene:5711
UBE2D1 GeneProduct ncbigene:7321
NEDD4 GeneProduct ncbigene:4734
PSMC6 GeneProduct ncbigene:5706
PSMC4 GeneProduct ncbigene:5704 PRS6 HUMAN
PSMD4 GeneProduct ncbigene:5710
UBB GeneProduct ensembl:ENSG00000170315
HLA-C GeneProduct ncbigene:3107
PSMA4 GeneProduct ncbigene:5685
PSME2 GeneProduct ncbigene:5721
PSMB7 GeneProduct ncbigene:5695
PSMD1 GeneProduct ncbigene:5707
PSMC2 GeneProduct ncbigene:5701
HLA-B GeneProduct ncbigene:3106
PSMB3 GeneProduct ncbigene:5691
PSMD2 GeneProduct ncbigene:5708
PSMD8 GeneProduct ncbigene:5714
PSMC5 GeneProduct ncbigene:5705
Ubiquitin Protein uniprot:P0CG48


  1. Basic Medical Research Award. The ubiquitin system. Hershko A, Ciechanover A, Varshavsky A. Nat Med. 2000 Oct;6(10):1073–81. PubMed Europe PMC Scholia
  2. Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Lasker K, Förster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, et al. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1380–7. PubMed Europe PMC Scholia