Neural crest differentiation (WP2074)

Mus musculus

Gene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involved involved in neural crest and downstream progenitor specification. Transcriptional regulation arrows are proposed to promote transcription, unless a graphical T-bar is present at the end of the arrow (commented to be inhibitors of transcriptional regulation). Additional gene information was obtained from When citing thies pathway, please reference the source publication (PMID: 19575671).


Kristina Hanspers , Alex Pico , Andra Waagmeester , Egon Willighagen , Laurent Winckers , and Eric Weitz


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Mus musculus



Cell Type Ontology

migratory cranial neural crest cell neural crest derived neuron migratory cranial neural crest cell

Pathway Ontology

regulatory pathway


Label Type Compact URI Comment
Bmp7 GeneProduct ensembl:ENSMUSG00000008999
Rhob GeneProduct ensembl:ENSMUSG00000054364
Myb GeneProduct ensembl:ENSMUSG00000019982
Itgb1 GeneProduct ensembl:ENSMUSG00000025809
Wnt1 GeneProduct ensembl:ENSMUSG00000022997
Tcfap2a GeneProduct ensembl:ENSMUSG00000021359
Zic1 GeneProduct ensembl:ENSMUSG00000032368
Pax3 GeneProduct ensembl:ENSMUSG00000004872
Pax7 GeneProduct ensembl:ENSMUSG00000028736
Dlx5 GeneProduct ensembl:ENSMUSG00000029755
Msx3 GeneProduct ensembl:ENSMUSG00000025469
Msx2 GeneProduct ensembl:ENSMUSG00000021469
Foxd3 GeneProduct ensembl:ENSMUSG00000067261
Snai1 GeneProduct ensembl:ENSMUSG00000042821
Snai2 GeneProduct ensembl:ENSMUSG00000022676
Wnt3a GeneProduct ensembl:ENSMUSG00000009900
Fzd3 GeneProduct ensembl:ENSMUSG00000007989
Gsk3b GeneProduct ensembl:ENSMUSG00000022812
Ctnnb1 GeneProduct ensembl:ENSMUSG00000006932
Tcf7l1 GeneProduct ensembl:ENSMUSG00000055799
Tcf4 GeneProduct ensembl:ENSMUSG00000053477
Gbx2 GeneProduct ensembl:ENSMUSG00000034486
Axin2 GeneProduct ensembl:ENSMUSG00000000142
Axin1 GeneProduct ensembl:ENSMUSG00000024182
Dvl3 GeneProduct ensembl:ENSMUSG00000003233
Dvl2 GeneProduct ensembl:ENSMUSG00000020888
Dvl1 GeneProduct ensembl:ENSMUSG00000029071
Bmp4 GeneProduct ensembl:ENSMUSG00000021835
Smad1 GeneProduct ensembl:ENSMUSG00000031681
Id1 GeneProduct ensembl:ENSMUSG00000042745
Notch1 GeneProduct ensembl:ENSMUSG00000026923
Dll3 GeneProduct ensembl:ENSMUSG00000003436
Notch4 GeneProduct ensembl:ENSMUSG00000015468
Notch2 GeneProduct ensembl:ENSMUSG00000027878
Dll4 GeneProduct ensembl:ENSMUSG00000027314
Notch3 GeneProduct ensembl:ENSMUSG00000038146
Dll1 GeneProduct ensembl:ENSMUSG00000014773
Hey2 GeneProduct ensembl:ENSMUSG00000019789
Twist1 GeneProduct ensembl:ENSMUSG00000035799
Sox10 GeneProduct ensembl:ENSMUSG00000033006
Fgf2 GeneProduct ensembl:ENSMUSG00000037225
Hes5 GeneProduct ensembl:ENSMUSG00000048001
Hes1 GeneProduct ensembl:ENSMUSG00000022528
Rbpj GeneProduct ensembl:ENSMUSG00000039191
Hes5 GeneProduct ensembl:ENSMUSG00000048001
Hes1 GeneProduct ensembl:ENSMUSG00000022528
Fgfr1 GeneProduct ensembl:ENSMUSG00000031565
Fgfr2 GeneProduct ensembl:ENSMUSG00000030849
Fgfr3 GeneProduct ensembl:ENSMUSG00000054252
Zic5 GeneProduct ensembl:ENSMUSG00000041703
Bmyc GeneProduct ensembl:ENSMUSG00000049086
Sox9 GeneProduct ensembl:ENSMUSG00000000567
Sox10 GeneProduct ensembl:ENSMUSG00000033006
Isl1 GeneProduct ensembl:ENSMUSG00000042258
Cdh6 GeneProduct ensembl:ENSMUSG00000039385
Cdh2 GeneProduct ensembl:ENSMUSG00000024304
Cdh1 GeneProduct ensembl:ENSMUSG00000000303
Sox5 GeneProduct ensembl:ENSMUSG00000041540
Ets1 GeneProduct ensembl:ENSMUSG00000032035
Pax3 GeneProduct ensembl:ENSMUSG00000004872
Pax7 GeneProduct ensembl:ENSMUSG00000028736
Nfkb1 GeneProduct ensembl:ENSMUSG00000028163
Cdh7 GeneProduct ensembl:ENSMUSG00000026312
Tcfap2a GeneProduct ensembl:ENSMUSG00000021359
Snai1 GeneProduct ensembl:ENSMUSG00000042821
Snai2 GeneProduct ensembl:ENSMUSG00000022676
Foxd3 GeneProduct ensembl:ENSMUSG00000067261
Id1 GeneProduct ensembl:ENSMUSG00000042745
Sox9 GeneProduct ensembl:ENSMUSG00000000567
Nfkb2 GeneProduct ensembl:ENSMUSG00000025225
Neurog1 GeneProduct ensembl:ENSMUSG00000048904
Sox10 GeneProduct ensembl:ENSMUSG00000033006
Phox2b GeneProduct ensembl:ENSMUSG00000012520
Gfap GeneProduct ensembl:ENSMUSG00000020932
Olig1 GeneProduct ensembl:ENSMUSG00000046160
Olig2 GeneProduct ensembl:ENSMUSG00000039830
Gjb1 GeneProduct ensembl:ENSMUSG00000047797
Ascl1 GeneProduct ensembl:ENSMUSG00000020052
Mitf GeneProduct ensembl:ENSMUSG00000035158
Pmp22 GeneProduct ensembl:ENSMUSG00000018217
Mpz GeneProduct ensembl:ENSMUSG00000056569
Mbp GeneProduct ensembl:ENSMUSG00000041607
Foxd3 GeneProduct ensembl:ENSMUSG00000067261
Pax3 GeneProduct ensembl:ENSMUSG00000004872
Lhx1 GeneProduct ensembl:ENSMUSG00000018698
Lhx2 GeneProduct ensembl:ENSMUSG00000000247
Bmp4 GeneProduct ensembl:ENSMUSG00000021835
Fgf8 GeneProduct ensembl:ENSMUSG00000025219
Fgf15 GeneProduct ensembl:ENSMUSG00000031073
Sox10 GeneProduct ensembl:ENSMUSG00000033006
Pax3 GeneProduct ensembl:ENSMUSG00000004872
Pax7 GeneProduct ensembl:ENSMUSG00000028736
Sox5 GeneProduct ensembl:ENSMUSG00000041540
Mitf GeneProduct ensembl:ENSMUSG00000035158
Hdac1 GeneProduct ensembl:ENSMUSG00000028800
Hdac2 GeneProduct ensembl:ENSMUSG00000019777
Hdac3 GeneProduct ensembl:ENSMUSG00000024454
Hdac4 GeneProduct ensembl:ENSMUSG00000026313
Hdac5 GeneProduct ensembl:ENSMUSG00000008855
Hdac6 GeneProduct ensembl:ENSMUSG00000031161
Hdac7 GeneProduct ensembl:ENSMUSG00000022475
Hdac8 GeneProduct ensembl:ENSMUSG00000067567
Hdac9 GeneProduct ensembl:ENSMUSG00000004698
Hdac10 GeneProduct ensembl:ENSMUSG00000062906
Hdac11 GeneProduct ensembl:ENSMUSG00000034245
Ctbp2 GeneProduct ensembl:ENSMUSG00000030970
Dct GeneProduct ensembl:ENSMUSG00000022129
Sox5 GeneProduct ensembl:ENSMUSG00000041540
Sox9 GeneProduct ensembl:ENSMUSG00000000567
Col2a1 GeneProduct ensembl:ENSMUSG00000022483
Col11a2 GeneProduct ensembl:ENSMUSG00000024330
Mia1 GeneProduct ensembl:ENSMUSG00000089661
Wnt8a GeneProduct ensembl:ENSMUSG00000012282
Hoxb1 GeneProduct ensembl:ENSMUSG00000018973
Prtg GeneProduct ensembl:ENSMUSG00000036030
Olig3 GeneProduct ensembl:ENSMUSG00000045591
Tbx6 GeneProduct ensembl:ENSMUSG00000030699
Hoxa1 GeneProduct ensembl:ENSMUSG00000029844
Lhx5 GeneProduct ensembl:ENSMUSG00000029595
Tlx2 GeneProduct ensembl:ENSMUSG00000068327
Tcfap2b GeneProduct ensembl:ENSMUSG00000025927
Dmbx1 GeneProduct ensembl:ENSMUSG00000028707
Hand1 GeneProduct ensembl:ENSMUSG00000037335


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