COVID-19 adverse outcome pathway (WP4891)
Homo sapiens
Experimenting with links in line with bioinformatics analysis of COVID-19 genes and AOP knowledge. Work in progress!
Authors
Penny Nymark , Friederike Ehrhart , Egon Willighagen , Chris Evelo , and Eric WeitzActivity
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Cited In
- Identifying Drug-Induced Liver Injury Associated With Inflammation-Drug and Drug-Drug Interactions in Pharmacologic Treatments for COVID-19 by Bioinformatics and System Biology Analyses: The Role of Pregnane X Receptor (2022).
- Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients (2022).
- AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMC (2022).
- Identification of Robust Protein Associations With COVID-19 Disease Based on Five Clinical Studies (2022).
- Systematic Organization of COVID-19 Data Supported by the Adverse Outcome Pathway Framework (2021).
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Organisms
Homo sapiensCommunities
Adverse Outcome Pathways COVID-19Annotations
Disease Ontology
severe acute respiratory syndrome pulmonary fibrosis viral infectious disease COVID-19Pathway Ontology
respiratory system disease pathway signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| CCL3 | GeneProduct | ncbigene:6348 | |
| TNF | GeneProduct | ncbigene:7124 | |
| IL2 | GeneProduct | ncbigene:3558 | |
| CSF3 | GeneProduct | ncbigene:1440 | |
| IL8 | GeneProduct | ncbigene:3576 | |
| CXCL10 | GeneProduct | ncbigene:3627 | |
| IL6 | GeneProduct | ncbigene:3569 | |
| IL7 | GeneProduct | ncbigene:3574 | |
| IL1B | GeneProduct | ncbigene:3553 | |
| CCL2 | GeneProduct | ncbigene:6347 | |
| IL10 | GeneProduct | ncbigene:3586 | |
| IL2RA | GeneProduct | ncbigene:3559 | |
| AGT | GeneProduct | ncbigene:183 | |
| TMPRSS2 | GeneProduct | ncbigene:7113 | |
| ACE2 | GeneProduct | ncbigene:59272 |
References
- A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, et al. Circ Res. 2000 Sep 1;87(5):E1-9. PubMed Europe PMC Scholia
- Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes. Labib S, Williams A, Yauk CL, Nikota JK, Wallin H, Vogel U, et al. Part Fibre Toxicol. 2016 Mar 15;13:15. PubMed Europe PMC Scholia
- A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions. Nymark P, Rieswijk L, Ehrhart F, Jeliazkova N, Tsiliki G, Sarimveis H, et al. Toxicol Sci. 2018 Mar 1;162(1):264–75. PubMed Europe PMC Scholia