Fatty acid biosynthesis (WP38)

Caenorhabditis elegans

The fatty acid synthesis of the roundworm C. Elegans is a highly conserved pathway evolutionary. This pathways is therefore of great importance to understand fat synthesis and nutrient sensing in adiposity regulation, which is key to understand the molecular mechanism behind obesity.


Kdahlquist , Chris Evelo , Egon Willighagen , Christine Chichester , Lauren J. Dupuis , Eric Weitz , Friederike Ehrhart , Denise Slenter , and Alex Pico


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Caenorhabditis elegans


Lipids and LIPID MAPS


Pathway Ontology

fatty acid biosynthetic pathway


Label Type Compact URI Comment
oxaloacetate Metabolite chebi:16452
3-ketoacyl-CoA Metabolite chebi:57347
Acetyl-CoA Metabolite hmdb:HMDB01206
Malonyl-CoA Metabolite hmdb:HMDB01175
Palmitate Metabolite chebi:15756
pyruvate Metabolite chebi:15361
citrate Metabolite chebi:133748
C32E8.9 GeneProduct ncbigene:171951
F32H2.5 GeneProduct ncbigene:172715
acs-17 GeneProduct ncbigene:180859
F32H2.5 GeneProduct ncbigene:172715
F32H2.5 GeneProduct ncbigene:172715
Y25C1A.13 GeneProduct ncbigene:173657
F32H2.5 GeneProduct ncbigene:172715
Y65B4BL.5 GeneProduct ncbigene:171643
pyc-1 GeneProduct ncbigene:179616
F53C11.3 GeneProduct ncbigene:179872
ech-2 GeneProduct ncbigene:3564942
C36A4.9 GeneProduct ncbigene:175500
D1005.1 GeneProduct ncbigene:180485
fat-5 GeneProduct ncbigene:180162
W09H1.5 GeneProduct ncbigene:174963
F54C8.1 GeneProduct ncbigene:186222
F32H2.5 GeneProduct ncbigene:172715
ech-6 GeneProduct ncbigene:176376
F32H2.5 GeneProduct ncbigene:172715
F37C12.7 GeneProduct ncbigene:176005
F32H2.5 GeneProduct ncbigene:172715
Thiolases GeneProduct ncbigene:176756
F32H2.5 GeneProduct ncbigene:172715


  1. Fat synthesis and adiposity regulation in Caenorhabditis elegans. Watts JL. Trends Endocrinol Metab. 2009 Mar;20(2):58–65. PubMed Europe PMC Scholia