p53 pathway (WP655)

Rattus norvegicus

p53 (also known as protein 53 or tumor protein 53), is a transcription factor which in humans is encoded by the TP53 gene. p53 is important in multicellular organisms, where it regulates the cell cycle and thus functions as a tumor suppressor that is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome," "the guardian angel gene," and the "master watchman," referring to its role in conserving stability by preventing genome mutation.


Kevin Hermans , Martijn Van Iersel , Kristina Hanspers , Daniela Digles , and Martina Summer-Kutmon


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Rattus norvegicus



Pathway Ontology

p53 signaling pathway


Label Type Compact Identifier Comment
p53 GeneProduct ensembl:ENSRNOG00000010756
Mdm2 GeneProduct ncbigene:314856
Mdm-X GeneProduct ensembl:ENSRNOG00000009696
p14ARF GeneProduct ncbigene:25163
ATR GeneProduct ncbigene:300944
Atm GeneProduct ncbigene:300711
Chek2 GeneProduct ncbigene:114212
Chek1 GeneProduct ncbigene:140583
p21 GeneProduct ncbigene:114851
14-3-3-σ GeneProduct ncbigene:298795
Rprm GeneProduct ncbigene:680110
Gadd45a GeneProduct ncbigene:25112
B99 GeneProduct ncbigene:300126
Fas GeneProduct ncbigene:246097
Bax GeneProduct ncbigene:24887
Pigs GeneProduct ncbigene:300514
scotin GeneProduct ncbigene:301013
IGF-BP3 GeneProduct ncbigene:24484
PAI GeneProduct ncbigene:24617
Pten GeneProduct ncbigene:50557
Mdm2 GeneProduct ncbigene:314856
Noxa GeneProduct ncbigene:492821
PERP GeneProduct ncbigene:292949
Adgrb1 GeneProduct ensembl:ENSRNOG00000029450
p53R2 GeneProduct ensembl:ENSRNOG00000025454
Tsc2 GeneProduct ncbigene:24855
Cdk4/6 GeneProduct ncbigene:114483
Cyclin E GeneProduct ncbigene:25729
Cdk2 GeneProduct ncbigene:362817
Cyclin B GeneProduct ncbigene:25203
Cdc2a GeneProduct ncbigene:54237
Casp8 GeneProduct ncbigene:64044
PAG608 GeneProduct ncbigene:64394
Igf1 GeneProduct ncbigene:24482
KAI GeneProduct ncbigene:83628
Gadd45a GeneProduct ncbigene:25112
IGF-BP3 GeneProduct ncbigene:24484
PIRH-2 GeneProduct ncbigene:289508
Bid GeneProduct ncbigene:64625
Siah GeneProduct ncbigene:140941
Sestrins GeneProduct ensembl:ENSRNOG00000000302
Cyclin G GeneProduct ncbigene:25405
Siah1a GeneProduct ncbigene:140941
Maspin GeneProduct ncbigene:116589
Wip1 GeneProduct ncbigene:287585
CytC GeneProduct ncbigene:25309
Apaf-1 GeneProduct ncbigene:78963
p73 GeneProduct ncbigene:362675
Casp9 GeneProduct ncbigene:58918
Casp3 GeneProduct ncbigene:25402


  1. p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile. Nelson DM, Bhaskaran V, Foster WR, Lehman-McKeeman LD. Toxicol Sci. 2006 Dec;94(2):272–80. PubMed Europe PMC Scholia
  2. The genetics of the p53 pathway, apoptosis and cancer therapy. Vazquez A, Bond EE, Levine AJ, Bond GL. Nat Rev Drug Discov. 2008 Dec;7(12):979–87. PubMed Europe PMC Scholia