Eukaryotic transcription initiation (WP518)

Caenorhabditis elegans

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: [[wikipedia:Transcription_(genetics)|Wikipedia]]


Nathan Salomonis , Thomas Kelder , Christine Chichester , and Eric Weitz


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Caenorhabditis elegans



Pathway Ontology

transcription pathway


Label Type Compact URI Comment
tbp-1 GeneProduct ncbigene:176054
ttb-1 GeneProduct ncbigene:178544
taf-6.1 GeneProduct ncbigene:173498
taf-7.2 GeneProduct ncbigene:176686
pat-4 GeneProduct ncbigene:175175
taf-13 GeneProduct ncbigene:192052
ZK550.4 GeneProduct ncbigene:178502
Y111B2A.13 GeneProduct ncbigene:176682
Y39B6A.36 GeneProduct ncbigene:180243
F54D5.11 GeneProduct ncbigene:174765
cdk-7 GeneProduct ncbigene:171784
R02D3.3 GeneProduct ncbigene:176838
Y66D12A.15 GeneProduct ncbigene:176584
Y50D7A.2 GeneProduct ncbigene:175190
F14B4.3 GeneProduct ncbigene:172752
F09F7.3 GeneProduct ncbigene:175767
ama-1 GeneProduct ncbigene:177190
C06A1.5 GeneProduct ncbigene:174630
C36B1.3 GeneProduct ncbigene:172680
H27M09.2 GeneProduct ncbigene:172412
ZK856.10 GeneProduct ncbigene:179418
Y77E11A.6 GeneProduct ncbigene:176950
Y48E1A.1 GeneProduct ncbigene:175015
Y97E10AR.5 GeneProduct ncbigene:179178
Y54E10BR.6 GeneProduct ncbigene:171877
F26F4.11 GeneProduct ncbigene:175660
W01G7.3 GeneProduct ncbigene:175056
rpb-2 GeneProduct ncbigene:175668
cyh-1 GeneProduct ncbigene:190078
mnat-1 GeneProduct ncbigene:173602


  1. Regulation of gene expression by TBP-associated proteins. Lee TI, Young RA. Genes Dev. 1998 May 15;12(10):1398–408. PubMed Europe PMC Scholia
  2. Orchestrated response: a symphony of transcription factors for gene control. Lemon B, Tjian R. Genes Dev. 2000 Oct 15;14(20):2551–69. PubMed Europe PMC Scholia