Eukaryotic transcription initiation (WP1182)

Canis familiaris

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: [[wikipedia:Transcription_(genetics)|Wikipedia]]


Thomas Kelder , Christine Chichester , and Eric Weitz


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Canis familiaris



Pathway Ontology

transcription pathway


Label Type Compact URI Comment
TBP GeneProduct ncbigene:611193
GTF2B GeneProduct ncbigene:479960
TAF5 GeneProduct ncbigene:100688981
TAF6 GeneProduct ncbigene:489846
TAF7 GeneProduct ncbigene:487180
TAF9 GeneProduct ncbigene:480815
ILK GeneProduct ncbigene:476836
TAF12 GeneProduct ncbigene:609994
TAF13 GeneProduct ncbigene:100688743
GTF2E1 GeneProduct ncbigene:488002
GTF2A2 GeneProduct ncbigene:478327
GTF2F2 GeneProduct ncbigene:609164
LOC100855770 GeneProduct ncbigene:100855770
CDK7 GeneProduct ncbigene:608441
GTF2H1 GeneProduct ncbigene:476881
GTF2H2 GeneProduct ncbigene:478089
LOC100856712 GeneProduct ncbigene:100856712
ERCC3 GeneProduct ncbigene:476105
ERCC2 GeneProduct ncbigene:493995
LOC100856298 GeneProduct ncbigene:100856298
POLR3B GeneProduct ncbigene:474531
POLR2A GeneProduct ncbigene:479483
POLR2F GeneProduct ncbigene:474512
POLR2C GeneProduct ncbigene:478109
POLR2E GeneProduct ncbigene:611859
LOC100688583 GeneProduct ncbigene:100688583
LOC100856457 GeneProduct ncbigene:100856457
POLR3E GeneProduct ncbigene:608689
POLR3H GeneProduct ncbigene:607850
POLR3K GeneProduct ncbigene:611625
POLR1A GeneProduct ncbigene:475766
POLR2I GeneProduct ncbigene:476476
POLR2G GeneProduct ncbigene:476052
POLR2H GeneProduct ncbigene:478656
LOC100686835 GeneProduct ncbigene:100686835
POLR2B GeneProduct ncbigene:475152
CCNH GeneProduct ncbigene:479156
MNAT1 GeneProduct ncbigene:480346
GTF2H3 GeneProduct ncbigene:477446
POLR1E GeneProduct ncbigene:474767
POLR1D GeneProduct ncbigene:100686016


  1. Regulation of gene expression by TBP-associated proteins. Lee TI, Young RA. Genes Dev. 1998 May 15;12(10):1398–408. PubMed Europe PMC Scholia
  2. Orchestrated response: a symphony of transcription factors for gene control. Lemon B, Tjian R. Genes Dev. 2000 Oct 15;14(20):2551–69. PubMed Europe PMC Scholia