Serotonin transporter activity (WP3138)
Bos taurus
Serotonin is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract (GI tract), blood platelets, and the central nervous system (CNS) of animals, including humans. It is popularly thought to be a contributor to feelings of well-being and happiness. This pathway summarizes the role of the antidepressant-sensitive serotonin (5-HT) transporter SERT (encoded by the SLC6A4 gene).
Authors
Martina Summer-Kutmon , Linda Rieswijk , Egon Willighagen , Eric Weitz , Alex Pico , and Denise SlenterActivity
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Organisms
Bos taurusCommunities
Annotations
Cell Type Ontology
neuronPathway Ontology
serotonin signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Serotonin | Metabolite | hmdb:HMDB0000259 | |
| L-Tryptophan | Metabolite | hmdb:HMDB0000929 | |
| Citalopram | Metabolite | hmdb:HMDB0005038 | |
| SCAMP2 | GeneProduct | ensembl:ENSBTAG00000005844 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10066 |
| TGFB1I1 | GeneProduct | ensembl:ENSBTAG00000002391 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7041 |
| SLC6A4 | GeneProduct | ensembl:ENSBTAG00000019349 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6532 |
| INTB3 | GeneProduct | ensembl:ENSBTAG00000009987 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3690 |
| IL1B | GeneProduct | ensembl:ENSBTAG00000001321 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553 |
| PPP2CB | GeneProduct | ensembl:ENSBTAG00000009245 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5516 |
| STX1A | GeneProduct | ensembl:ENSBTAG00000017075 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6804 |
| MAOA | GeneProduct | ensembl:ENSBTAG00000016206 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4128 |
| NOS1 | GeneProduct | ensembl:ENSBTAG00000002023 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4842 |
| TPH2 | GeneProduct | ensembl:ENSBTAG00000020792 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:121278 |
| IL1R1 | GeneProduct | ensembl:ENSBTAG00000005273 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3554 |
References
- Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter. Carneiro AMD, Blakely RD. J Biol Chem. 2006 Aug 25;281(34):24769–80. PubMed Europe PMC Scholia
- Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Chanrion B, Mannoury la Cour C, Bertaso F, Lerner-Natoli M, Freissmuth M, Millan MJ, et al. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8119–24. PubMed Europe PMC Scholia
- Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. Carneiro AMD, Cook EH, Murphy DL, Blakely RD. J Clin Invest. 2008 Apr;118(4):1544–52. PubMed Europe PMC Scholia