Oxidative stress response (WP408)

Homo sapiens

Oxidative stress represents an imbalance between the production and manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of tissues can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Some reactive oxidative species can even act as messengers through a phenomenon called redox signaling. In humans, oxidative stress is involved in many diseases. Examples include Sickle Cell Disease,[1] atherosclerosis, Parkinson's disease, heart failure, myocardial infarction, Alzheimer's disease, Schizophrenia, Bipolar disorder, fragile X syndrome[2] and chronic fatigue syndrome, but short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis.[3] Reactive oxygen species can be beneficial, as they are used by the immune system as a way to attack and kill pathogens. Source: Wikipedia ([[wikipedia:Oxidative_stress]]) Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP408 CPTAC Assay Portal]


Niradiz Reyes , Kristina Hanspers , Ismael Reyes , KHALID RASHID , Alex Pico , Martijn Van Iersel , Egon Willighagen , Xuyongdeng , Harald Schmidt , and Eric Weitz


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Homo sapiens



Pathway Ontology

oxidative stress response pathway


Label Type Compact URI Comment
Reactive Oxygen Species Metabolite chebi:26523
MGST1 GeneProduct ncbigene:4257
SP1 GeneProduct ncbigene:6667
SOD2 GeneProduct ncbigene:6648
NFKB1 GeneProduct ncbigene:4790
MT1X GeneProduct ncbigene:4501
NFIX GeneProduct ncbigene:4784
NOX1 GeneProduct ensembl:ENSG00000007952
MAPK10 GeneProduct ncbigene:5602
NFE2L2 GeneProduct ensembl:ENSG00000116044
GCLC GeneProduct ncbigene:2729
HMOX1 GeneProduct ncbigene:3162
MAPK14 GeneProduct ncbigene:1432
TXNRD2 GeneProduct ncbigene:10587
FOS GeneProduct ncbigene:2353
CAT GeneProduct ncbigene:847
CYP1A1 GeneProduct ncbigene:1543
JUNB GeneProduct ncbigene:3726
GSTT2 GeneProduct ncbigene:2953
SOD3 GeneProduct ncbigene:6649
GPX1 GeneProduct ncbigene:2876
NOX4 GeneProduct ncbigene:50507
XDH GeneProduct ncbigene:7498
TXNRD1 GeneProduct ncbigene:7296
GPX3 GeneProduct ncbigene:2878
UGT1A6 GeneProduct ncbigene:54578
MAOA GeneProduct ncbigene:4128
GSR GeneProduct ncbigene:2936
TXN2 GeneProduct ncbigene:25828
NQO1 GeneProduct ncbigene:1728
SOD1 GeneProduct ncbigene:6647
CYBB GeneProduct ensembl:ENSG00000165168
NOX3 GeneProduct ensembl:ENSG00000074771
NOX5 GeneProduct ensembl:ENSG00000255346


  1. Repression of gene expression by oxidative stress. Morel Y, Barouki R. Biochem J. 1999 Sep 15;342 Pt 3(Pt 3):481–96. PubMed Europe PMC Scholia