Oxidative stress response (WP408)
Homo sapiens
Oxidative stress represents an imbalance between the production and manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of tissues can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Some reactive oxidative species can even act as messengers through a phenomenon called redox signaling. In humans, oxidative stress is involved in many diseases. Examples include sickle cell disease,[1] atherosclerosis, Parkinson's disease, heart failure, myocardial infarction, Alzheimer's disease, schizophrenia, bipolar disorder, fragile X syndrome[2] and chronic fatigue syndrome, but short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis.[3] Reactive oxygen species can be beneficial, as they are used by the immune system as a way to attack and kill pathogens. Source: Wikipedia ([[wikipedia:Oxidative_stress]]) Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP408 CPTAC Assay Portal]
Authors
Niradiz Reyes , Kristina Hanspers , Ismael Reyes , KHALID RASHID , Alex Pico , Martijn Van Iersel , Egon Willighagen , Xuyongdeng , Harald Schmidt , and Eric WeitzActivity
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Cited In
- Early transcriptional responses of bronchial epithelial cells to whole cigarette smoke mirror those of in-vivo exposed human bronchial mucosa (2022).
- Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease (2021).
- Investigating the Molecular Processes behind the Cell-Specific Toxicity Response to Titanium Dioxide Nanobelts (2021).
- Heterogeneity of Lipid and Protein Cartilage Profiles Associated with Human Osteoarthritis with or without Type 2 Diabetes Mellitus (2021).
- Induced pluripotent stem cell–based mapping of β-globin expression throughout human erythropoietic development (2018).
- Transcriptional Analysis of T Cells Resident in Human Skin (2016).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
oxidative stress response pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Reactive oxygen species | Metabolite | chebi:26523 | |
| MGST1 | GeneProduct | ncbigene:4257 | |
| SP1 | GeneProduct | ncbigene:6667 | |
| SOD2 | GeneProduct | ncbigene:6648 | |
| NFKB1 | GeneProduct | ncbigene:4790 | |
| MT1X | GeneProduct | ncbigene:4501 | |
| NFIX | GeneProduct | ncbigene:4784 | |
| NOX1 | GeneProduct | ensembl:ENSG00000007952 | |
| MAPK10 | GeneProduct | ncbigene:5602 | |
| NFE2L2 | GeneProduct | ensembl:ENSG00000116044 | |
| GCLC | GeneProduct | ncbigene:2729 | |
| HMOX1 | GeneProduct | ncbigene:3162 | |
| MAPK14 | GeneProduct | ncbigene:1432 | |
| TXNRD2 | GeneProduct | ncbigene:10587 | |
| FOS | GeneProduct | ncbigene:2353 | |
| CAT | GeneProduct | ncbigene:847 | |
| CYP1A1 | GeneProduct | ncbigene:1543 | |
| JUNB | GeneProduct | ncbigene:3726 | |
| GSTT2 | GeneProduct | ncbigene:2953 | |
| SOD3 | GeneProduct | ncbigene:6649 | |
| GPX1 | GeneProduct | ncbigene:2876 | |
| NOX4 | GeneProduct | ncbigene:50507 | |
| XDH | GeneProduct | ncbigene:7498 | |
| TXNRD1 | GeneProduct | ncbigene:7296 | |
| GPX3 | GeneProduct | ncbigene:2878 | |
| UGT1A6 | GeneProduct | ncbigene:54578 | |
| MAOA | GeneProduct | ncbigene:4128 | |
| GSR | GeneProduct | ncbigene:2936 | |
| TXN2 | GeneProduct | ncbigene:25828 | |
| NQO1 | GeneProduct | ncbigene:1728 | |
| SOD1 | GeneProduct | ncbigene:6647 | |
| CYBB | GeneProduct | ensembl:ENSG00000165168 | |
| NOX3 | GeneProduct | ensembl:ENSG00000074771 | |
| NOX5 | GeneProduct | ensembl:ENSG00000255346 |
References
- Repression of gene expression by oxidative stress. Morel Y, Barouki R. Biochem J. 1999 Sep 15;342 Pt 3(Pt 3):481–96. PubMed Europe PMC Scholia