Mitochondrial complex I inhibition leading to parkinsonian motor deficits (WP4945)

Homo sapiens

This pathway is a meta-pathway that represents an updated version of the Adverse Outcome Pathway (AOP) of Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits [ AOP-Wiki:3]. All Key Events are present as Key Event nodes, with their corresponding molecular pathways as pathway nodes.


Marvin Martens , Eric Weitz , and Finterly Hu


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens


Adverse Outcome Pathways Diseases


Pathway Ontology

altered energy metabolic pathway

Disease Ontology

Parkinson's disease


Label Type Compact URI Comment


  1. An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition. Terron A, Bal-Price A, Paini A, Monnet-Tschudi F, Bennekou SH, EFSA WG EPI1 Members, et al. Arch Toxicol. 2018 Jan;92(1):41–82. PubMed Europe PMC Scholia