Mitochondrial complex I inhibition leading to parkinsonian motor deficits (WP4945)
This pathway is a meta-pathway that represents an updated version of the Adverse Outcome Pathway (AOP) of Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits [https://aopwiki.org/aops/3 AOP-Wiki:3]. All Key Events are present as Key Event nodes, with their corresponding molecular pathways as pathway nodes.
AuthorsMarvin Martens , Eric Weitz , and Finterly Hu
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CommunitiesAdverse Outcome Pathways Diseases
Pathway Ontologyaltered energy metabolic pathway
Disease OntologyParkinson's disease
- An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition. Terron A, Bal-Price A, Paini A, Monnet-Tschudi F, Bennekou SH, EFSA WG EPI1 Members, et al. Arch Toxicol. 2018 Jan;92(1):41–82. PubMed Europe PMC Scholia