G protein signaling pathways (WP1049)
Bos taurus
G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes. Source: [[wikipedia:G_protein|Wikipedia]]
Authors
Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric WeitzActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
G protein mediated signaling pathway via Galpha12/Galpha13 family G protein mediated signaling pathway G protein mediated signaling pathway via Galphas family G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galphai family| Label | Type | Compact URI | Comment |
|---|---|---|---|
| IP3 | Metabolite | hmdb:HMDB0001143 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| DAG | Metabolite | kegg.compound:C00165 | |
| cAMP | Metabolite | hmdb:HMDB0000058 | |
| PRKAR2B | GeneProduct | ensembl:ENSBTAG00000014958 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5577 |
| GNG10 | GeneProduct | ensembl:ENSBTAG00000009087 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2790 |
| PDE7B | GeneProduct | ensembl:ENSBTAG00000015888 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27115 |
| ADCY3 | GeneProduct | ensembl:ENSBTAG00000018705 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:109 |
| ADCY5 | GeneProduct | ensembl:ENSBTAG00000018777 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:111 |
| GNG12 | GeneProduct | ensembl:ENSBTAG00000035697 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55970 |
| GNG11 | GeneProduct | ensembl:ENSBTAG00000000820 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2791 |
| AKAP8 | GeneProduct | ensembl:ENSBTAG00000001807 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10270 |
| PPP3CC | GeneProduct | ensembl:ENSBTAG00000020133 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5533 |
| AKAP1 | GeneProduct | ensembl:ENSBTAG00000025320 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8165 |
| PRKAR1B | GeneProduct | ensembl:ENSBTAG00000046142 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5575 |
| GNAS | GeneProduct | ensembl:ENSBTAG00000017475 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2778 |
| PRKCD | GeneProduct | ensembl:ENSBTAG00000008719 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580 |
| GNB3 | GeneProduct | ensembl:ENSBTAG00000016043 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2784 |
| PDE4A | GeneProduct | ensembl:ENSBTAG00000012032 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5141 |
| PDE1B | GeneProduct | ensembl:ENSBTAG00000004337 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5153 |
| GNAQ | GeneProduct | ensembl:ENSBTAG00000009789 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2776 |
| GNAO1 | GeneProduct | ensembl:ENSBTAG00000003794 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2775 |
| PDE4D | GeneProduct | ensembl:ENSBTAG00000000494 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5144 |
| PRKCB | GeneProduct | ensembl:ENSBTAG00000020921 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5579 |
| RRAS | GeneProduct | ensembl:ENSBTAG00000020983 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6237 |
| GNA14 | GeneProduct | ensembl:ENSBTAG00000021127 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9630 |
| AKAP5 | GeneProduct | ensembl:ENSBTAG00000009642 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9495 |
| GNAZ | GeneProduct | ensembl:ENSBTAG00000047664 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2781 |
| ADCY4 | GeneProduct | ensembl:ENSBTAG00000018419 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:196883 |
| PDE8B | GeneProduct | ensembl:ENSBTAG00000020205 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8622 |
| NRAS | GeneProduct | ensembl:ENSBTAG00000046797 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4893 |
| GNG13 | GeneProduct | ensembl:ENSBTAG00000033526 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51764 |
| GNGT1 | GeneProduct | ensembl:ENSBTAG00000002674 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2792 |
| GNB2 | GeneProduct | ensembl:ENSBTAG00000006495 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2783 |
| PRKAR1A | GeneProduct | ensembl:ENSBTAG00000008621 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5573 |
| GNA11 | GeneProduct | ensembl:ENSBTAG00000012181 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2767 |
| PRKCH | GeneProduct | ensembl:ENSBTAG00000003276 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5583 |
| PPP3CA | GeneProduct | ensembl:ENSBTAG00000016005 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5530 |
| GNAI1 | GeneProduct | ensembl:ENSBTAG00000002714 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2770 |
| PRKACB | GeneProduct | ensembl:ENSBTAG00000011953 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5567 |
| PRKAR2A | GeneProduct | ensembl:ENSBTAG00000014205 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5576 |
| GNB5 | GeneProduct | ensembl:ENSBTAG00000003762 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10681 |
| KCNJ3 | GeneProduct | ensembl:ENSBTAG00000006159 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3760 |
| PLCB3 | GeneProduct | ensembl:ENSBTAG00000012510 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5331 |
| AKAP7 | GeneProduct | ensembl:ENSBTAG00000000240 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9465 |
| GNA13 | GeneProduct | ensembl:ENSBTAG00000046174 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10672 |
| ADCY6 | GeneProduct | ensembl:ENSBTAG00000005464 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:112 |
| AKAP3 | GeneProduct | ensembl:ENSBTAG00000001020 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10566 |
| PDE1A | GeneProduct | ensembl:ENSBTAG00000012100 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5136 |
| PDE1C | GeneProduct | ensembl:ENSBTAG00000002739 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5137 |
| ADCY2 | GeneProduct | ensembl:ENSBTAG00000019210 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:108 |
| GNAO1 | GeneProduct | ensembl:ENSBTAG00000003794 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2775 |
| GNAL | GeneProduct | ensembl:ENSBTAG00000002125 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2774 |
| PRKD1 | GeneProduct | ensembl:ENSBTAG00000012789 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5587 |
| PRKD3 | GeneProduct | ensembl:ENSBTAG00000001114 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23683 |
| ADCY9 | GeneProduct | ensembl:ENSBTAG00000016629 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:115 |
| AKAP6 | GeneProduct | ensembl:ENSBTAG00000017719 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9472 |
| ADCY1 | GeneProduct | ensembl:ENSBTAG00000009520 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:107 |
| PPP3CC | GeneProduct | ensembl:ENSBTAG00000020133 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5533 |
| AKAP13 | GeneProduct | ensembl:ENSBTAG00000037383 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11214 |
| GNA15 | GeneProduct | ensembl:ENSBTAG00000019988 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2769 |
| PDE8A | GeneProduct | ensembl:ENSBTAG00000015909 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5151 |
| AKAP12 | GeneProduct | ensembl:ENSBTAG00000014788 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9590 |
| RHOA | GeneProduct | ensembl:ENSBTAG00000004279 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387 |
| AKAP4 | GeneProduct | ensembl:ENSBTAG00000016399 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8852 |
| GNAI3 | GeneProduct | ensembl:ENSBTAG00000013016 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2773 |
| AKAP11 | GeneProduct | ensembl:ENSBTAG00000014752 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11215 |
| GNGT2 | GeneProduct | ensembl:ENSBTAG00000047325 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2793 |
| PRKCQ | GeneProduct | ensembl:ENSBTAG00000010664 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5588 |
| PDE4C | GeneProduct | ensembl:ENSBTAG00000010652 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5143 |
| GNG8 | GeneProduct | ensembl:ENSBTAG00000017762 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:94235 |
| PRKCE | GeneProduct | ensembl:ENSBTAG00000020614 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5581 |
| GNG7 | GeneProduct | ensembl:ENSBTAG00000007644 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2788 |
| PRKCG | GeneProduct | ensembl:ENSBTAG00000013550 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5582 |
| GNB1 | GeneProduct | ensembl:ENSBTAG00000000215 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2782 |
| PRKCA | GeneProduct | ensembl:ENSBTAG00000001061 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578 |
| PRKCI | GeneProduct | ensembl:ENSBTAG00000001403 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5584 |
| GNG5 | GeneProduct | ensembl:ENSBTAG00000008122 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2787 |
| GNG3 | GeneProduct | ensembl:ENSBTAG00000002508 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2785 |
| HRAS | GeneProduct | ensembl:ENSBTAG00000046644 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265 |
| PRKCZ | GeneProduct | ensembl:ENSBTAG00000014119 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5590 |
| ARHGEF1 | GeneProduct | ensembl:ENSBTAG00000018912 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9138 |
| AKAP10 | GeneProduct | ensembl:ENSBTAG00000003439 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11216 |
| GNAI1 | GeneProduct | ensembl:ENSBTAG00000002714 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2770 |
| ADCY8 | GeneProduct | ensembl:ENSBTAG00000014600 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:114 |
| ADCY7 | GeneProduct | ensembl:ENSBTAG00000006208 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:113 |
| PRKACA | GeneProduct | ensembl:ENSBTAG00000006642 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5566 |
| PDE4B | GeneProduct | ensembl:ENSBTAG00000008636 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5142 |
| PDE7A | GeneProduct | ensembl:ENSBTAG00000011614 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5150 |
| AKAP9 | GeneProduct | ensembl:ENSBTAG00000007442 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10142 |
| GNG4 | GeneProduct | ensembl:ENSBTAG00000002908 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2786 |
| GNA12 | GeneProduct | ensembl:ENSBTAG00000017871 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2768 |
| ITPR1 | GeneProduct | ensembl:ENSBTAG00000020455 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3708 |
| SLC9A1 | GeneProduct | ensembl:ENSBTAG00000008766 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6548 |
| GNAI2 | GeneProduct | ensembl:ENSBTAG00000020645 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2771 |
References
- G proteins: a family of signal transducers. Stryer L, Bourne HR. Annu Rev Cell Biol. 1986;2:391–419. PubMed Europe PMC Scholia
- G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia