ACE inhibitor pathway (WP915)

Pan troglodytes

The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (


Thomas Kelder , Egon Willighagen , Christine Chichester , Tyler Peryea , and Eric Weitz


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Pan troglodytes



Pathway Ontology

ACE inhibitor drug pathway


Label Type Compact URI Comment
Angiotensin I Metabolite pubchem.compound:3081372
ACE Inhibitor Metabolite chebi:35457
Aldosterone Metabolite kegg.compound:C01780
Bradykinin Metabolite hmdb:HMDB0004246
Angiotensin II Metabolite hmdb:HMDB0001035
AGT GeneProduct ncbigene:450104
ACE GeneProduct ncbigene:449567
KNG1 GeneProduct ncbigene:460916
AGTR1 GeneProduct ncbigene:460762
NOS3 GeneProduct ncbigene:463893
ACE GeneProduct ncbigene:449567
AGTR2 GeneProduct ncbigene:742608
REN GeneProduct ncbigene:469651
BDKRB2 GeneProduct ncbigene:467547


  1. The emerging role of ACE2 in physiology and disease. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus ADME, et al. J Pathol. 2007 May;212(1):1–11. PubMed Europe PMC Scholia