Folic acid network (WP1273)

Mus musculus

The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.


Kristina Hanspers , Samuel Sklar , Egon Willighagen , Christine Chichester , Laurent Winckers , Eric Weitz , Alex Pico , and Lars Willighagen


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Mus musculus



Pathway Ontology

folate metabolic pathway


Label Type Compact URI Comment
Zinc Metabolite hmdb:HMDB0015532
Vitamin B12 Metabolite hmdb:HMDB0000607
L-Glutamic acid Metabolite hmdb:HMDB0000148
Lipoic acid Metabolite hmdb:HMDB0001451
Homocysteine Metabolite hmdb:HMDB0000742
Cobalamin Metabolite hmdb:HMDB0002174
DHA (n-3) Metabolite hmdb:HMDB0002183
Uric acid Metabolite hmdb:HMDB0000289
Glycine Metabolite hmdb:HMDB0000123
Tryptophan Metabolite hmdb:HMDB0000929
Leukotriene B4 Metabolite hmdb:HMDB0001085
LeukotrieneE4 Metabolite hmdb:HMDB0002200
a-tocopherol Metabolite hmdb:HMDB0001893
Pyridoxal-5'-phosphate Metabolite hmdb:HMDB0001491
S-Adenosylhomocysteine Metabolite hmdb:HMDB0000939
PGG2 Metabolite hmdb:HMDB0003235
Nicotinamide Metabolite pubchem.compound:936
Glutathione Metabolite hmdb:HMDB0000125
Copper Metabolite hmdb:HMDB0000657
15-HETE Metabolite hmdb:HMDB0011134
Lipoxin A4 Metabolite hmdb:HMDB0004385
Adipic acid Metabolite hmdb:HMDB0000448
S-Adenosylmethionine Metabolite hmdb:HMDB0001185
Calcium Metabolite hmdb:HMDB0000464
Leukotriene C4 Metabolite hmdb:HMDB0001198
Manganese Metabolite hmdb:HMDB0001333
LA (n-6) Metabolite hmdb:HMDB0000673
Adipic acid Metabolite hmdb:HMDB0000448
S-Adenosylmethionine Metabolite hmdb:HMDB0001185
Choline Metabolite hmdb:HMDB0000097
Methionine sulfoxide Metabolite hmdb:HMDB0002005
Ascorbic acid Metabolite hmdb:HMDB0000044
L-Methionine Metabolite hmdb:HMDB0000696
Methylmalonic acid Metabolite hmdb:HMDB0000202
Methylmalonic acid Metabolite hmdb:HMDB0000202
Thromboxane A2 Metabolite hmdb:HMDB0001452
PGI2 Metabolite hmdb:HMDB0001335
C22:5 (n-6) Metabolite hmdb:HMDB0001976
Methionine Metabolite hmdb:HMDB0000696
Leukotriene A4 Metabolite hmdb:HMDB0001337
NADPH Metabolite hmdb:HMDB0000221
Iron Metabolite hmdb:HMDB0000692
FAD Metabolite pubchem.compound:703
Thromboxane B2 Metabolite hmdb:HMDB0003252
Leukotriene D4 Metabolite hmdb:HMDB0003080
Cysteine Metabolite hmdb:HMDB0000574
Carnitine Metabolite hmdb:HMDB0000062
Selenium Metabolite hmdb:HMDB0001349
AA (n-6) Metabolite hmdb:HMDB0001043
5-HPETE Metabolite hmdb:HMDB0001193
Riboflavin Metabolite hmdb:HMDB0000244
Betaine Metabolite hmdb:HMDB0000043
NADP Metabolite hmdb:HMDB0000217
Tromboxane A2 Metabolite hmdb:HMDB0001452
O2 Metabolite hmdb:HMDB0001377
F2-Isoprostane Metabolite hmdb:HMDB0004659
1-methylnicotinamide Metabolite hmdb:HMDB0000699
H2O Metabolite hmdb:HMDB0002111
5,10-METHYL-THF Metabolite hmdb:HMDB0001396
Ethanolamine Metabolite hmdb:HMDB0000149
PGE3 Metabolite hmdb:HMDB0002664
ALA (n-3) Metabolite hmdb:HMDB0001388
FOLIC ACID Metabolite hmdb:HMDB0000121
Heme Metabolite hmdb:HMDB0003178
iPF2-alpha Metabolite hmdb:HMDB0004659
Serine Metabolite hmdb:HMDB0000187
PGF2a Metabolite hmdb:HMDB0001139
Xanthine Metabolite hmdb:HMDB0000292
a Tocopherol Metabolite hmdb:HMDB0001893
EPA (n-3) Metabolite hmdb:HMDB0001999
1-Methylnicotinamide Metabolite hmdb:HMDB0000699
2-Ketobutyric acid Metabolite hmdb:HMDB0000005
H2O2 Metabolite hmdb:HMDB0003125
Hypoxanthine Metabolite hmdb:HMDB0000157
Lipoxin B4 Metabolite hmdb:HMDB0005082
PGD2 Metabolite hmdb:HMDB0001403
Niacin Metabolite hmdb:HMDB0001406
PGH2 Metabolite hmdb:HMDB0001381
Cystathione Metabolite hmdb:HMDB0000099
ROS Metabolite chebi:26523
Glutathione disulfide Metabolite pubchem.compound:65359
FMN1 GeneProduct ncbigene:342184
Ptges Protein ncbigene:64292
Ptgis Protein ncbigene:19223
Gpx6 Protein ncbigene:75512
Fads2 Protein ncbigene:56473
Cbs Protein ncbigene:12411
Txnrd2 Protein ncbigene:26462
Cat Protein ncbigene:12359
Mthfr Protein ncbigene:17769
Kmo Protein ncbigene:98256
Gpx2 Protein ncbigene:14776
Ptgds Protein ncbigene:19215
Selk Protein ncbigene:80795
Sepw1 Protein ncbigene:20364
Gpx3 Protein ncbigene:14778
Mtr Protein ncbigene:238505
Alox5 Protein ncbigene:11689
COX1 Protein ncbigene:3337205
Sepx1 Protein ncbigene:27361
Gsr Protein ensembl:ENSMUSG00000031584
Thioredoxin Protein ncbigene:7295
Xdh Protein ncbigene:22436
Txnrd1 Protein ncbigene:50493
Pnpo Protein ncbigene:103711
Gpx1 Protein ncbigene:14775
COX2 Protein ncbigene:3337209
Gpx4 Protein ncbigene:625249


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  22. WikiPathways: WP28