Ethanol metabolism production of ROS by CYP2E1 (WP4269)

Homo sapiens

Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes. This pathway is also available for rat and mouse.


Ado , Egon Willighagen , Marvin Martens , Friederike Ehrhart , and Eric Weitz


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Homo sapiens



Pathway Ontology


Label Type Compact URI Comment
Staurosporine Metabolite chebi:57491
Acetaldehyde Metabolite chebi:15343
Ethanol Metabolite chebi:16236
Vitamin C Metabolite chebi:38290
Diallyl sulfide Metabolite chebi:4489
U0126 Metabolite chebi:90693
Fluoride Metabolite chebi:17051
Enflurane Metabolite hmdb:HMDB0014373
Halothane Metabolite chebi:5615
Sevoflurane Metabolite chebi:9130
6-Hydroxychlorzoxazone Metabolite hmdb:HMDB0060998
Isoflurane Metabolite chebi:6015
NAPQI Metabolite chebi:29132
Methoxyflurane Metabolite chebi:6843
Acetaminophen Metabolite chebi:46195
Chlorzoxazone Metabolite chebi:3655
Trifluoroacetic acid Metabolite chebi:45892
Fluoride Metabolite chebi:17051
Fluoride Metabolite chebi:17051
MAPK8 GeneProduct ensembl:ENSG00000107643
CYP2E1 GeneProduct ensembl:ENSG00000130649
CYP2E1 GeneProduct ensembl:ENSG00000130649
SP1 GeneProduct ensembl:ENSG00000185591
MAP2K2 GeneProduct ensembl:ENSG00000126934
MAFF GeneProduct ensembl:ENSG00000185022
MAFG GeneProduct ensembl:ENSG00000197063
MAP2K1 GeneProduct ensembl:ENSG00000169032
MAFK GeneProduct ensembl:ENSG00000198517
NFE2L2 GeneProduct ensembl:ENSG00000116044
SP1 GeneProduct ensembl:ENSG00000185591
CYP2E1 GeneProduct ensembl:ENSG00000130649
NFE2L2 GeneProduct ensembl:ENSG00000116044
Protein kinase C Protein uniprot:A0A087X0I9


  1. Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Jin M, Ande A, Kumar A, Kumar S. Cell Death Dis. 2013 Mar 21;4(3):e554. PubMed Europe PMC Scholia