TSLP signaling pathway (WP3191)
Bos taurus
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine involved in regulation of a broad spectrum of biological processes. The TSLP receptor complex consists of the IL-7 receptor alpha subunit and its unique TSLPR subunit (gene symbol CRLF2). TSLP can be secreted by epithelial cells upon pathogen stimulation. TSLP can also activate dendritic cells, CD4+ T cells and CD8+ T cells. TSLP not only activate the JAK/STAT pathway but also induce phosphorylation of other signaling molecules including PI3K/Akt, ERK1/2 and JNKs. Aberrant TSLP signaling is implicated in a number of the development of diseases, including asthma, atopic dermatitis, eosinophilic eosophagitis and acute lymphoid leukemia. Description source: [http://www.netpath.org/pathways?path_id=NetPath_24 NetPath]
Authors
Martina Summer-Kutmon , Egon Willighagen , Kristina Hanspers , and Eric WeitzActivity
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
interleukin-2 family mediated signaling pathway cytokine mediated signaling pathway Jak-Stat signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| MAP2K2 | Protein | ensembl:ENSBTAG00000024450 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605 |
| MAPK3 | Protein | ensembl:ENSBTAG00000016156 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595 |
| CRLF2 | Protein | ensembl:ENSBTAG00000020242 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64109 |
| STAT1 | Protein | ensembl:ENSBTAG00000007867 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772 |
| STAT3 | Protein | ensembl:ENSBTAG00000021523 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774 |
| STAT4 | Protein | ensembl:ENSBTAG00000046699 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6775 |
| PIK3CA | Protein | ensembl:ENSBTAG00000009232 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290 |
| AKT1 | Protein | ensembl:ENSBTAG00000017636 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207 |
| MAPK1 | Protein | ensembl:ENSBTAG00000010312 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594 |
| MTOR | Protein | ensembl:ENSBTAG00000015325 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475 |
| RPS6 | Protein | ensembl:ENSBTAG00000014449 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194 |
| PTPN11 | Protein | ensembl:ENSBTAG00000002048 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781 |
| JAK2 | Protein | ensembl:ENSBTAG00000012047 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717 |
| JAK1 | Protein | ensembl:ENSBTAG00000003147 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716 |
| IL7R | Protein | ensembl:ENSBTAG00000019975 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3575 |
| MAP2K1 | Protein | ensembl:ENSBTAG00000033983 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604 |
| MAPK14 | Protein | ensembl:ENSBTAG00000020783 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432 |
| EIF4EBP1 | Protein | ensembl:ENSBTAG00000027654 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1978 |
| BIKBA | Protein | ensembl:ENSBTAG00000016683 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4792 |
| RELB | Protein | ensembl:ENSBTAG00000038428 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5971 |
| RELA | Protein | ensembl:ENSBTAG00000013895 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970 |
| NFKB1 | Protein | ensembl:ENSBTAG00000020270 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790 |
| NFKB2 | Protein | ensembl:ENSBTAG00000006017 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4791 |
| MAPK8 | Protein | ensembl:ENSBTAG00000007876 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599 |
| RELA | Protein | ensembl:ENSBTAG00000013895 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970 |
| RELB | Protein | ensembl:ENSBTAG00000038428 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5971 |
| NFKB1 | Protein | ensembl:ENSBTAG00000020270 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790 |
| NFKB2 | Protein | ensembl:ENSBTAG00000006017 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4791 |
| TEC | Protein | ensembl:ENSBTAG00000005062 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7006 |
| PI4K2A | Protein | ensembl:ENSBTAG00000002010 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55361 |
| RPS6 | Protein | ensembl:ENSBTAG00000014449 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194 |
| EIF4EBP1 | Protein | ensembl:ENSBTAG00000027654 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1978 |
| AKT1 | Protein | ensembl:ENSBTAG00000017636 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207 |
| STAT6 | Protein | ensembl:ENSBTAG00000006335 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6778 |
| SRC | Protein | ensembl:ENSBTAG00000008938 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714 |
| STAT5B | Protein | ensembl:ENSBTAG00000010125 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777 |
| STAT5A | Protein | ensembl:ENSBTAG00000009496 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776 |
| STAT5B | Protein | ensembl:ENSBTAG00000010125 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777 |
| STAT5A | Protein | ensembl:ENSBTAG00000009496 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776 |
| STAT3 | Protein | ensembl:ENSBTAG00000021523 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774 |
| MAPK9 | Protein | ensembl:ENSBTAG00000004709 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601 |
| YES1 | Protein | ensembl:ENSBTAG00000001523 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7525 |
| LCK | Protein | ensembl:ENSBTAG00000012695 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3932 |
| BTK | Protein | ensembl:ENSBTAG00000019250 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:695 |
| FES | Protein | ensembl:ENSBTAG00000002941 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2242 |
| HCK | Protein | ensembl:ENSBTAG00000007932 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3055 |
| FYN | Protein | ensembl:ENSBTAG00000011851 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534 |
| LYN | Protein | ensembl:ENSBTAG00000020034 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4067 |