Hepatocyte growth factor receptor signaling (WP927)

Pan troglodytes

Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.


Linda Rieswijk , Eric Weitz , and Denise Slenter


last edited

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Pan troglodytes



Pathway Ontology

scatter factor/hepatocyte growth factor signaling pathway Rho/Rac/Cdc42 mediated signaling pathway

Cell Type Ontology



Label Type Compact URI Comment
RAPGEF1 GeneProduct ncbigene:464812
RAF1 GeneProduct ncbigene:460182
RAP1B GeneProduct ncbigene:452065
SRC GeneProduct ncbigene:458229
PTK2 GeneProduct ncbigene:464422
CRK GeneProduct ncbigene:747142
PTK2B GeneProduct ncbigene:464073
PXN GeneProduct ncbigene:452303
GAB1 GeneProduct ncbigene:461516
PTEN GeneProduct ncbigene:466142
HGF GeneProduct ncbigene:463503
MAP2K2 GeneProduct ncbigene:456390
RASA1 GeneProduct ncbigene:461762
PTK2B GeneProduct ncbigene:464073
MAP4K1 GeneProduct ncbigene:748652
Met GeneProduct ncbigene:463671
MAP2K1 GeneProduct ncbigene:450188
SRC GeneProduct ncbigene:458229
ITGA1 GeneProduct ncbigene:461880
RAP1A GeneProduct ncbigene:469408
MAPK1 GeneProduct ncbigene:458680
PAK1 GeneProduct ncbigene:451439
MAPK8 GeneProduct ncbigene:450445
PIK3CA GeneProduct ncbigene:460858
CRKL GeneProduct ncbigene:470146
STAT3 GeneProduct ncbigene:454682
HRAS GeneProduct ncbigene:466302
SOS1 GeneProduct ncbigene:459171 Son of sevenless homolog 1 (Drosophila) (predicted)
JUN GeneProduct ncbigene:456893
PTK2 GeneProduct ncbigene:464422
GRB2 GeneProduct ncbigene:737245
ITGB1 GeneProduct ncbigene:450396
DOCK1 GeneProduct ncbigene:739420 Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
PTPN11 GeneProduct ncbigene:748225
PXN GeneProduct ncbigene:452303
MAPK3 GeneProduct ncbigene:454037
FOS GeneProduct ncbigene:453047


  1. An overview of the c-MET signaling pathway. Organ SL, Tsao MS. Ther Adv Med Oncol. 2011 Nov;3(1 Suppl):S7–19. PubMed Europe PMC Scholia