EGFR1 signaling pathway (WP1096)

Canis familiaris

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The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Authors

Michiel Adriaens , Alex Pico , Christine Chichester , and Eric Weitz

Activity

last edited

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Organisms

Canis familiaris

Communities

Annotations

Pathway Ontology

epidermal growth factor/neuregulin signaling pathway

Participants

Label Type Compact URI Comment
EGF GeneProduct ncbigene:403657
RAF1 GeneProduct ncbigene:484648
NRAS GeneProduct ncbigene:403872
HRAS GeneProduct ncbigene:403735
SHOC2 GeneProduct ncbigene:477819
PIK3R1 GeneProduct ncbigene:487235
MAP3K2 GeneProduct ncbigene:612902
GRB14 GeneProduct ncbigene:478770
GRB2 GeneProduct ncbigene:483312
MAP3K3 GeneProduct ncbigene:480481
SOS1 GeneProduct ncbigene:483042
GRB7 GeneProduct ncbigene:491021
PIK3R2 GeneProduct ncbigene:609956
SHC1 GeneProduct ncbigene:490439
PIK3R3 GeneProduct ncbigene:482512
PIK3CA GeneProduct ncbigene:488084
PIK3CB GeneProduct ncbigene:477085
PIK3CD GeneProduct ncbigene:489644
PIK3CG GeneProduct ncbigene:483266
GAB1 GeneProduct ncbigene:483808
GAB2 GeneProduct ncbigene:485167
JAK1 GeneProduct ncbigene:442952
STAT1 GeneProduct ncbigene:488449
JAK2 GeneProduct ncbigene:484185
STAT3 GeneProduct ncbigene:490967
STAT5A GeneProduct ncbigene:490968
STAT2 GeneProduct ncbigene:481111
STAT5B GeneProduct ncbigene:490969
MAP2K1 GeneProduct ncbigene:478347
PRKCA GeneProduct ncbigene:490904
MAP3K1 GeneProduct ncbigene:478061
PRKCZ GeneProduct ncbigene:479577
PRKD1 GeneProduct ncbigene:609091
PRKCI GeneProduct ncbigene:478686
PRKCB GeneProduct ncbigene:489968
PRKCG GeneProduct ncbigene:484316
MAP2K2 GeneProduct ncbigene:611939
MAP2K3 GeneProduct ncbigene:489547
MAP3K4 GeneProduct ncbigene:476262
VAV1 GeneProduct ncbigene:485016
VAV3 GeneProduct ncbigene:479921
VAV2 GeneProduct ncbigene:608060
MAPK7 GeneProduct ncbigene:489532
MAPK1 GeneProduct ncbigene:477575
MAPK3 GeneProduct ncbigene:486758
ELK4 GeneProduct ncbigene:488574
ELK1 GeneProduct ncbigene:491860
MAPK8 GeneProduct ncbigene:477746
MAP2K7 GeneProduct ncbigene:485004
PTPRR GeneProduct ncbigene:481163
GJA1 GeneProduct ncbigene:403418
YWHAB GeneProduct ncbigene:477237
WNK1 GeneProduct ncbigene:477728
EGFR GeneProduct ncbigene:404306
KRT7 GeneProduct ncbigene:477602
KRT8 GeneProduct ncbigene:486513
KRT17 GeneProduct ncbigene:490977
KRT18 GeneProduct ncbigene:477601
EPPK1 GeneProduct ncbigene:475117
PLEC1 GeneProduct ncbigene:482083
PTPN12 GeneProduct ncbigene:483277
STAT3 GeneProduct ncbigene:490967
PLSCR1 GeneProduct ncbigene:611500
ERRFI1 GeneProduct ncbigene:489636
DOK2 GeneProduct ncbigene:486133
PITPNA GeneProduct ncbigene:480648
CBLC GeneProduct ncbigene:612343
CBLB GeneProduct ncbigene:487965
PLD2 GeneProduct ncbigene:479473
PLD1 GeneProduct ncbigene:488167
PRKCA GeneProduct ncbigene:490904
EPS15 GeneProduct ncbigene:475356
EPS8 GeneProduct ncbigene:477686
HTT GeneProduct ncbigene:479074
PIK3C2B GeneProduct ncbigene:478938
SH3BGRL GeneProduct ncbigene:491986
CSK GeneProduct ncbigene:487649
REPS2 GeneProduct ncbigene:491756
RALBP1 GeneProduct ncbigene:490548
RALB GeneProduct ncbigene:483881
REPS1 GeneProduct ncbigene:476221
TNK2 GeneProduct ncbigene:488025
ABI1 GeneProduct ncbigene:607247
SOS2 GeneProduct ncbigene:490682
DNM1 GeneProduct ncbigene:491319
SH3GL3 GeneProduct ncbigene:609858
CDC42 GeneProduct ncbigene:607535
SPRY2 GeneProduct ncbigene:485504
JUND GeneProduct ncbigene:609409
FOS GeneProduct ncbigene:490792
MYC GeneProduct ncbigene:403924
PEBP1 GeneProduct ncbigene:477501
KLF11 GeneProduct ncbigene:475665
SIN3A GeneProduct ncbigene:478372
LOC487309 GeneProduct ncbigene:487309
SH3KBP1 GeneProduct ncbigene:612797
SH3GL2 GeneProduct ncbigene:611239
JUN GeneProduct ncbigene:609429
SP1 GeneProduct ncbigene:486507
AKT1 GeneProduct ncbigene:490878
PTPN5 GeneProduct ncbigene:485409
SNCA GeneProduct ncbigene:478478
RPS6KA1 GeneProduct ncbigene:487353
RPS6KA3 GeneProduct ncbigene:491768
RPS6KA2 GeneProduct ncbigene:612448
AP2A1 GeneProduct ncbigene:484375
WASL GeneProduct ncbigene:475213
CEACAM1 GeneProduct ncbigene:612435
EEF1A2 GeneProduct ncbigene:403506
APPL1 GeneProduct ncbigene:484716
APPL2 GeneProduct ncbigene:481297
MTA2 GeneProduct ncbigene:476057
EPS15L1 GeneProduct ncbigene:484849
EPN1 GeneProduct ncbigene:608964
HIP1 GeneProduct ncbigene:489814
RFXANK GeneProduct ncbigene:476662
MAPK14 GeneProduct ncbigene:403856
TNIP1 GeneProduct ncbigene:489178
EGFR GeneProduct ncbigene:404306
EGFR GeneProduct ncbigene:404306
RBBP7 GeneProduct ncbigene:480854
ASAP1 GeneProduct ncbigene:482044
CTNND1 GeneProduct ncbigene:483489
PKN2 GeneProduct ncbigene:490174
PAK1 GeneProduct ncbigene:607885
SH2D3C GeneProduct ncbigene:491326
BCAR1 GeneProduct ncbigene:479648
CASP9 GeneProduct ncbigene:487432
RPS6KA5 GeneProduct ncbigene:490831
SMAD2 GeneProduct ncbigene:480144
SMAD3 GeneProduct ncbigene:610902
SMAD2 GeneProduct ncbigene:480144
SMAD3 GeneProduct ncbigene:610902
ATF1 GeneProduct ncbigene:486545
CREB1 GeneProduct ncbigene:607922
FOXO1 GeneProduct ncbigene:477295
PXN GeneProduct ncbigene:486299
ELF3 GeneProduct ncbigene:490235
LOC478799 GeneProduct ncbigene:478799
CAMK2A GeneProduct ncbigene:612941
ITCH GeneProduct ncbigene:477199
ARAF GeneProduct ncbigene:491857
MCF2 GeneProduct ncbigene:492176
ELF3 GeneProduct ncbigene:490235
RPS6KA3 GeneProduct ncbigene:491768
MAP3K2 GeneProduct ncbigene:612902
FOXO1 GeneProduct ncbigene:477295
EPS15 GeneProduct ncbigene:475356
EEF1A2 GeneProduct ncbigene:403506
STAT1 GeneProduct ncbigene:488449
STAT3 GeneProduct ncbigene:490967
STAT2 GeneProduct ncbigene:481111
STAT5A GeneProduct ncbigene:490968
ZNF259 GeneProduct ncbigene:479428
PLCG1 GeneProduct ncbigene:485874
SPRY2 GeneProduct ncbigene:485504
PLCG2 GeneProduct ncbigene:489692
PLCG2 GeneProduct ncbigene:489692
PTPN6 GeneProduct ncbigene:486717
RAF1 GeneProduct ncbigene:484648
GAB1 GeneProduct ncbigene:483808
SHC1 GeneProduct ncbigene:490439
PLD1 GeneProduct ncbigene:488167
BCAR1 GeneProduct ncbigene:479648
SH2D3C GeneProduct ncbigene:491326
APPL1 GeneProduct ncbigene:484716
APPL1 GeneProduct ncbigene:484716
APPL2 GeneProduct ncbigene:481297
STAT1 GeneProduct ncbigene:488449
SRC GeneProduct ncbigene:485864
CRKL GeneProduct ncbigene:608125
NDUFA13 GeneProduct ncbigene:476659
RAC1 GeneProduct ncbigene:403955
PTK2B GeneProduct ncbigene:486102
CAV1 GeneProduct ncbigene:403980
CAV2 GeneProduct ncbigene:475294
NCK1 GeneProduct ncbigene:485677
NCK2 GeneProduct ncbigene:481319
PLCG1 GeneProduct ncbigene:485874
GIT1 GeneProduct ncbigene:491180
RGS8 GeneProduct ncbigene:490311
SOCS1 GeneProduct ncbigene:490006
SOCS3 GeneProduct ncbigene:442949
INPPL1 GeneProduct ncbigene:485209
RAB5A GeneProduct ncbigene:404008
USP6NL GeneProduct ncbigene:487132
ARF4 GeneProduct ncbigene:607073
ZNF259 GeneProduct ncbigene:479428
RIPK1 GeneProduct ncbigene:488195
MAP3K14 GeneProduct ncbigene:490926
RALGDS GeneProduct ncbigene:480686
RASA1 GeneProduct ncbigene:479158
PRKAR1A GeneProduct ncbigene:480459
PTPN6 GeneProduct ncbigene:486717
PTPN11 GeneProduct ncbigene:477488
MAPK1 GeneProduct ncbigene:477575
MAP2K1 GeneProduct ncbigene:478347
DUSP1 GeneProduct ncbigene:489117
DUSP1 GeneProduct ncbigene:489117
ARF4 GeneProduct ncbigene:607073
ARF4 GeneProduct ncbigene:607073
EGF GeneProduct ncbigene:403657
EGF GeneProduct ncbigene:403657
SH3GL2 GeneProduct ncbigene:611239
EGFR GeneProduct ncbigene:404306

References

  1. Control of MAPK signalling: from complexity to what really matters. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV. Oncogene. 2005 Aug 25;24(36):5533–42. PubMed Europe PMC Scholia