Deregulation of renin-angiotensin system by SARS-CoV infection (WP4965)

Mus musculus

The spike protein of SARS-CoV down regulates ACE2, leading to deregulation of the renin-angiotensin system. This deregulation can be the cause of lung injury that is linked to SARS-CoV infection. This work was done in a mouse model.


Jordi Doijen , Egon Willighagen , Denise Slenter , Eric Weitz , and Martina Summer-Kutmon


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Mus musculus




Cell Type Ontology

native cell

Disease Ontology

viral infectious disease

Pathway Ontology

G protein mediated signaling pathway


Label Type Compact URI Comment
Angiotensin II Metabolite hmdb:HMDB0001035
Angiotensin I Metabolite hmdb:HMDB0061196
Angiotensin-(1-7) Metabolite chebi:55438
Angiotensinogen Metabolite chebi:2720
Angiotensin-(1-9) Metabolite chebi:80128
Agtr1a GeneProduct ensembl:ENSMUSG00000049115
Ace2 GeneProduct ensembl:ENSMUSG00000015405
Ace GeneProduct ensembl:ENSMUSG00000020681
Agtr2 GeneProduct ensembl:ENSMUSG00000068122


  1. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, et al. Nat Med. 2005 Aug;11(8):875–9. PubMed Europe PMC Scholia