IGF-1 signaling (WP2892)

Bos taurus

The activated IGF-1R (Insulin-like growth factor 1 receptor) regulates cellular adhesion, cytoskeletal organization and migration through interaction with adhesion molecules and integrin. In normal physiology the IGF-1R stimulates linear body growth, promotes neuronal survival and myelination, postnatal mammary gland development and lactation and is implicated in bone formation and renal function (Fortes et al,2013).


Zahra Roudbari , Martina Summer-Kutmon , Chris Evelo , Egon Willighagen , Kristina Hanspers , Jonathan Mélius , and Eric Weitz


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Bos taurus



Pathway Ontology

signaling pathway


Label Type Compact URI Comment
IGF1 GeneProduct ncbigene:281239
IGF1R GeneProduct ncbigene:281848
SHC2 GeneProduct ensembl:ENSBTAG00000016072
SHC1 GeneProduct ncbigene:507196
SHC3 GeneProduct ncbigene:512696
SHC4 GeneProduct ncbigene:524734
MAPK1 GeneProduct ensembl:ENSBTAG00000010312
MAPK3 GeneProduct ncbigene:531391
MAPK4 GeneProduct ensembl:ENSBTAG00000009907
MAPK6 GeneProduct ncbigene:538094
MAPK7 GeneProduct ncbigene:537703
MAPK8 GeneProduct ensembl:ENSBTAG00000007876
MAPK9 GeneProduct ncbigene:534125
MAPK10 GeneProduct ncbigene:537631
MAPK11 GeneProduct ncbigene:618906
MAPK12 GeneProduct ncbigene:512943
MAPK13 GeneProduct ncbigene:535327
MAPK14 GeneProduct ncbigene:534492
MAPK15 GeneProduct ncbigene:512125
IRS1 GeneProduct ensembl:ENSBTAG00000021308
IRS2 GeneProduct ensembl:ENSBTAG00000012019
AKT1 GeneProduct ensembl:ENSBTAG00000017636
AKT2 GeneProduct ncbigene:534923
AKT3 GeneProduct ncbigene:100137872
MTOR GeneProduct ncbigene:100139219
BAD GeneProduct ncbigene:615013
NRAS GeneProduct ncbigene:506322
HRAS GeneProduct ncbigene:100298939
KRAS GeneProduct ncbigene:541140
ARAF GeneProduct ncbigene:540421
BRAF GeneProduct ensembl:ENSBTAG00000021761
RAF1 GeneProduct ncbigene:521196


  1. Insulin-like growth factors and their binding proteins: biological actions. Jones JI, Clemmons DR. Endocr Rev. 1995 Feb;16(1):3–34. PubMed Europe PMC Scholia
  2. The IGF1 pathway genes and their association with age of puberty in cattle. Fortes MRS, Li Y, Collis E, Zhang Y, Hawken RJ. Anim Genet. 2013 Feb;44(1):91–5. PubMed Europe PMC Scholia