The activated IGF-1R (Insulin-like growth factor 1 receptor) regulates cellular adhesion, cytoskeletal organization and migration through interaction with adhesion molecules and integrin. In normal physiology the IGF-1R stimulates linear body growth, promotes neuronal survival and myelination, postnatal mammary gland development and lactation and is implicated in bone formation and renal function (Fortes et al,2013).
dc6
fc5
signaling pathway
PW:0000003
Pathway Ontology
22554198
PubMed
The IGF1 pathway genes and their association with age of puberty in cattle.
Anim Genet
2013
Fortes MR
Li Y
Collis E
Zhang Y
Hawken RJ
7758431
PubMed
Insulin-like growth factors and their binding proteins: biological actions.
Endocr Rev
1995
Jones JI
Clemmons DR