IL-10 anti-inflammatory signaling pathway (WP4495)

Homo sapiens

IL-10 binds to its respective IL-10 receptor which activates the JAK/STAT pathway and MAPK pathway involving the p38 kinases. This leads to the induction of the enzyme heme oxygenase-1 (HMOX1) which is involved in the biosynthesis of heme, and catalyzes the reaction producing the heme precursor biliverdin. The ani-inflammatory actions of HMOX appear to be the result of signaling by carbon monoxide which inhibits pro-inflammatory cytokine production.


Laurent Winckers , Friederike Ehrhart , Eric Weitz , Egon Willighagen , Alex Pico , and Denise Slenter


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Homo sapiens



Pathway Ontology

Interleukin-10 signaling pathway signaling pathway

Cell Type Ontology



Label Type Compact URI Comment
Bilirubin Metabolite wikidata:Q104219
Heme Metabolite wikidata:Q189621
Biliverdin Metabolite wikidata:Q422964
CO Metabolite wikidata:Q2025
BLVRA GeneProduct ncbigene:644
BLVRB GeneProduct ncbigene:645
IL10RA GeneProduct ncbigene:3587
IL10RB GeneProduct ncbigene:3588
IL1A GeneProduct ncbigene:3552
IL6 GeneProduct ncbigene:3569
JAK1 GeneProduct ncbigene:3716
STAT1 GeneProduct ncbigene:6772
STAT2 GeneProduct ncbigene:6773
STAT3 GeneProduct ncbigene:6774
TNF GeneProduct ncbigene:7214
IL10 GeneProduct ncbigene:3586
HMOX1 GeneProduct ncbigene:3162
HMOX1 GeneProduct ncbigene:3162


  1. The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges. Hutchins AP, Diez D, Miranda-Saavedra D. Brief Funct Genomics. 2013 Nov;12(6):489–98. PubMed Europe PMC Scholia
  2. A network map of Interleukin-10 signaling pathway. Verma R, Balakrishnan L, Sharma K, Khan AA, Advani J, Gowda H, et al. J Cell Commun Signal. 2016 Mar;10(1):61–7. PubMed Europe PMC Scholia