Differentiation of white and brown adipocyte (WP2895)

Homo sapiens

Development of white versus brown adipocytes (figure from Handbook of Obesity). Transcription factors and nuclear regulators controlling the development of white versus brown adipocytes are shown in the pathway. At the bottom a selection of identified markers of white and brown adipocytes were added (from Nascimento et al).


Martina Summer-Kutmon , Egon Willighagen , Susan Coort , Eric Weitz , and Marvin Martens


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Homo sapiens



Pathway Ontology

regulatory pathway


Label Type Compact URI Comment
Leptin GeneProduct ensembl:ENSG00000174697
Adiponectin GeneProduct ensembl:ENSG00000181092
ASC-1 GeneProduct ensembl:ENSG00000130876
HOXC8 GeneProduct ensembl:ENSG00000037965
HOXC9 GeneProduct ensembl:ENSG00000180806
PRDM16 GeneProduct ensembl:ENSG00000142611
CIDEA GeneProduct ensembl:ENSG00000176194
EBF3 GeneProduct ensembl:ENSG00000108001
HSPB7 GeneProduct ensembl:ENSG00000173641
ZIC1 GeneProduct ensembl:ENSG00000152977
EVA1 GeneProduct ensembl:ENSG00000149573
BMP2 GeneProduct ensembl:ENSG00000125845
BMP4 GeneProduct ensembl:ENSG00000125378
Smad1 GeneProduct ensembl:ENSG00000170365
Smad5 GeneProduct ensembl:ENSG00000113658
Smad8 GeneProduct ensembl:ENSG00000120693
C/EBPβ GeneProduct ensembl:ENSG00000172216
C/EBPδ GeneProduct ensembl:ENSG00000153879
PRDM16 GeneProduct ensembl:ENSG00000142611
Zfp423 GeneProduct ensembl:ENSG00000102935
PPARγ GeneProduct ensembl:ENSG00000132170
C/EBPα GeneProduct ensembl:ENSG00000245848
BMP7 GeneProduct ensembl:ENSG00000101144
Smad9 GeneProduct ensembl:ENSG00000120693
PLAC8 GeneProduct ensembl:ENSG00000145287
PRDM16 GeneProduct ensembl:ENSG00000142611
PGC-1α GeneProduct ensembl:ENSG00000109819
PGC-1β GeneProduct ensembl:ENSG00000155846
Smad5 GeneProduct ensembl:ENSG00000113658
Smad1 GeneProduct ensembl:ENSG00000170365
C/EBPβ GeneProduct ensembl:ENSG00000172216


  1. Handbook of Obesity -- Volume 1 [Internet]. Bray GA. 2014. 0 p. Available from: https://books.google.com/books/about/Handbook_of_Obesity_Volume_1.html?hl=&id=2ELdwAEACAAJ OpenLibrary Worldcat
  2. Fat cells gain new identities. Nascimento EBM, Boon MR, van Marken Lichtenbelt WD. Sci Transl Med. 2014 Jul 30;6(247):247fs29. PubMed Europe PMC Scholia