Differentiation pathway (WP3223)

Bos taurus

This pathway provides an overview of the directed differentiation molecules used to induce early and derivative cell lineages from human pluripotent stem cells. The initial version of this pathway is a direct adaptation of the SnapShot "Directed Differentiation of Pluripotent Stem Cells" pathway authored by Luis A. Williams, Brandi N. Davis-Dusenbery, and Kevin C. Eggan, HHMI, Harvard University, Cell 149, May 25, 2012 Elsevier Inc. DOI 10.1016/j.cell.2012.05.015. http://download.cell.com/pdf/PIIS0092867412005946.pdf. This adaptation was generated by Meenakshi Venkatasubramanian and Krithika Ramasamy Subramanian at Cincinnati Children's Hospital in the laboratory of Nathan Salomonis.

Authors

Martina Summer-Kutmon , Susan Coort , Egon Willighagen , and Eric Weitz

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

regulatory pathway

Disease Ontology

spinal cord disease post-traumatic stress disorder

Cell Type Ontology

stem cell astrocyte of the spinal cord

Participants

Label Type Compact URI Comment
Ascorbic acid Metabolite hmdb:HMDB0000044
A-83-01 Metabolite pubchem.compound:16218924
Selenium Metabolite hmdb:HMDB0001349
Retinoic acid Metabolite hmdb:HMDB0001852
Niacinamide Metabolite hmdb:HMDB0001406
SB431542 Metabolite pubchem.compound:4521392 http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4521392
Cyclopamine Metabolite pubchem.compound:442972
DAPT Metabolite pubchem.compound:5311272 http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5311272&loc=ec_rcs
Beta-Glycerophosphoric acid Metabolite hmdb:HMDB0002520
Dexamethasone Metabolite hmdb:HMDB0015364
Taurine Metabolite hmdb:HMDB0000251
Vitamin A Metabolite hmdb:HMDB0000305
Naltrexone Metabolite hmdb:HMDB0014842
NT5E GeneProduct ensembl:ENSBTAG00000045976 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135318
INHBA GeneProduct ensembl:ENSBTAG00000002912 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3624
FGF2 GeneProduct ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685
CXCR2 GeneProduct ensembl:ENSBTAG00000026753 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163464
SHH GeneProduct ensembl:ENSBTAG00000024552 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164690
BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378
TGFB1 GeneProduct ensembl:ENSBTAG00000020457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
NOG GeneProduct ensembl:ENSBTAG00000040282 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183691
KIT GeneProduct ensembl:ENSBTAG00000002699 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157404
VEGFA GeneProduct ensembl:ENSBTAG00000047561 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112715
FGF4 GeneProduct ensembl:ENSBTAG00000012563 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000075388
IGF-I GeneProduct ensembl:ENSBTAG00000011082 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000017427
HGF GeneProduct ensembl:ENSBTAG00000017664 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000019991
NOTCH1 GeneProduct ensembl:ENSBTAG00000022799 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4851
WNT3A GeneProduct ensembl:ENSBTAG00000039397 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154342
NODAL GeneProduct ensembl:ENSBTAG00000013090 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000156574
KITLG GeneProduct ensembl:ENSBTAG00000017549 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000049130
FLT3LG GeneProduct ensembl:ENSBTAG00000038045 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000090554
CSF1 GeneProduct ensembl:ENSBTAG00000000283 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184371
IL6 GeneProduct ensembl:ENSBTAG00000014921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244
EPO GeneProduct ensembl:ENSBTAG00000003430 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130427
INHBA GeneProduct ensembl:ENSBTAG00000002912 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122641
PDGFB GeneProduct ensembl:ENSBTAG00000021697 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100311
IL11 GeneProduct ensembl:ENSBTAG00000047400 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000095752
DKK1 GeneProduct ensembl:ENSBTAG00000014218 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107984
WNT1 GeneProduct ensembl:ENSBTAG00000015364 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125084
TGFB3 GeneProduct ensembl:ENSBTAG00000012004 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119699
NTF4 GeneProduct ensembl:ENSBTAG00000047078 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000225950
FST GeneProduct ensembl:ENSBTAG00000003329 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134363
GDF5 GeneProduct ensembl:ENSBTAG00000004429 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125965
TF GeneProduct ensembl:ENSBTAG00000007273 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091513
CSF1R GeneProduct ensembl:ENSBTAG00000012771 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182578
TNFSF11 GeneProduct ensembl:ENSBTAG00000008924 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120659
WNT2B GeneProduct ensembl:ENSBTAG00000014291 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7482
WNT5A GeneProduct ensembl:ENSBTAG00000020221 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7474
WNT7B GeneProduct ensembl:ENSBTAG00000009532 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7477
WNT2 GeneProduct ensembl:ENSBTAG00000008097 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7472
IL6R GeneProduct ensembl:ENSBTAG00000018474 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160712
FGF8 GeneProduct ensembl:ENSBTAG00000001530 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107831
ALK GeneProduct ensembl:ENSBTAG00000007379 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171094
LEFTY1 GeneProduct ensembl:ENSBTAG00000002855 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000243709
CNTF GeneProduct ensembl:ENSBTAG00000003624 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000242689
PDGFA GeneProduct ensembl:ENSBTAG00000014541 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197461
FGF1 GeneProduct ensembl:ENSBTAG00000005198 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113578
BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:652

References

  1. Repertoire of microglial and macrophage responses after spinal cord injury. David S, Kroner A. Nat Rev Neurosci. 2011 Jun 15;12(7):388–99. PubMed Europe PMC Scholia
  2. Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development. Poulain M, Ober EA. Development. 2011 Aug;138(16):3557–68. PubMed Europe PMC Scholia
  3. Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells. Chou ST, Byrska-Bishop M, Tober JM, Yao Y, Vandorn D, Opalinska JB, et al. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17573–8. PubMed Europe PMC Scholia