PI3K-Akt signaling pathway (WP4172)

Homo sapiens

Authors

Kristina Hanspers , Anders Riutta , Egon Willighagen , and Eric Weitz

Activity

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Cited In

• A Novel Based-Network Strategy to Identify Phytochemicals from Radix Salviae Miltiorrhizae (Danshen) for Treating Alzheimer’s Disease (2022).
• Tumour Stem Cells in Breast Cancer (2022).
• Transcriptome Signature of Immune Cells Post Reovirus Treatment in KRAS Mutated Colorectal Cancer (2021).
• Assessing the Contribution of Relative Macrophage Frequencies to Subcutaneous Adipose Tissue (2021).
• Predictive models for stage and risk classification in head and neck squamous cell carcinoma (HNSCC) (2020).

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

cancer

Pathway Ontology

signaling pathway cell adhesion signaling pathway phosphatidylinositol 3-kinase signaling pathway phosphatidylinositol 3-kinase signaling pathway mTOR signaling pathway signaling pathway cancer pathway cell cycle pathway mTOR signaling pathway

References

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2. Structure and function of phosphoinositide 3-kinases. Wymann MP, Pirola L. Biochim Biophys Acta. 1998 Dec 8;1436(1–2):127–50. PubMed Europe PMC Scholia
3. Oncogenic kinase signalling. Blume-Jensen P, Hunter T. Nature. 2001 May 17;411(6835):355–65. PubMed Europe PMC Scholia
4. Regulation of Raf-Akt Cross-talk. Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M. J Biol Chem. 2002 Aug 23;277(34):31099–106. PubMed Europe PMC Scholia
5. Activation of the PI3K/Akt pathway and chemotherapeutic resistance. West KA, Castillo SS, Dennis PA. Drug Resist Updat. 2002 Dec;5(6):234–48. PubMed Europe PMC Scholia
6. The role of PI3K in immune cells. Koyasu S. Nat Immunol. 2003 Apr;4(4):313–9. PubMed Europe PMC Scholia
7. PI3K in lymphocyte development, differentiation and activation. Okkenhaug K, Vanhaesebroeck B. Nat Rev Immunol. 2003 Apr;3(4):317–30. PubMed Europe PMC Scholia
8. PI3-kinase and TOR: PIKTORing cell growth. Richardson CJ, Schalm SS, Blenis J. Semin Cell Dev Biol. 2004 Apr;15(2):147–59. PubMed Europe PMC Scholia
9. PI3K-Akt pathway: its functions and alterations in human cancer. Osaki M, Oshimura M, Ito H. Apoptosis. 2004 Nov;9(6):667–76. PubMed Europe PMC Scholia
10. The activation of Akt/PKB signaling pathway and cell survival. Song G, Ouyang G, Bao S. J Cell Mol Med. 2005;9(1):59–71. PubMed Europe PMC Scholia
11. “New”-clear functions of PDK1: beyond a master kinase in the cytosol? Kikani CK, Dong LQ, Liu F. J Cell Biochem. 2005 Dec 15;96(6):1157–62. PubMed Europe PMC Scholia
12. Akt: versatile mediator of cell survival and beyond. Kim D, Chung J. J Biochem Mol Biol. 2002 Jan 31;35(1):106–15. PubMed Europe PMC Scholia
13. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Engelman JA, Luo J, Cantley LC. Nat Rev Genet. 2006 Aug;7(8):606–19. PubMed Europe PMC Scholia
14. Proto-oncogene TCL1: more than just a coactivator for Akt. Noguchi M, Ropars V, Roumestand C, Suizu F. FASEB J. 2007 Aug;21(10):2273–84. PubMed Europe PMC Scholia
15. The life of a cell: apoptosis regulation by the PI3K/PKB pathway. Duronio V. Biochem J. 2008 Nov 1;415(3):333–44. PubMed Europe PMC Scholia
16. Cell signaling by receptor tyrosine kinases. Lemmon MA, Schlessinger J. Cell. 2010 Jun 25;141(7):1117–34. PubMed Europe PMC Scholia
17. Akt, FoxO and regulation of apoptosis. Zhang X, Tang N, Hadden TJ, Rishi AK. Biochim Biophys Acta. 2011 Nov;1813(11):1978–86. PubMed Europe PMC Scholia
18. Akt signalling in health and disease. Hers I, Vincent EE, Tavaré JM. Cell Signal. 2011 Oct;23(10):1515–27. PubMed Europe PMC Scholia
19. PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control. Georgescu MM. Genes Cancer. 2010 Dec;1(12):1170–7. PubMed Europe PMC Scholia
20. The neurotrophin family of neurotrophic factors: an overview. Skaper SD. Methods Mol Biol. 2012;846:1–12. PubMed Europe PMC Scholia
21. PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E. Nucleic Acids Res. 2015 Jan;43(Database issue):D512-20. PubMed Europe PMC Scholia