GPCRs, class A rhodopsin-like (WP189)

Mus musculus

This pathway was created using the GPCRDB (Horn et al., 1998), (originally at The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references.


Nathan Salomonis , Bruce Conklin , Kristina Hanspers , Christine Chichester , Egon Willighagen , and Eric Weitz


last edited

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Mus musculus



Pathway Ontology

G protein mediated signaling pathway


Label Type Compact URI Comment
Thromboxane Metabolite chebi:26995
Dopamine Metabolite cas:62-31-7
Histamine Metabolite cas:51-45-6
Melatonin Metabolite hmdb:HMDB0001389
Serotonin Metabolite cas:50-67-9
Olfr888 GeneProduct ncbigene:258416
Olfr959 GeneProduct ncbigene:258501
Sstr2 GeneProduct ncbigene:20606
Avpr1a GeneProduct ncbigene:54140
Bdkrb2 GeneProduct ncbigene:12062
Olfr968 GeneProduct ncbigene:258605 ��Ω��Ω258603[L] ��Ω��Ω
Adrb1 GeneProduct ncbigene:11554
Gpr45 GeneProduct ncbigene:93690
Olfr970 GeneProduct ncbigene:258604
Mc2r GeneProduct ncbigene:17200
Olfr957 GeneProduct ncbigene:258740
Npy6r GeneProduct ncbigene:18169
Olfr948 GeneProduct uniprot:Q9EQ95
Avpr1b GeneProduct ncbigene:26361
Olfr876 GeneProduct ncbigene:258883
Olfr708 GeneProduct ncbigene:258173
Agtrl1 GeneProduct ncbigene:23796
Gpr83 GeneProduct ncbigene:14608
P2ry13 GeneProduct ncbigene:74191
Adora2a GeneProduct ncbigene:11540
Olfr870 GeneProduct ncbigene:57251
Htr1a GeneProduct ncbigene:15550
Drd4 GeneProduct ncbigene:13491
Olfr749 GeneProduct ncbigene:56858
Olfr933 GeneProduct ncbigene:258433
Sstr5 GeneProduct ncbigene:20609
Drd3 GeneProduct ncbigene:13490
Olfr703 GeneProduct ncbigene:258589
Olfr705 GeneProduct ncbigene:259034
Ntsr2 GeneProduct ncbigene:18217
Sstr3 GeneProduct ncbigene:20607
Fshr GeneProduct ncbigene:14309
Gpr35 GeneProduct ncbigene:64095
Ccr2 GeneProduct ncbigene:12772
Rho GeneProduct ncbigene:212541
Mc1r GeneProduct ncbigene:17199
Hrh1 GeneProduct ncbigene:15465
Olfr713 GeneProduct ncbigene:259036
Olfr70 GeneProduct ncbigene:56014
Htr4 GeneProduct ncbigene:15562
Tbxa2r GeneProduct ncbigene:21390
Galr1 GeneProduct ncbigene:14427
Olfr971 GeneProduct ncbigene:258607
Galr3 GeneProduct ncbigene:14429
Ptger4 GeneProduct ncbigene:19219
Olfr893 GeneProduct ncbigene:258333
Oprl1 GeneProduct ncbigene:18389
Brs3 GeneProduct ncbigene:12209
Cmklr1 GeneProduct ncbigene:14747
Olfr889 GeneProduct ncbigene:258475
Gpr37 GeneProduct ncbigene:14763
Opn4 GeneProduct ncbigene:30044
Olfr707 GeneProduct ncbigene:194433
Cckar GeneProduct ncbigene:12425
Agtr1b GeneProduct ncbigene:11608
Olfr71 GeneProduct ncbigene:56015
Olfr16 GeneProduct ncbigene:18313
Olfr715 GeneProduct ncbigene:258776
Cxcr3 GeneProduct ncbigene:12766
Olfr716 GeneProduct ncbigene:258597
Gpr30 GeneProduct ncbigene:76854
Olfr1355 GeneProduct ncbigene:404334
Chrm4 GeneProduct ncbigene:12672
Q9EPV1 GeneProduct uniprot:Q9EPV1
Opn3 GeneProduct ncbigene:13603
Gpr50 GeneProduct ncbigene:14765
Olfr704 GeneProduct uniprot:Q9EPF6
Sstr1 GeneProduct ncbigene:20605
Htr1b GeneProduct ncbigene:15551
Adra2a GeneProduct ncbigene:11551
Avpr2 GeneProduct ncbigene:12000
Cnr1 GeneProduct ncbigene:12801
Ccr1 GeneProduct ncbigene:12768
Hrh2 GeneProduct ncbigene:15466
Adra2b GeneProduct ncbigene:11552
Gpr27 GeneProduct ncbigene:14761
Gpr3 GeneProduct ncbigene:14748
Galr2 GeneProduct ncbigene:14428
Ntsr1 GeneProduct ncbigene:18216
Bdkrb1 GeneProduct ncbigene:12061
Ptger1 GeneProduct ncbigene:19216
Q9EQ94 GeneProduct uniprot:Q9EQ94
Adrb3 GeneProduct ncbigene:11556
Olfr144 GeneProduct ncbigene:257959
Agtr2 GeneProduct ncbigene:11609
Ednrb GeneProduct ncbigene:13618
Gpr33 GeneProduct ncbigene:14762
Cnr2 GeneProduct ncbigene:12802
Mas1 GeneProduct ncbigene:17171
Olfr155 GeneProduct ncbigene:29845
Olfr945 GeneProduct ncbigene:258499
Ptafr GeneProduct ncbigene:19204
Olfr160 GeneProduct ncbigene:80706
P2ry6 GeneProduct ncbigene:233571
Olfr148 GeneProduct ncbigene:258498
Ptgdr GeneProduct ncbigene:19214
Trhr2 GeneProduct ncbigene:170732
Fpr-rs4 GeneProduct ncbigene:14291
Agtr1 GeneProduct ncbigene:11607
Olfr944 GeneProduct ncbigene:258500 ��Ω��Ω258500[L] ��Ω��Ω
Htr5b GeneProduct ncbigene:15564
Trhr GeneProduct ncbigene:22045
Blr1 GeneProduct ncbigene:12145
Chrm1 GeneProduct ncbigene:12669
Htr5a GeneProduct ncbigene:15563
Il8rb GeneProduct ncbigene:12765
Mtnr1a GeneProduct ncbigene:17773
P2ry2 GeneProduct ncbigene:18442
Npy5r GeneProduct ncbigene:18168
Lhcgr GeneProduct ncbigene:16867
Gpr63 GeneProduct ncbigene:81006
Adora3 GeneProduct ncbigene:11542
Olfr955 GeneProduct ncbigene:258242
Htr1f GeneProduct ncbigene:15557
Olfr710 GeneProduct ncbigene:258594
F2r GeneProduct ncbigene:14062
Olfr145 GeneProduct ncbigene:258310
C3ar1 GeneProduct ncbigene:12267
Adra2c GeneProduct ncbigene:11553
Adra1d GeneProduct ncbigene:11550
Olfr961 GeneProduct ncbigene:258497
F2rl2 GeneProduct ncbigene:14064
Chrm2 GeneProduct ncbigene:243764
Sstr4 GeneProduct ncbigene:20608
Ltb4r1 GeneProduct ncbigene:16995
Olfr894 GeneProduct ncbigene:258868
Adra1a GeneProduct ncbigene:11549
Gabbr1 GeneProduct ncbigene:54393
Olfr938 GeneProduct ncbigene:258430
Olfr874 GeneProduct ncbigene:258882
Adra1b GeneProduct ncbigene:11548
Mc5r GeneProduct ncbigene:17203
Olfr926 GeneProduct ncbigene:258811
Gpr19 GeneProduct ncbigene:14760
Tcp10c GeneProduct ncbigene:21462
Olfr954 GeneProduct ncbigene:258328
Gpr34 GeneProduct ncbigene:23890
F2rl3 GeneProduct ncbigene:14065
Htr6 GeneProduct ncbigene:15565
Ccr9 GeneProduct ncbigene:12769
Ptgfr GeneProduct ncbigene:19220
Htr7 GeneProduct ncbigene:15566
Olfr934 GeneProduct ncbigene:258434
Oxt GeneProduct ncbigene:18429
Fprl1 GeneProduct ncbigene:14294
Fpr-rs1 GeneProduct ncbigene:14288
Opn1sw GeneProduct ncbigene:12057
Ccr3 GeneProduct ncbigene:12771
Gpr87 GeneProduct ncbigene:84111
P2ry1 GeneProduct ncbigene:18441
Ccr1l1 GeneProduct ncbigene:12770
Olfr242 GeneProduct ncbigene:406175 ��Ω��Ω258500[L] ��Ω��Ω
Htr2b GeneProduct ncbigene:15559
Gpr12 GeneProduct ncbigene:14738
Olfr151 GeneProduct ncbigene:406176
P2ry14 GeneProduct ncbigene:140795
Olfr15 GeneProduct ncbigene:18312
Olfr972 GeneProduct ncbigene:258603 ��Ω��Ω258603[L] ��Ω��Ω
Ptger2 GeneProduct ncbigene:19217
Ccr4 GeneProduct ncbigene:12773
Olfr701 GeneProduct ncbigene:66786
Olfr711 GeneProduct ncbigene:259037
Olfr878 GeneProduct ncbigene:258794
Olfr930 GeneProduct ncbigene:258269
Sucnr1 GeneProduct ncbigene:84112
Q9EPG0 GeneProduct uniprot:Q9EPG0_MOUSE
Olfr27 GeneProduct ncbigene:258826
Oprm1 GeneProduct ncbigene:18390
Olfr887 GeneProduct ncbigene:258415
Oxtr GeneProduct ncbigene:18430
Fpr1 GeneProduct ncbigene:14293
Oprd1 GeneProduct ncbigene:18386
Fpr-rs3 GeneProduct ncbigene:14290
Olfr49 GeneProduct ncbigene:18348
Ccr8 GeneProduct ncbigene:12776
Olfr143 GeneProduct ncbigene:258802
Cx3cr1 GeneProduct ncbigene:13051
Olfr480 GeneProduct ncbigene:56861
Ptger3 GeneProduct ncbigene:19218
Gpr65 GeneProduct ncbigene:14744
Cckbr GeneProduct ncbigene:12426
Ccrl2 GeneProduct ncbigene:54199
Rgr GeneProduct ncbigene:57811
Cysltr1 GeneProduct ncbigene:58861
Olfr159 GeneProduct ncbigene:29849
Ptgir GeneProduct ncbigene:19222
Olfr943 GeneProduct ncbigene:258323
Olfr714 GeneProduct ncbigene:259035
Oprk1 GeneProduct ncbigene:18387
Htr1d GeneProduct ncbigene:15552
Nmbr GeneProduct ncbigene:18101
Nmur1 GeneProduct ncbigene:14767
Htr2c GeneProduct ncbigene:15560
F2rl1 GeneProduct ncbigene:14063
Ppyr1 GeneProduct ncbigene:19065
Gpr37l1 GeneProduct ncbigene:171469
Olfr44 GeneProduct ncbigene:18343
Adora2b GeneProduct ncbigene:11541
Olfr19 GeneProduct ncbigene:18316
Gpr109b GeneProduct ncbigene:80885
Ccbp2 GeneProduct ncbigene:59289
P2ry12 GeneProduct ncbigene:70839
Avp GeneProduct ncbigene:11998
Opn1mw GeneProduct ncbigene:14539
Olfr146 GeneProduct ncbigene:258742
Adrb2 GeneProduct ncbigene:11555
Npy1r GeneProduct ncbigene:18166
Rrh GeneProduct ncbigene:20132
Olfr2 GeneProduct ncbigene:18317
Gpr44 GeneProduct ncbigene:14764
Olfr17 GeneProduct ncbigene:18314
Npy2r GeneProduct ncbigene:18167
Olfr6 GeneProduct ncbigene:233670
Olfr960 GeneProduct ncbigene:258276
Olfr937 GeneProduct ncbigene:258431
Mc4r GeneProduct ncbigene:17202
P2ry4 GeneProduct ncbigene:57385
Olfr157 GeneProduct ncbigene:29847
Olfr156 GeneProduct ncbigene:29846
Chrm3 GeneProduct ncbigene:12671
C5r1 GeneProduct ncbigene:12273
Fpr-rs2 GeneProduct ncbigene:14289
Htr2a GeneProduct ncbigene:15558
Cxcr4 GeneProduct ncbigene:12767
Ccr5 GeneProduct ncbigene:12774
Ccr6 GeneProduct ncbigene:12458
Grpr GeneProduct ncbigene:14829
Olfr706 GeneProduct ncbigene:258350
Tshr GeneProduct ncbigene:22095
Mc3r GeneProduct ncbigene:17201
Cmkor1 GeneProduct ncbigene:12778


  1. GPCRDB: an information system for G protein-coupled receptors. Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, et al. Nucleic Acids Res. 1998 Jan 1;26(1):275–9. PubMed Europe PMC Scholia
  2. Classifying G-protein coupled receptors with support vector machines. Karchin R, Karplus K, Haussler D. Bioinformatics. 2002 Jan;18(1):147–59. PubMed Europe PMC Scholia