Serotonin receptor 2 and ELK-SRF / GATA4 signaling (WP3242)

Bos taurus

This pathway depicts the downstream signaling of serotonin via receptors 2A, 2B, and 2C, resulting in the activation of ELK-SRF and GATA4.


Martina Summer-Kutmon , Egon Willighagen , Eric Weitz , and Alex Pico


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Bos taurus



Cell Type Ontology


Pathway Ontology

serotonin signaling pathway


Label Type Compact URI Comment
CALCIUM Metabolite cas:7440-70-2
serotonin Metabolite cas:50-67-9
1,4,5-Insp3 Metabolite cas:85166-31-0 1,4,5-Insp3
ITPR1 GeneProduct ensembl:ENSBTAG00000020455 inositol 1,4,5-triphosphate receptor 1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3708
NRAS GeneProduct ensembl:ENSBTAG00000046797 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4893
HRAS GeneProduct ensembl:ENSBTAG00000046644 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
RAF1 GeneProduct ensembl:ENSBTAG00000045748 v-raf-leukemia viral oncogene 1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
ELK1 GeneProduct ensembl:ENSBTAG00000015817 ELK1, member of ETS oncogene family
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 mitogen activated protein kinase 1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAPK1
MAPKAPK2 GeneProduct ensembl:ENSBTAG00000038107 MAP kinase-activated protein kinase 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9261
MAPK3 GeneProduct ensembl:ENSBTAG00000016156 mitogen activated protein kinase 3
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
HTR2A GeneProduct ensembl:ENSBTAG00000013498 5-hydroxytryptamine (serotonin) receptor 2A
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3356
GATA4 GeneProduct ensembl:ENSBTAG00000005425 GATA-binding protein 4/5/6
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2626
MAP2K2 GeneProduct ensembl:ENSBTAG00000024450 mitogen activated protein kinase kinase 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
RASGRF1 GeneProduct ensembl:ENSBTAG00000019940 RAS protein-specific guanine nucleotide-releasing factor 1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5923
MAP2K1 GeneProduct ensembl:ENSBTAG00000033983 mitogen activated protein kinase kinase 1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
RASGRP1 GeneProduct ensembl:ENSBTAG00000021872 RAS guanyl releasing protein 1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10125
5HTR2B GeneProduct ensembl:ENSBTAG00000039772 5-hydroxytryptamine (serotonin) receptor 2B
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3357
ELK4 GeneProduct ensembl:ENSBTAG00000004953 ETS domain-containing protein Elk-4 (SRF accessory protein 1)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2005
GNAQ GeneProduct ensembl:ENSBTAG00000009789 guanine nucleotide binding protein, alpha q polypeptide
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2776
SRF GeneProduct ensembl:ENSBTAG00000012777 serum response factor
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6722


  1. A mouse CDC25-like product enhances the formation of the active GTP complex of human ras p21 and Saccharomyces cerevisiae RAS2 proteins. Jacquet E, Vanoni M, Ferrari C, Alberghina L, Martegani E, Parmeggiani A. J Biol Chem. 1992 Dec 5;267(34):24181–3. PubMed Europe PMC Scholia
  2. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. J Biol Chem. 1995 Nov 17;270(46):27489–94. PubMed Europe PMC Scholia
  3. Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux. Cameron AM, Steiner JP, Sabatini DM, Kaplin AI, Walensky LD, Snyder SH. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1784–8. PubMed Europe PMC Scholia
  4. Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif. Engel K, Schultz H, Martin F, Kotlyarov A, Plath K, Hahn M, et al. J Biol Chem. 1995 Nov 10;270(45):27213–21. PubMed Europe PMC Scholia
  5. How MAP kinases are regulated. Cobb MH, Goldsmith EJ. J Biol Chem. 1995 Jun 23;270(25):14843–6. PubMed Europe PMC Scholia
  6. Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors. Quilliam LA, Hisaka MM, Zhong S, Lowry A, Mosteller RD, Han J, et al. J Biol Chem. 1996 May 10;271(19):11076–82. PubMed Europe PMC Scholia
  7. Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion. Nitsch RM, Deng M, Growdon JH, Wurtman RJ. J Biol Chem. 1996 Feb 23;271(8):4188–94. PubMed Europe PMC Scholia
  8. Neomycin selectively inhibits 5-hydroxytryptamine-induced contraction in the guinea pig trachea. Cox DA, Watts SW, Cohen ML. J Pharmacol Exp Ther. 1996 May;277(2):954–9. PubMed Europe PMC Scholia
  9. The brain specific Ras exchange factor CDC25 Mm: modulation of its activity through Gi-protein-mediated signals. Zippel R, Orecchia S, Sturani E, Martegani E. Oncogene. 1996 Jun 20;12(12):2697–703. PubMed Europe PMC Scholia
  10. The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site. Mott HR, Carpenter JW, Zhong S, Ghosh S, Bell RM, Campbell SL. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8312–7. PubMed Europe PMC Scholia
  11. Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits. Mattingly RR, Macara IG. Nature. 1996 Jul 18;382(6588):268–72. PubMed Europe PMC Scholia
  12. The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium. Buchsbaum R, Telliez JB, Goonesekera S, Feig LA. Mol Cell Biol. 1996 Sep;16(9):4888–96. PubMed Europe PMC Scholia
  13. Lack of efficacy of 5-HT2A receptor antagonists to reduce brain damage after 3 minutes of transient global cerebral ischaemia in gerbils. Piera MJ, Beaughard M, Michelin MT, Winslow E, Massingham R. Fundam Clin Pharmacol. 1995;9(6):562–8. PubMed Europe PMC Scholia
  14. Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, et al. EMBO J. 1995 Dec 1;14(23):5920–30. PubMed Europe PMC Scholia
  15. Stimulation of stress-activated protein kinase and p38 HOG1 kinase in murine keratinocytes following photodynamic therapy with benzoporphyrin derivative. Tao J, Sanghera JS, Pelech SL, Wong G, Levy JG. J Biol Chem. 1996 Oct 25;271(43):27107–15. PubMed Europe PMC Scholia
  16. Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils. Krump E, Sanghera JS, Pelech SL, Furuya W, Grinstein S. J Biol Chem. 1997 Jan 10;272(2):937–44. PubMed Europe PMC Scholia
  17. Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells. Imada-Shirakata Y, Kotera T, Ueda S, Okuma M. Biochem Biophys Res Commun. 1997 Jan 13;230(2):437–41. PubMed Europe PMC Scholia
  18. Convergence of MAP kinase pathways on the ternary complex factor Sap-1a. Janknecht R, Hunter T. EMBO J. 1997 Apr 1;16(7):1620–7. PubMed Europe PMC Scholia
  19. Mechanisms of serotonin-induced Ca2+ responses in mesangial cells. Goppelt-Struebe M, Stroebel M. Naunyn Schmiedebergs Arch Pharmacol. 1997 Aug;356(2):240–7. PubMed Europe PMC Scholia
  20. Fluoxetine gradually increases [125I]DOI-labelled 5-HT2A/2C receptors in the hypothalamus without changing the levels of Gq- and G11-proteins. Li Q, Muma NA, Battaglia G, Van de Kar LD. Brain Res. 1997 Nov 14;775(1–2):225–8. PubMed Europe PMC Scholia
  21. Mechanical stimulation initiates intercellular Ca2+ signaling in intact tracheal epithelium maintained under normal gravity and simulated microgravity. Felix JA, Chaban VV, Woodruff ML, Dirksen ER. Am J Respir Cell Mol Biol. 1998 May;18(5):602–10. PubMed Europe PMC Scholia
  22. The RAF family: an expanding network of post-translational controls and protein-protein interactions. Yuryev A, Wennogle LP. Cell Res. 1998 Jun;8(2):81–98. PubMed Europe PMC Scholia
  23. Prostaglandin F2alpha stimulates the Raf/MEK1/mitogen-activated protein kinase signaling cascade in bovine luteal cells. Chen DB, Westfall SD, Fong HW, Roberson MS, Davis JS. Endocrinology. 1998 Sep;139(9):3876–85. PubMed Europe PMC Scholia
  24. Sphingosine blocks human polymorphonuclear leukocyte phagocytosis through inhibition of mitogen-activated protein kinase activation. Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Kjeldsen L, Shayman JA, Boxer LA. Blood. 1999 Jan 15;93(2):686–93. PubMed Europe PMC Scholia
  25. Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase. Ravanti L, Heino J, López-Otín C, Kähäri VM. J Biol Chem. 1999 Jan 22;274(4):2446–55. PubMed Europe PMC Scholia
  26. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouysségur J. EMBO J. 1999 Feb 1;18(3):664–74. PubMed Europe PMC Scholia
  27. Protein kinase D in small cell lung cancer cells: rapid activation through protein kinase C. Paolucci L, Rozengurt E. Cancer Res. 1999 Feb 1;59(3):572–7. PubMed Europe PMC Scholia
  28. Neural encoding in orbitofrontal cortex and basolateral amygdala during olfactory discrimination learning. Schoenbaum G, Chiba AA, Gallagher M. J Neurosci. 1999 Mar 1;19(5):1876–84. PubMed Europe PMC Scholia
  29. CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway. A target of interleukin (il)-4 and il-10 anti-inflammatory action. Suttles J, Milhorn DM, Miller RW, Poe JC, Wahl LM, Stout RD. J Biol Chem. 1999 Feb 26;274(9):5835–42. PubMed Europe PMC Scholia
  30. Differential cellular expression of isoforms of inositol 1,4,5-triphosphate receptors in neurons and glia in brain. Sharp AH, Nucifora FC Jr, Blondel O, Sheppard CA, Zhang C, Snyder SH, et al. J Comp Neurol. 1999 Apr 5;406(2):207–20. PubMed Europe PMC Scholia
  31. Desensitization of P2Y2 receptor-activated transepithelial anion secretion. Clarke LL, Harline MC, Otero MA, Glover GG, Garrad RC, Krugh B, et al. Am J Physiol. 1999 Apr;276(4):C777-87. PubMed Europe PMC Scholia
  32. MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo. Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill MA, Engel K, et al. J Biol Chem. 1999 May 14;274(20):14434–43. PubMed Europe PMC Scholia
  33. Sexual functioning in depressed outpatients taking mirtazapine. Boyarsky BK, Haque W, Rouleau MR, Hirschfeld RM. Depress Anxiety. 1999;9(4):175–9. PubMed Europe PMC Scholia
  34. Effects of geldanamycin on signaling through activator-protein 1 in hypoxic HT29 human colon adenocarcinoma cells. Vasilevskaya IA, O’Dwyer PJ. Cancer Res. 1999 Aug 15;59(16):3935–40. PubMed Europe PMC Scholia
  35. TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related. Shi CS, Leonardi A, Kyriakis J, Siebenlist U, Kehrl JH. J Immunol. 1999 Sep 15;163(6):3279–85. PubMed Europe PMC Scholia
  36. Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1. Ryder JW, Fahlman R, Wallberg-Henriksson H, Alessi DR, Krook A, Zierath JR. J Biol Chem. 2000 Jan 14;275(2):1457–62. PubMed Europe PMC Scholia
  37. Insulin-like growth factor I activates c-Jun N-terminal kinase in MCF-7 breast cancer cells. Monno S, Newman MV, Cook M, Lowe WL Jr. Endocrinology. 2000 Feb;141(2):544–50. PubMed Europe PMC Scholia
  38. Brief exposure to neurotrophins produces a calcium-dependent increase in choline acetyltransferase activity in cultured rat septal neurons. Nonner D, Barrett EF, Barrett JN. J Neurochem. 2000 Mar;74(3):988–99. PubMed Europe PMC Scholia
  39. Inhibition of human prostate cancer proliferation in vitro and in a mouse model by a compound synthesized to block Ca2+ entry. Haverstick DM, Heady TN, Macdonald TL, Gray LS. Cancer Res. 2000 Feb 15;60(4):1002–8. PubMed Europe PMC Scholia
  40. Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway. Paine E, Palmantier R, Akiyama SK, Olden K, Roberts JD. J Biol Chem. 2000 Apr 14;275(15):11284–90. PubMed Europe PMC Scholia
  41. Crk activation of JNK via C3G and R-Ras. Mochizuki N, Ohba Y, Kobayashi S, Otsuka N, Graybiel AM, Tanaka S, et al. J Biol Chem. 2000 Apr 28;275(17):12667–71. PubMed Europe PMC Scholia
  42. Phosphorylation of GATA-4 is involved in alpha 1-adrenergic agonist-responsive transcription of the endothelin-1 gene in cardiac myocytes. Morimoto T, Hasegawa K, Kaburagi S, Kakita T, Wada H, Yanazume T, et al. J Biol Chem. 2000 May 5;275(18):13721–6. PubMed Europe PMC Scholia
  43. RasGRP links T-cell receptor signaling to Ras. Ebinu JO, Stang SL, Teixeira C, Bottorff DA, Hooton J, Blumberg PM, et al. Blood. 2000 May 15;95(10):3199–203. PubMed Europe PMC Scholia
  44. Inositol (1,4,5)trisphosphate metabolism and enhanced calcium mobilization in airway smooth muscle of hyperresponsive rats. Tao FC, Tolloczko B, Mitchell CA, Powell WS, Martin JG. Am J Respir Cell Mol Biol. 2000 Oct;23(4):514–20. PubMed Europe PMC Scholia
  45. Intracellular calcium mobilization induces immediate early gene pip92 via Src and mitogen-activated protein kinase in immortalized hippocampal cells. Chung KC, Sung JY, Ahn W, Rhim H, Oh TH, Lee MG, et al. J Biol Chem. 2001 Jan 19;276(3):2132–8. PubMed Europe PMC Scholia
  46. Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression. Li QJ, Vaingankar S, Sladek FM, Martins-Green M. Blood. 2000 Dec 1;96(12):3696–706. PubMed Europe PMC Scholia
  47. Evidence for protein kinase C-dependent and -independent activation of mitogen-activated protein kinase in T cells: potential role of additional diacylglycerol binding proteins. Puente LG, Stone JC, Ostergaard HL. J Immunol. 2000 Dec 15;165(12):6865–71. PubMed Europe PMC Scholia
  48. CD45 negatively regulates monocytic cell differentiation by inhibiting phorbol 12-myristate 13-acetate-dependent activation and tyrosine phosphorylation of protein kinase Cdelta. Deszo EL, Brake DK, Cengel KA, Kelley KW, Freund GG. J Biol Chem. 2001 Mar 30;276(13):10212–7. PubMed Europe PMC Scholia
  49. The information content of spontaneous retinal waves. Butts DA, Rokhsar DS. J Neurosci. 2001 Feb 1;21(3):961–73. PubMed Europe PMC Scholia
  50. Muscarinic stimulation increases basal Ca(2+) and inhibits spontaneous Ca(2+) transients in murine colonic myocytes. Bayguinov O, Hagen B, Sanders KM. Am J Physiol Cell Physiol. 2001 Mar;280(3):C689-700. PubMed Europe PMC Scholia
  51. Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling. Morgan MA, Dolp O, Reuter CW. Blood. 2001 Mar 15;97(6):1823–34. PubMed Europe PMC Scholia
  52. Oxidant stress and endothelial cell dysfunction. Lum H, Roebuck KA. Am J Physiol Cell Physiol. 2001 Apr;280(4):C719-41. PubMed Europe PMC Scholia
  53. MEK kinase activity is not necessary for Raf-1 function. Hüser M, Luckett J, Chiloeches A, Mercer K, Iwobi M, Giblett S, et al. EMBO J. 2001 Apr 17;20(8):1940–51. PubMed Europe PMC Scholia
  54. Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent. Barry OP, Mullan B, Sheehan D, Kazanietz MG, Shanahan F, Collins JK, et al. J Biol Chem. 2001 May 4;276(18):15537–46. PubMed Europe PMC Scholia
  55. The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex. Hassler M, Richmond TJ. EMBO J. 2001 Jun 15;20(12):3018–28. PubMed Europe PMC Scholia
  56. Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs. Yung Y, Yao Z, Aebersold DM, Hanoch T, Seger R. J Biol Chem. 2001 Sep 21;276(38):35280–9. PubMed Europe PMC Scholia
  57. Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation. Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Quon MJ, Reed BC, et al. J Biol Chem. 2001 Sep 21;276(38):35537–45. PubMed Europe PMC Scholia
  58. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. Chen JJ, Li Z, Pan H, Murphy DL, Tamir H, Koepsell H, et al. J Neurosci. 2001 Aug 15;21(16):6348–61. PubMed Europe PMC Scholia
  59. Guanine nucleotide exchange factors CalDAG-GEFI and CalDAG-GEFII are colocalized in striatal projection neurons. Toki S, Kawasaki H, Tashiro N, Housman DE, Graybiel AM. J Comp Neurol. 2001 Sep 3;437(4):398–407. PubMed Europe PMC Scholia
  60. Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression. Guha M, O’Connell MA, Pawlinski R, Hollis A, McGovern P, Yan SF, et al. Blood. 2001 Sep 1;98(5):1429–39. PubMed Europe PMC Scholia
  61. Mitogen-activated protein kinase is required for bryostatin 1-induced differentiation of the human acute lymphoblastic leukemia cell line Reh. Wall NR, Mohammad RM, Al-Katib AM. Cell Growth Differ. 2001 Dec;12(12):641–7. PubMed Europe PMC Scholia
  62. Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults. Suzaki Y, Yoshizumi M, Kagami S, Koyama AH, Taketani Y, Houchi H, et al. J Biol Chem. 2002 Mar 15;277(11):9614–21. PubMed Europe PMC Scholia
  63. Transient protein-protein interactions and a random-ordered kinetic mechanism for the phosphorylation of a transcription factor by extracellular-regulated protein kinase 2. Waas WF, Dalby KN. J Biol Chem. 2002 Apr 12;277(15):12532–40. PubMed Europe PMC Scholia
  64. Distinct roles of mitogen-activated protein kinase pathways in GATA-4 transcription factor-mediated regulation of B-type natriuretic peptide gene. Kerkelä R, Pikkarainen S, Majalahti-Palviainen T, Tokola H, Ruskoaho H. J Biol Chem. 2002 Apr 19;277(16):13752–60. PubMed Europe PMC Scholia
  65. The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop. Zhou B, Zhang ZY. J Biol Chem. 2002 Apr 19;277(16):13889–99. PubMed Europe PMC Scholia
  66. Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex. Mo Y, Ho W, Johnston K, Marmorstein R. J Mol Biol. 2001 Nov 30;314(3):495–506. PubMed Europe PMC Scholia
  67. Induction of neuronal differentiation by a peptide corresponding to the homophilic binding site of the second Ig module of the neural cell adhesion molecule. Soroka V, Kiryushko D, Novitskaya V, Ronn LCB, Poulsen FM, Holm A, et al. J Biol Chem. 2002 Jul 5;277(27):24676–83. PubMed Europe PMC Scholia
  68. Prolonged nuclear retention of activated extracellular signal-regulated kinase 1/2 is required for hepatocyte growth factor-induced cell motility. Tanimura S, Nomura K, Ozaki K ichi, Tsujimoto M, Kondo T, Kohno M. J Biol Chem. 2002 Aug 2;277(31):28256–64. PubMed Europe PMC Scholia
  69. Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta. Zhong XP, Hainey EA, Olenchock BA, Zhao H, Topham MK, Koretzky GA. J Biol Chem. 2002 Aug 23;277(34):31089–98. PubMed Europe PMC Scholia
  70. Differential activation of Gq/11 and Gi(3) proteins at 5-hydroxytryptamine(2C) receptors revealed by antibody capture assays: influence of receptor reserve and relationship to agonist-directed trafficking. Cussac D, Newman-Tancredi A, Duqueyroix D, Pasteau V, Millan MJ. Mol Pharmacol. 2002 Sep;62(3):578–89. PubMed Europe PMC Scholia
  71. Multiple Trp isoforms implicated in capacitative calcium entry are expressed in human pregnant myometrium and myometrial cells. Yang M, Gupta A, Shlykov SG, Corrigan R, Tsujimoto S, Sanborn BM. Biol Reprod. 2002 Sep;67(3):988–94. PubMed Europe PMC Scholia
  72. Duality of G protein-coupled mechanisms for beta-adrenergic activation of NKCC activity in skeletal muscle. Gosmanov AR, Wong JA, Thomason DB. Am J Physiol Cell Physiol. 2002 Oct;283(4):C1025-32. PubMed Europe PMC Scholia
  73. Protein kinase A-dependent cooperation between GATA and CCAAT/enhancer-binding protein transcription factors regulates steroidogenic acute regulatory protein promoter activity. Tremblay JJ, Hamel F, Viger RS. Endocrinology. 2002 Oct;143(10):3935–45. PubMed Europe PMC Scholia
  74. ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons. Hetman M, Hsuan SL, Habas A, Higgins MJ, Xia Z. J Biol Chem. 2002 Dec 20;277(51):49577–84. PubMed Europe PMC Scholia
  75. Endothelin-1-specific activation of B-type natriuretic peptide gene via p38 mitogen-activated protein kinase and nuclear ETS factors. Pikkarainen S, Tokola H, Kerkelä R, Majalahti-Palviainen T, Vuolteenaho O, Ruskoaho H. J Biol Chem. 2003 Feb 7;278(6):3969–75. PubMed Europe PMC Scholia
  76. IP3 receptor, a Ca2+ oscilator--role of IP3 receptor in development and neural plasticity. Mikoshiba K. Nihon Yakurigaku Zasshi. 2002 Nov;120(1):6P-10P. PubMed Europe PMC Scholia
  77. Extracellular signal-regulated protein kinase signaling is uncoupled from initial differentiation of central nervous system stem cells to neurons. Enarsson M, Erlandsson A, Larsson H, Forsberg-Nilsson K. Mol Cancer Res. 2002 Dec;1(2):147–54. PubMed Europe PMC Scholia
  78. Phosphorylation of hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during contextual fear conditioning: interactions between Erk-1/2 and Elk-1. Sananbenesi F, Fischer A, Schrick C, Spiess J, Radulovic J. Mol Cell Neurosci. 2002 Nov;21(3):463–76. PubMed Europe PMC Scholia
  79. Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator. Yan C, Kim D, Aizawa T, Berk BC. Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):26–36. PubMed Europe PMC Scholia
  80. Oncogenic Ha-Ras transformation modulates the transcription of the CTP:phosphocholine cytidylyltransferase alpha gene via p42/44MAPK and transcription factor Sp3. Bakovic M, Waite K, Vance DE. J Biol Chem. 2003 Apr 25;278(17):14753–61. PubMed Europe PMC Scholia
  81. Independent and cooperative activation of chromosomal c-fos promoter by STAT3. Yang E, Lerner L, Besser D, Darnell JE Jr. J Biol Chem. 2003 May 2;278(18):15794–9. PubMed Europe PMC Scholia
  82. Critical regions for activation gating of the inositol 1,4,5-trisphosphate receptor. Uchida K, Miyauchi H, Furuichi T, Michikawa T, Mikoshiba K. J Biol Chem. 2003 May 9;278(19):16551–60. PubMed Europe PMC Scholia
  83. Chronic fluoxetine differentially affects 5-hydroxytryptamine (2A) receptor signaling in frontal cortex, oxytocin- and corticotropin-releasing factor-containing neurons in rat paraventricular nucleus. Damjanoska KJ, Van de Kar LD, Kindel GH, Zhang Y, D’Souza DN, Garcia F, et al. J Pharmacol Exp Ther. 2003 Aug;306(2):563–71. PubMed Europe PMC Scholia
  84. Cardiac p300 is involved in myocyte growth with decompensated heart failure. Yanazume T, Hasegawa K, Morimoto T, Kawamura T, Wada H, Matsumori A, et al. Mol Cell Biol. 2003 May;23(10):3593–606. PubMed Europe PMC Scholia
  85. Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: involvement of a nonclassical pathway? Budnik LT, Brunswig-Spickenheier B, Mukhopadhyay AK. Mol Endocrinol. 2003 Aug;17(8):1593–606. PubMed Europe PMC Scholia
  86. Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling. Nebigil CG, Etienne N, Messaddeq N, Maroteaux L. FASEB J. 2003 Jul;17(10):1373–5. PubMed Europe PMC Scholia
  87. Exchange factors of the RasGRP family mediate Ras activation in the Golgi. Caloca MJ, Zugaza JL, Bustelo XR. J Biol Chem. 2003 Aug 29;278(35):33465–73. PubMed Europe PMC Scholia
  88. Regulation of PRAK subcellular location by p38 MAP kinases. New L, Jiang Y, Han J. Mol Biol Cell. 2003 Jun;14(6):2603–16. PubMed Europe PMC Scholia
  89. Overexpression of the serotonin 5-HT2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy. Nebigil CG, Jaffré F, Messaddeq N, Hickel P, Monassier L, Launay JM, et al. Circulation. 2003 Jul 1;107(25):3223–9. PubMed Europe PMC Scholia
  90. Mek2 is dispensable for mouse growth and development. Bélanger LF, Roy S, Tremblay M, Brott B, Steff AM, Mourad W, et al. Mol Cell Biol. 2003 Jul;23(14):4778–87. PubMed Europe PMC Scholia
  91. Calmodulin and protein kinase C regulate gap junctional coupling in lens epithelial cells. Lurtz MM, Louis CF. Am J Physiol Cell Physiol. 2003 Dec;285(6):C1475-82. PubMed Europe PMC Scholia
  92. MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils. Coxon PY, Rane MJ, Uriarte S, Powell DW, Singh S, Butt W, et al. Cell Signal. 2003 Nov;15(11):993–1001. PubMed Europe PMC Scholia
  93. RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes. Rambaratsingh RA, Stone JC, Blumberg PM, Lorenzo PS. J Biol Chem. 2003 Dec 26;278(52):52792–801. PubMed Europe PMC Scholia
  94. The sleep inducing brain lipid cis-oleamide (cOA) does not modulate serotonergic transmission in the CA1 pyramidal neurons of the hippocampus in vitro. Dougalis A, Lees G, Ganellin CR. Neuropharmacology. 2004 Jan;46(1):63–73. PubMed Europe PMC Scholia
  95. The role of GATA in mammalian reproduction. LaVoie HA. Exp Biol Med (Maywood). 2003 Dec;228(11):1282–90. PubMed Europe PMC Scholia
  96. MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding. Chrestensen CA, Schroeder MJ, Shabanowitz J, Hunt DF, Pelo JW, Worthington MT, et al. J Biol Chem. 2004 Mar 12;279(11):10176–84. PubMed Europe PMC Scholia
  97. Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes. Purcell NH, Darwis D, Bueno OF, Müller JM, Schüle R, Molkentin JD. Mol Cell Biol. 2004 Feb;24(3):1081–95. PubMed Europe PMC Scholia
  98. Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. Arozarena I, Matallanas D, Berciano MT, Sanz-Moreno V, Calvo F, Muñoz MT, et al. Mol Cell Biol. 2004 Feb;24(4):1516–30. PubMed Europe PMC Scholia
  99. RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis. Guilbault B, Kay RJ. J Biol Chem. 2004 May 7;279(19):19523–30. PubMed Europe PMC Scholia
  100. The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins. Bécamel C, Gavarini S, Chanrion B, Alonso G, Galéotti N, Dumuis A, et al. J Biol Chem. 2004 May 7;279(19):20257–66. PubMed Europe PMC Scholia
  101. Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice. García KD, Shah T, García J. Am J Physiol Cell Physiol. 2004 Oct;287(4):C1048-57. PubMed Europe PMC Scholia
  102. Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development. Bai Y, Edamatsu H, Maeda S, Saito H, Suzuki N, Satoh T, et al. Cancer Res. 2004 Dec 15;64(24):8808–10. PubMed Europe PMC Scholia
  103. Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth. Sanna B, Bueno OF, Dai YS, Wilkins BJ, Molkentin JD. Mol Cell Biol. 2005 Feb;25(3):865–78. PubMed Europe PMC Scholia
  104. Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases. Venkatasubbarao K, Choudary A, Freeman JW. Cancer Res. 2005 Apr 1;65(7):2861–71. PubMed Europe PMC Scholia
  105. MAPK-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Yu YL, Chiang YJ, Chen YC, Papetti M, Juo CG, Skoultchi AI, et al. J Biol Chem. 2005 Aug 19;280(33):29533–42. PubMed Europe PMC Scholia
  106. Cellular mechanisms of carbachol-stimulated Cl- secretion in rat epididymal epithelium. Du JY, Ruan YC, Zuo WL, Yang ZH, Chen MH, Wu ZL, et al. Biol Reprod. 2006 Sep;75(3):407–13. PubMed Europe PMC Scholia