Lacto series sphingolipid metabolism (WP5303)

Homo sapiens

lacto series glycosphingolipid biosynthesis

Authors

Conroy lipids , Alex Pico , Lars Willighagen , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology

ganglioside metabolic pathway lacto-series glycosphingolipid metabolic pathway lipid metabolic pathway

Participants

Label Type Compact URI Comment
Lewis A Metabolite lipidmaps:LMSP0504AC00
Lewis B Metabolite lipidmaps:LMSP0504AI00
Lc3Cer Metabolite lipidmaps:LMSP0504AA00
Type I H antigen Metabolite lipidmaps:LMSP0504AD00
Type IA antigen Metabolite lipidmaps:LMSP0504AF00
Sialyl-lactotetraosylceramide Metabolite lipidmaps:LMSP0601DK00
Sialyl Lewis A Metabolite lipidmaps:LMSP0601DL00
Type IB antigen Metabolite lipidmaps:LMSP0504AE00
A Lewis B Metabolite lipidmaps:LMSP0504AH00
Lc4Cer/LM1 Metabolite lipidmaps:LMSP0504AB00 ChEBI 17292, Smap 8
LacCer Metabolite lipidmaps:LMSP0501AB00
B3GALT1 GeneProduct uniprot:Q9Y5Z6
FUT3 GeneProduct uniprot:P21217
B3GALT2 GeneProduct uniprot:O43825
FUT2 GeneProduct uniprot:Q10981
FUT1 GeneProduct uniprot:P19526
B3GNT5 GeneProduct uniprot:Q9BYG0

References

  1. Handbook of Glycosyltransferases and Related Genes [Internet]. Taniguchi N, Honke K, Fukuda M, Clausen H, Furukawa K, Hart GW, et al., editors. Springer Japan; 2002. Available from: http://dx.doi.org/10.1007/978-4-431-67877-9 DOI Scholia
  2. Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells. Yamashiro S, Haraguchi M, Furukawa K, Takamiya K, Yamamoto A, Nagata Y, et al. J Biol Chem. 1995 Mar 17;270(11):6149–55. PubMed Europe PMC Scholia
  3. SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids. Merril AH Jr. Glycobiology. 2005 Jun;15(6):15G. PubMed Europe PMC Scholia