LTF danger signal response pathway (WP4478)

Homo sapiens

Lactoferrin (LTF) activates NF-kB via danger signal receptors TLR2/4 and CD14. LTF may also activate NF-kB via additional receptors RAGE and TREM1.


Laurent Winckers , Kristina Hanspers , Eric Weitz , and Egon Willighagen


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Homo sapiens



Pathway Ontology

signaling pathway


Label Type Compact URI Comment
IL1A GeneProduct ncbigene:3552
IL1B GeneProduct ncbigene:3553
IL6 GeneProduct ncbigene:3569
IL8 GeneProduct ncbigene:3576
TNF GeneProduct ncbigene:7124
IFNA GeneProduct ncbigene:3439
IFNB GeneProduct ncbigene:3456
IRAK1 GeneProduct ncbigene:3654
TRAF6 GeneProduct ncbigene:7189
TLR4 GeneProduct ncbigene:7099
LTF GeneProduct ncbigene:4057
TREM1 GeneProduct ncbigene:54210
IRAK4 GeneProduct ncbigene:51135
TLR2 GeneProduct ncbigene:7097
CD14 GeneProduct ncbigene:929
MAPK1 GeneProduct ncbigene:5594
RAGE GeneProduct ncbigene:177
NFKB1 GeneProduct ncbigene:4790
MYD88 GeneProduct ncbigene:4615


  1. Lactoferrin in a Context of Inflammation-Induced Pathology. Kruzel ML, Zimecki M, Actor JK. Front Immunol. 2017 Nov 6;8:1438. PubMed Europe PMC Scholia