Biosynthesis of gamma-aminobutyric acid (GABA) by polyamine oxidation (WP4232)
Arabidopsis thaliana
In plants, polyamines are oxidatively deaminated by copper- and flavin-containing odixases (CuAO and PAO) leading to the generation of H2O2 and 4-aminobutanal (ABAL) which can be converted to 4-aminobutyric acid (GABA). A well known neurotransmitter in animals, GABA plays a role in stress response in plants.
Authors
Alex Pico , Egon Willighagen , Denise Slenter , and Eric WeitzActivity
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Organisms
Arabidopsis thalianaCommunities
Annotations
Pathway Ontology
gamma-aminobutyric acid metabolic pathway putrescine metabolic pathway polyamine metabolic pathway classic metabolic pathway amino acid neurotransmitter metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Putrescine | Metabolite | chebi:17148 | |
| Spermine | Metabolite | chebi:15746 | |
| spermidine | Metabolite | chebi:57834 | |
| ABAL | Metabolite | chebi:17769 | |
| GABA | Metabolite | chebi:16865 | |
| GABA | Metabolite | chebi:16865 | |
| Putrescine | Metabolite | chebi:17148 | |
| ABAL | Metabolite | chebi:17769 | |
| GABA | Metabolite | chebi:16865 | |
| ALDH10A9 | GeneProduct | ncbigene:823972 | |
| PAO2 | GeneProduct | ncbigene:818904 | |
| PAO3 | GeneProduct | ncbigene:825074 | |
| PAO4 | GeneProduct | ncbigene:842894 | |
| CuAO3 | GeneProduct | ncbigene:840058 | |
| CuAO2 | GeneProduct | ncbigene:818849 | |
| ALDH10A8 | GeneProduct | ncbigene:843831 | |
| CuAO1 | GeneProduct | ncbigene:842580 |
References
- Copper-containing amine oxidases contribute to terminal polyamine oxidation in peroxisomes and apoplast of Arabidopsis thaliana. Planas-Portell J, Gallart M, Tiburcio AF, Altabella T. BMC Plant Biol. 2013 Aug 5;13:109. PubMed Europe PMC Scholia
- Polyamines under Abiotic Stress: Metabolic Crossroads and Hormonal Crosstalks in Plants. Bitrián M, Zarza X, Altabella T, Tiburcio AF, Alcázar R. Metabolites. 2012 Aug 20;2(3):516–28. PubMed Europe PMC Scholia
- Arabidopsis aldehyde dehydrogenase 10 family members confer salt tolerance through putrescine-derived 4-aminobutyrate (GABA) production. Zarei A, Trobacher CP, Shelp BJ. Sci Rep. 2016 Oct 11;6:35115. PubMed Europe PMC Scholia