Interferon type I signaling (WP585)

Homo sapiens

The type I IFNs (IFNα family, IFNβ, IFNω, IFNε and IFNκ) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other accessory proteins. The pathway above (WP585) describes the Type I Interferon signaling pathways and shows both classical IFN signaling via the JAK-STAT pathway (dark lines) and other non-canonical IFN signaling pathways. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Shamith Samarajiwa , Jildau Bouwman , Kristina Hanspers , Martijn Van Iersel , Egon Willighagen , Alex Pico , and Eric Weitz


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Homo sapiens


CPTAC PancCanNet


Pathway Ontology

immune response pathway Jak-Stat signaling pathway


Label Type Compact URI Comment
GTP Metabolite chebi:15996
GDP Metabolite chebi:17552
CRK GeneProduct ncbigene:1398
PTPN6 GeneProduct ncbigene:5777 SHP1
JAK1 GeneProduct ncbigene:3716
PIAS1 GeneProduct ncbigene:8554
FYN GeneProduct ncbigene:2534
PTPN11 GeneProduct ncbigene:5781 SHP2
Zap70 GeneProduct ncbigene:7535
PTPRC GeneProduct ncbigene:5788 CD45
PIAS3 GeneProduct ncbigene:10401
Lck GeneProduct ncbigene:3932
GAB2 Protein ncbigene:9846
CBL Protein ncbigene:867
RAPGEF1 Protein ncbigene:2889 C3G
RPS6KB1 Protein ncbigene:6198
IFNAR2b Protein ncbigene:3455
MAPKAP1 Protein ncbigene:79109
CRKL Protein ncbigene:1399
EIF4E Protein ncbigene:1977
EIF4EBP1 Protein ncbigene:1978
RPTOR Protein ncbigene:57521
PDCD4 Protein ncbigene:27250
STAT3 Protein ncbigene:6774
IRS1 Protein ncbigene:3667
SOCS1 Protein ncbigene:8651
SOCS3 Protein ncbigene:9021
IFNAR1 Protein ncbigene:3454 INTERFERON RECEPTOR
STAT1 Protein ncbigene:6772
STAT2 Protein ncbigene:6773
EIF4B Protein ncbigene:1975
PIK3CD Protein ncbigene:5293
Rac1 Protein ncbigene:5879
MAP2K3 Protein ncbigene:5606
STAT4 Protein ncbigene:6775
CrkL Protein ncbigene:1399
IRF9 Protein ncbigene:10379
RPS6KA4 Protein ncbigene:8986
STAT4 Protein ncbigene:6775
TYK2 Protein ncbigene:7297
FRAP1 Protein ncbigene:2475 AKT
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MLST8 Protein ncbigene:64223
EIF4A1 Protein ncbigene:1973
REL Protein ncbigene:5966
CREB1 Protein ncbigene:1385
STAT5 Protein ncbigene:6776
PRMT1 Protein ncbigene:3276
MAP2K6 Protein ncbigene:5608
STAT2 Protein ncbigene:6773
MTOR Protein ncbigene:2475
RAP1A Protein ncbigene:5906
IRS2 Protein ncbigene:8660
RPS6KA5 Protein ncbigene:9252
PIK3R1 Protein ncbigene:5295
VAV1 Protein ncbigene:7409
RPS6 Protein ncbigene:6194
MAP3K1 Protein ncbigene:4214
GNB2L1 Protein ncbigene:10399 RACK1
MAPK14 Protein ncbigene:1432
IFNAR2a Protein ncbigene:3455
STAT1 Protein ncbigene:6772
STAT1 Protein ncbigene:6772
IFNAR2c Protein ncbigene:3455 INTERFERON RECEPTOR
STAT3 Protein ncbigene:6774
Rac1 Protein ncbigene:5879
PIK3R2 Protein ncbigene:5296
STAT1 Protein ncbigene:6772
STAT3 Protein ncbigene:6774
STAT3 Protein ncbigene:6774
STAT1 Protein ncbigene:6772
STAT2 Protein ncbigene:6773


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  13. Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2. Owczarek CM, Hwang SY, Holland KA, Gulluyan LM, Tavaria M, Weaver B, et al. J Biol Chem. 1997 Sep 19;272(38):23865–70. PubMed Europe PMC Scholia
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  15. The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein. Ahmad S, Alsayed YM, Druker BJ, Platanias LC. J Biol Chem. 1997 Nov 28;272(48):29991–4. PubMed Europe PMC Scholia
  16. Inhibition of Stat1-mediated gene activation by PIAS1. Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, et al. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10626–31. PubMed Europe PMC Scholia
  17. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. Song MM, Shuai K. J Biol Chem. 1998 Dec 25;273(52):35056–62. PubMed Europe PMC Scholia
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  20. Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2. Farrar JD, Smith JD, Murphy TL, Murphy KM. J Biol Chem. 2000 Jan 28;275(4):2693–7. PubMed Europe PMC Scholia
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