Fatty acid biosynthesis (WP504)

Rattus norvegicus

The production of fatty acids from acetyl-CoA and NADPH through the use of enzymes known as fatty acid synthases is referred to as fatty acid synthesis. This biological process occurs within the cytoplasm of cells. The majority of acetyl-CoA that is transformed into fatty acids originates from carbohydrates through the glycolytic pathway.


Kdahlquist , Zhouyf , Thomas Kelder , Chris Evelo , Susan Coort , Christine Chichester , Martina Summer-Kutmon , Egon Willighagen , Eric Weitz , and Alex Pico


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Rattus norvegicus



Pathway Ontology

fatty acid biosynthetic pathway


Label Type Compact URI Comment
Palmitic acid Metabolite hmdb:HMDB0000220
beta-hydroxybutyryl Metabolite pubchem.compound:644065
Citric acid Metabolite hmdb:HMDB0000094
Crotonoyl-CoA Metabolite hmdb:HMDB0002009
Palmityl-CoA Metabolite hmdb:HMDB0001338
Butyryl-CoA Metabolite hmdb:HMDB0001088
Acetyl-CoA Metabolite hmdb:HMDB0001206
Malonyl-CoA Metabolite hmdb:HMDB0001175
Pyruvic acid Metabolite hmdb:HMDB0000243
Oxalacetic acid Metabolite hmdb:HMDB0000223
Acsl1 GeneProduct ncbigene:25288
Ech1 GeneProduct ncbigene:51798
Echdc2 GeneProduct ncbigene:298381
Fasn GeneProduct ncbigene:50671
Echdc3 GeneProduct ensembl:ENSRNOG00000048114
Fasn GeneProduct ncbigene:50671
Acacb GeneProduct ncbigene:116719
Acaca GeneProduct ensembl:ENSRNOG00000034013
Acsl3 GeneProduct ncbigene:114024
Echs1 GeneProduct ncbigene:140547
Scd1 GeneProduct ncbigene:246074
Acly GeneProduct ncbigene:24159
Mecr GeneProduct ncbigene:29470
Acsl4 GeneProduct ncbigene:113976
Acsl5 GeneProduct ncbigene:94340
Fasn GeneProduct ncbigene:50671
Hadhsc GeneProduct ncbigene:113965
Fasn GeneProduct ncbigene:50671
Fasn GeneProduct ncbigene:50671
Fasn GeneProduct ncbigene:50671
Fasn GeneProduct ncbigene:50671
Echdc1 GeneProduct ncbigene:361465
Acsl6 GeneProduct ncbigene:117243
Acas2 GeneProduct ncbigene:311569
Fasn GeneProduct ncbigene:50671
Pc GeneProduct ncbigene:25104
Pecr GeneProduct ncbigene:113956
Decr1 GeneProduct ncbigene:117543
Acaa2 GeneProduct ncbigene:170465