Hypoxia-dependent differentiation of myoblasts (WP5025)

Mus musculus

HIF1A modulates myogenic differentiation in hypoxia. Black arrow: activation of the signaling pathway/ protein/ molecule. Blunt red arrow: inhibition of the signaling path-way/ protein/ molecule. Round blue arrow: Interaction between two pathways.


Maximilian Saller , Laurent Winckers , Denise Slenter , Eric Weitz , Kristina Hanspers , and Egon Willighagen


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Mus musculus



Pathway Ontology

Wnt signaling pathway regulatory pathway Notch signaling pathway

Cell Type Ontology



Label Type Compact URI Comment
CDKN1A GeneProduct ncbigene:12575
MAPK14 GeneProduct ncbigene:26416
MYF5 GeneProduct ncbigene:17877
MYF6 GeneProduct ncbigene:17878
Notch pathway GeneProduct ncbigene:18128
PHD2 GeneProduct ncbigene:112405
CDNK1B GeneProduct ncbigene:12576
HIF1AN GeneProduct ncbigene:319594
HIF1A GeneProduct ncbigene:15251
MYH GeneProduct ncbigene:17879
MYOG GeneProduct ncbigene:17928
BHLHE40 GeneProduct ncbigene:20893
VEGF GeneProduct ncbigene:22339
HGF GeneProduct ncbigene:17928


  1. The resistance of fasting and nutritional aspects of Triatoma lecticularia (Stal, 1859) (Hemiptera, Reduviidae, Triatominae). Jurberg J, Costa JM. Mem Inst Oswaldo Cruz. 1989;84(3):393–9. PubMed Europe PMC Scholia
  2. MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation. Guo K, Wang J, Andrés V, Smith RC, Walsh K. Mol Cell Biol. 1995 Jul;15(7):3823–9. PubMed Europe PMC Scholia
  3. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Mahon PC, Hirota K, Semenza GL. Genes Dev. 2001 Oct 15;15(20):2675–86. PubMed Europe PMC Scholia
  4. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases. Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, et al. Biochem J. 2004 Aug 1;381(Pt 3):761–7. PubMed Europe PMC Scholia
  5. Effects of hypoxia on proliferation and differentiation of myoblasts. Li X, Zhu L, Chen X, Fan M. Med Hypotheses. 2007;69(3):629–36. PubMed Europe PMC Scholia
  6. Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Zheng X, Linke S, Dias JM, Zheng X, Gradin K, Wallis TP, et al. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3368–73. PubMed Europe PMC Scholia
  7. Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2. Kim HW, Haider HK, Jiang S, Ashraf M. J Biol Chem. 2009 Nov 27;284(48):33161–8. PubMed Europe PMC Scholia
  8. O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling. Majmundar AJ, Skuli N, Mesquita RC, Kim MN, Yodh AG, Nguyen-McCarty M, et al. Mol Cell Biol. 2012 Jan;32(1):36–49. PubMed Europe PMC Scholia
  9. Hypoxia-inducible factor 1-α induces miR-210 in normoxic differentiating myoblasts. Cicchillitti L, Di Stefano V, Isaia E, Crimaldi L, Fasanaro P, Ambrosino V, et al. J Biol Chem. 2012 Dec 28;287(53):44761–71. PubMed Europe PMC Scholia
  10. Hypoxia simultaneously alters satellite cell-mediated angiogenesis and hepatocyte growth factor expression. Flann KL, Rathbone CR, Cole LC, Liu X, Allen RE, Rhoads RP. J Cell Physiol. 2014 May;229(5):572–9. PubMed Europe PMC Scholia
  11. Hypoxia Inhibits Myogenic Differentiation through p53 Protein-dependent Induction of Bhlhe40 Protein. Wang C, Liu W, Liu Z, Chen L, Liu X, Kuang S. J Biol Chem. 2015 Dec 11;290(50):29707–16. PubMed Europe PMC Scholia
  12. Inhibitory effects of 17β-estradiol or a resveratrol dimer on hypoxia-inducible factor-1α in genioglossus myoblasts: Involvement of ERα and its downstream p38 MAPK pathways. Li Y, Liu Y, Lu Y, Zhao B. Int J Mol Med. 2017 Nov;40(5):1347–56. PubMed Europe PMC Scholia
  13. Hypoxia-inducible factor 1α (HIF-1α) is a major determinant in the enhanced function of muscle-derived progenitors from MRL/MpJ mice. Sinha KM, Tseng C, Guo P, Lu A, Pan H, Gao X, et al. FASEB J. 2019 Jul;33(7):8321–34. PubMed Europe PMC Scholia