Cardiac progenitor differentiation (WP3127)

Bos taurus

Factors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.

Authors

Martina Summer-Kutmon , Anders Riutta , Kristina Hanspers , Egon Willighagen , Eric Weitz , and Lars Willighagen

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

regulatory pathway

Cell Type Ontology

regular cardiac myocyte cardiac muscle cell

Participants

Label Type Compact URI Comment
Retinoic acid Metabolite hmdb:HMDB0001852
POU5F1 GeneProduct ensembl:ENSBTAG00000001873 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204531
NANOG GeneProduct ensembl:ENSBTAG00000020916 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111704
SOX2 GeneProduct ensembl:ENSBTAG00000011598 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181449
LIN28A GeneProduct ensembl:ENSBTAG00000048256 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131914
LIN28B GeneProduct ensembl:ENSBTAG00000043973 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187772
ZFP42 GeneProduct ensembl:ENSBTAG00000044139 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000179059
THY1 GeneProduct ensembl:ENSBTAG00000019627 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154096
SOX1 GeneProduct ensembl:ENSBTAG00000038272 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182968
PAX6 GeneProduct ensembl:ENSBTAG00000004561 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000007372
SOX17 GeneProduct ensembl:ENSBTAG00000005748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164736
FOXA2 GeneProduct ensembl:ENSBTAG00000012407 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125798
NCAM1 GeneProduct ensembl:ENSBTAG00000005710 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000149294
T GeneProduct ensembl:ENSBTAG00000018681 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164458
ANPEP GeneProduct ensembl:ENSBTAG00000016881 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166825
MIXL1 GeneProduct ensembl:ENSBTAG00000002139 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185155
ROR2 GeneProduct ensembl:ENSBTAG00000005092 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169071
WNT3A GeneProduct ensembl:ENSBTAG00000039397 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154342
BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378
INHBA GeneProduct ensembl:ENSBTAG00000002912 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122641
GSK3B GeneProduct ensembl:ENSBTAG00000048057 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000082701
FGF2 GeneProduct ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685
MESP2 GeneProduct ensembl:ENSBTAG00000027058 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000188095
KDR GeneProduct ensembl:ENSBTAG00000000782 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000128052
KIT GeneProduct ensembl:ENSBTAG00000002699 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157404
CXCR4 GeneProduct ensembl:ENSBTAG00000001060 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121966
PDGFRA GeneProduct ensembl:ENSBTAG00000007173 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134853
NOTCH1 GeneProduct ensembl:ENSBTAG00000022799 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148400
ISL1 GeneProduct ensembl:ENSBTAG00000001241 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000016082
NKX2-5 GeneProduct ensembl:ENSBTAG00000020568 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183072
GATA4 GeneProduct ensembl:ENSBTAG00000005425 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136574
TBX5 GeneProduct ensembl:ENSBTAG00000011384 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000089225
TBX20 GeneProduct ensembl:ENSBTAG00000017541 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164532
MEF2C GeneProduct ensembl:ENSBTAG00000020701 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000081189
MAPK14 GeneProduct ensembl:ENSBTAG00000020783 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112062
BMP1 GeneProduct ensembl:ENSBTAG00000000917 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168487
NOG GeneProduct ensembl:ENSBTAG00000040282 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183691
NODAL GeneProduct ensembl:ENSBTAG00000013090 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000156574
TGFB1 GeneProduct ensembl:ENSBTAG00000020457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105329
DKK1 GeneProduct ensembl:ENSBTAG00000014218 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107984
MYH7 GeneProduct ensembl:ENSBTAG00000040053 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197616
TNNT2 GeneProduct ensembl:ENSBTAG00000045789 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118194
TNNI3 GeneProduct ensembl:ENSBTAG00000006424 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000129991
MYLK3 GeneProduct ensembl:ENSBTAG00000014818 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140795
SIRPB1 GeneProduct ensembl:ENSBTAG00000039520 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198053
ACTC1 GeneProduct ensembl:ENSBTAG00000005714 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159251
MYL2 GeneProduct ensembl:ENSBTAG00000018369 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111245
SCN5A GeneProduct ensembl:ENSBTAG00000009155 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183873
IRX4 GeneProduct ensembl:ENSBTAG00000015907 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113430
IGF2 GeneProduct ensembl:ENSBTAG00000013066 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167244
IGF-I GeneProduct ensembl:ENSBTAG00000011082 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000017427
GGFBPP5 GeneProduct ensembl:ENSBTAG00000004150 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157168

References

  1. Preclinical animal models for testing iPSC/ESC-based heart therapy. Stillitano F, Karakikes I, Costa KD, Fish K, Hajjar RJ, Hulot JS. Drug Discovery Today: Disease Models [Internet]. 2012 Dec;9(4):e229–36. Available from: http://dx.doi.org/10.1016/j.ddmod.2012.04.004 DOI Scholia
  2. Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Burridge PW, Keller G, Gold JD, Wu JC. Cell Stem Cell. 2012 Jan 6;10(1):16–28. PubMed Europe PMC Scholia